Relations Between a Novel, Reliable, and Rapid Index of Arterial Compliance (Pp-Hdi) and Well-Established Inidices of Arterial Blood Pressure (Abp) in a Sample of Hypertensive Elderly Subjects

Bergamini, L; Finelli, Maria Elisa; Bendini, Chiara; Ferrari, Ettore; Veschi, M.; Neviani, Francesca; Manni, Barbara; Pelosi, Annalisa; Rioli, Giulia; Neri, Mirco

doi:10.1016/j.archger.2009.09.007

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…The PP and large artery PWV of HHcy rats were increased significantly, while there was no significant increase in systolic blood pressure in HHcy rats. The faster PWV of the HHcy group meant the worse expansion of the artery, the more severe stiffness and the lower elasticity 29 . As a result of decreased elasticity and extension in the artery wall, the diastolic blood pressure was reduced and PP was increased in the elderly.…”

Section: Discussionmentioning

confidence: 93%

Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing

Yan

Cao

Zhen

et al. 2020

Clin Exp Pharma Physio

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Ageing and hyperhomocysteinemia (HHcy) are important risk factors for cardiovascular diseases (CVDs). HHcy affects the occurrence of vascular diseases in the elderly. So far, the mechanism of HHcy‐induced vascular ageing remains largely unknown. Autophagy level is significantly reduced in the ageing process, and restoring impaired autophagy to a normal state may be one of the possible ways to extend the expected longevity and lifespan in the future. In this study, we established the HHcy rat model by feeding a 2.5% methionine diet. Small animal ultrasound and the tail‐cuff method indicated that the vascular pulse wave velocity (PWV) and pulse pressure (PP) of HHcy rats were increased significantly compared with the control group. Vascular morphology and structure have been changed in HHcy rats, including lumen dilation, increased collagen fibre deposition and increased p53/p21/p16 expression. In vitro, under the stimulation of homocysteine (500 μmol/L, 24 hours), the rat vascular smooth muscle cells (VSMCs) presented senescence, which was characterized by the increased expression of ageing‐related markers, such as p16, p21 and p53 as well as increased senescence‐associated beta‐galactosidase (SA‐β‐gal) activity. Meanwhile, the autophagy level was decreased both in vivo and in vitro, shown as the increased level of autophagy substrate p62 and the reduced level of autophagy marker LC3 II/I in the thoracic aorta of HHcy rats and in Hcy‐treated VSMCs, respectively. The senescence phenotype of VSMCs was reversed by increased autophagy levels induced by rapamycin. Our findings indicate that decreased autophagy of VSMCs is involved in hyperhomocysteinemia‐induced vascular ageing.

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Section: Discussionmentioning

confidence: 93%

Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing

Yan

Cao

Zhen

et al. 2020

Clin Exp Pharma Physio

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“…Hypertension is a risk factor for a long‐lasting arterial wall‐remodelling leading to stiffness (Bergamini et al. 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Hypertension is a risk factor for a long-lasting arterial wall-remodelling leading to stiffness (Bergamini et al 2009). Arterial stiffness is a strong predictor of cardiovascular outcomes (Hayashi et al 2002, Weber et al 2004.…”

Section: Introductionmentioning

confidence: 99%

Pivotal factors interfering in 24‐hour blood pressure fluctuation and arterial stiffness in a community of Chinese elderly hypertensive patients

Zang

Zhang²,

Cheng³

et al. 2012

Journal of Clinical Nursing

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“…15,16 Because sleep is closely related to BP and HR, altered sleep may also contribute to MBPS. 20,21 Arterial stiffness refers to rigidity of the arterial walls resulting from loss of elastin and rise in collagen fibers in the medial layer of the arterial walls. 18,19 In addition, arterial stiffness has been strongly associated with BP changes and target organ damage, elevating cardiovascular risk in hypertensive patients.…”

mentioning

confidence: 99%

Morning Blood Pressure Surge and Nighttime Blood Pressure in Relation to Nocturnal Sleep Pattern and Arterial Stiffness

Suh

Barksdale

Logan

2014

Journal of Cardiovascular Nursing

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Relations Between a Novel, Reliable, and Rapid Index of Arterial Compliance (Pp-Hdi) and Well-Established Inidices of Arterial Blood Pressure (Abp) in a Sample of Hypertensive Elderly Subjects

Cited by 3 publications

References 23 publications

Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing

Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing

Pivotal factors interfering in 24‐hour blood pressure fluctuation and arterial stiffness in a community of Chinese elderly hypertensive patients

Morning Blood Pressure Surge and Nighttime Blood Pressure in Relation to Nocturnal Sleep Pattern and Arterial Stiffness

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