2013
DOI: 10.1016/j.heares.2013.01.012
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Relations between cochlear histopathology and hearing loss in experimental cochlear implantation

Abstract: This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. Th… Show more

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Cited by 164 publications
(139 citation statements)
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“…We have observed this previously in animals receiving lower doses of medications where there was minimal impact upon hearing [O'Leary et al, 2013]. In this study, osteoneogenesis was commonly seen in association with endosteal trauma, but it is also known to occur in the cochlea after non-surgical damage such as meningitis, infection and autoimmune disease [Hoistad et al, 1998;Tinling et al, 2004;Durisin et al, 2010], so endosteal trauma appears not to be a prerequisite for its development.…”
Section: Relationships Between the Tissue Response And Hearingmentioning
confidence: 62%
“…We have observed this previously in animals receiving lower doses of medications where there was minimal impact upon hearing [O'Leary et al, 2013]. In this study, osteoneogenesis was commonly seen in association with endosteal trauma, but it is also known to occur in the cochlea after non-surgical damage such as meningitis, infection and autoimmune disease [Hoistad et al, 1998;Tinling et al, 2004;Durisin et al, 2010], so endosteal trauma appears not to be a prerequisite for its development.…”
Section: Relationships Between the Tissue Response And Hearingmentioning
confidence: 62%
“…Besides acute cochlear trauma during surgery, postoperative mechanisms seem to influence hearing preservation. Early inflammatory responses (33) or endolymphatic hydrops (34) could lead to hearing loss during the early postoperative phase, whereas tissue responses (8,35) and excitotoxicity because of electrical stimulation (36) could, among other factors, lead to delayed loss of residual hearing within months. Therefore, to further explore the correlation between trauma during surgery and postoperative hearing loss and gain more insight regarding the incidence of postoperative mechanisms, a tool to assess cochlear trauma during surgery is needed.…”
Section: Discussionmentioning
confidence: 99%
“…However, it remains unclear whether with modern electrode designs and surgical techniques, the main reason for postoperative hearing loss is acute intracochlear trauma. Other mechanisms have been proposed, and recent publications have suggested postoperative mechanisms play a relevant role (5,6).…”
mentioning
confidence: 99%