Relation of Sex and Aging to Monoamine Oxidase Activity of Human Brain, Plasma, and Platelets

Robinson, Donald S.; Davis, John M.; Nies, Alexander; Ravaris, C. Lewis; Sylwester, David

doi:10.1001/archpsyc.1971.01750120052009

Cited by 287 publications

(59 citation statements)

References 27 publications

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“…Using tyramine or tryptamine we were unable to show the increase in platelet MAO activity with age in normal subjects reported by Robinson et al (1971 ) (Robinson, Morris, Aherne & Marks, 1974).…”

contrasting

confidence: 54%

The specificity of the action of hyoscine on human learning [proceedings].

Crow¹,

Grove-White²,

Dg³

1975

Brit J Clinical Pharma

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contrasting

confidence: 54%

The specificity of the action of hyoscine on human learning [proceedings].

Crow¹,

Grove-White²,

Dg³

1975

Brit J Clinical Pharma

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“…Low MAO levels are also characteristic of alcoholics (Major & Murphy, 1978) and chronic marijuana users (Stillman et al, 1978). Since MAO is negatively correlated with sensation seeking and sensation seeking is negatively correlated with age, one might reasonably expect to find that MAO levels increase with age; one study (Robinson, Davis, Nies, Ravaris, & Sylvester, 1971) bears this out, although another (Murphy, Wright, Buchsbaum, Nichols, Costa, & Wyatt, 1976) reports no age differences in MAO levels.…”

Section: Sensation Seekingmentioning

confidence: 99%

“…Males are also different than females on some biological markers in ways that point to a higher level of sensation seeking. They have higher testosterone levels (Daitzman & Zuckerman, 1980) and lower levels of platelet MAO (Murphy et al, 1976;Robinson et al, 1971), although the findings concerning the relation between augmenting-reducing and gender are mixed (see Zuckerman, 1983).…”

Section: Sensation Seekingmentioning

confidence: 99%

Reckless behavior in adolescence: A developmental perspective

Arnett

1992

Developmental Review

758

506

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A developmental theory of reckless behavior among adolescents is presented, in which sensation seeking and adolescent egocentrism are especially prominent factors. Findings from studies of automobile driving, sex without contraception, illegal drug use, and minor criminal activity are presented in evidence of this. The influence of peers is then discussed and reinterpreted in the light of sensation seeking and adolescent egocentrism. Socialization influences are considered in interaction with sensation seeking and adolescent egocentrism, and the terms narrow and broad socialization are introduced. Factors that may be responsible for the decline of reckless behavior with age are discussed.

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“…Previous enzymatic assays performed on postmortem human brain tissue suggest that MAO-B levels increase with age (1)(2)(3)(4)(5)(6) and in neurodegenerative disease (7) although there are a few reported exceptions (8 -10). The observed 2-3-fold age-related increase in brain MAO-B levels results in increased oxidative stress that may act as a predisposing factor in the vulnerability of the brain to age-related neurodegenerative diseases such as Parkinson's disease (PD) (11)(12)(13)(14)(15)(16).…”

mentioning

confidence: 99%

Oxidative α-Ketoglutarate Dehydrogenase Inhibition via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity

Kumar

Nicholls

Andersen

2003

Journal of Biological Chemistry

114

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Age-related increases in brain monoamine oxidase B (MAO-B) and its ability to produce reactive oxygen species as a by-product of catalysis could contribute to neurodegeneration associated with Parkinson's disease. This may be via increased oxidative stress and/or mitochondrial dysfunction either on its own or through its interaction with endogenous or exogenous neurotoxic species. We have created genetically engineered dopaminergic PC12 cell lines with subtly increased levels of MAO-B mimicking those observed during normal aging. In our cells, increased MAO-B activity was found to result in increased H 2 O 2 production. This was found to correlate with a decrease in mitochondrial complex I activity which may involve both direct oxidative damage to the complex itself as well as oxidative effects on the tricarboxylic acid cycle enzyme ␣-ketoglutarate dehydrogenase (KGDH) which provides substrate for the complex. Both complex I and KGDH activities have been reported to be decreased in the Parkinsonian brain. These in vitro events are reversible by catalase addition. Importantly, MAO-B elevation was found to abolish the spare KGDH threshold capacity, which can normally be significantly inhibited before it affects maximal mitochondrial oxygen consumption rates. Our data suggest that H 2 O 2 production via subtle elevations in MAO-B levels can result in oxidative effects on KGDH that can compromise the ability of dopaminergic neurons to cope with increased energetic stress.

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Relation of Sex and Aging to Monoamine Oxidase Activity of Human Brain, Plasma, and Platelets

Cited by 287 publications

References 27 publications

The specificity of the action of hyoscine on human learning [proceedings].

The specificity of the action of hyoscine on human learning [proceedings].

Reckless behavior in adolescence: A developmental perspective

Oxidative α-Ketoglutarate Dehydrogenase Inhibition via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity

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