Relation of serum uric acid to body bulk, haemoglobin, and alcohol intake in two South Pacific Polynesian populations.

Evans, John Grimley; Prior, Ian A.; Harvey, H. P. B.

doi:10.1136/ard.27.4.319

Cited by 38 publications

(14 citation statements)

References 22 publications

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“…Our group previously reported a positive relationship between SUA and body bulk in two groups of (Evans, Prior, and Harvey, 1968). The present study confirmed this relationship in Maori and European adolescents.…”

Section: Sua and Body Bulksupporting

confidence: 91%

“…i Studies among New Zealand Maori and European adults have shown significantly higher serum uric acid levels and rates of clinical gout in the Maori (Rose and Isdale, 1963;Rose and Prior, 1963;Prior and Rose, 1966;Evans, Prior, and Morrison, 1969). This predisposition to hyperuricaemia and gout is associated with high rates of obesity, hyperglycaemia, and hypertriglyceridaemia, and represents a complex metabolic problem which contributes to morbidity and mortality in Maori adults (Prior, Rose, Harvey, and Davidson, 1966).…”

mentioning

confidence: 99%

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Uric acid, joint morbidity, and streptococcal antibodies in Maori and European teenagers. Rotorua Lakes study 3.

Stanhope¹,

Prior²

1975

Annals of the Rheumatic Diseases

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Stanhope, J. M., and Prior, I. A. M. (1975). Annals ofthe Rheumatic Diseases, 34,359-363. Uric acid, joint morbidity, and streptococcal antibodies in Maori and European teenagers. Rotorua Lakes study 3. Two hundred and ninety-four New Zealand secondary school students were examined by questionnaire, and physical and biochemical methods. The sample contained almost equal numbers of Maoris and Europeans. The findings related to joint conditions are presented. Past injury and rheumatic disease accounted for some of the reported morbidity, but no important sex or race differences in these factors emerged. There were, however, significant differences in serum uric acid levels with the Maori having higher levels than the Europeans. A significant correlation with body mass was present in both race and sex groups but a correlation with haemoglobin was present only in the European females. While hyperuricaemia was not associated with morbidity in this young sample, ethnic differences anticipated the higher prevalence of gout already observed in Maori men. i Studies among New Zealand Maori and European adults have shown significantly higher serum uric acid levels and rates of clinical gout in the Maori (Rose and Isdale, 1963; Rose and Prior, 1963; Prior and Rose, 1966;Evans, Prior, and Morrison, 1969). This predisposition to hyperuricaemia and gout is associated with high rates of obesity, hyperglycaemia, and hypertriglyceridaemia, and represents a complex metabolic problem which contributes to morbidity and mortality in Maori adults (Prior, Rose, Harvey, and Davidson, 1966).The present study was undertaken in a New Zealand secondary school, which contained almost equal numbers of Maori and Europeans aged 13 to 16 years, to find out if ethnic differences similar to those seen in adults could be shown in serum uric acid concentration, joint symptoms, smoking habits, respiratory health, and coronary risk factors including lipid levels. Serum uric acid levels are reported.In addition we present data relating to joint conditions in the sample, examining the quantity and distribution ofjoint symptoms and signs, with a view to estimating the contribution of rheumatic, hyperuricaemic, and traumatic components to joint morbidity. Rheumatic fever and rheumatic heart disease have a notably higher morbidity and mortality rate in Maori than in Europeans (Stanhope, 1975) and are presumably related to a higher rate of streptococcal infection or to the presence of some other conditioning factors. The antistreptolysin 0 and antihyaluronidase titres were estimated to detect race differences.In a previous paper we described smoking habits, respiratory health, and related variables (Stanhope and Prior, 1975a), and the differences in the pattern of coronary risk factors will also be reported (Stanhope and Prior, 1975b

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Section: Sua and Body Bulksupporting

confidence: 91%

mentioning

confidence: 99%

Uric acid, joint morbidity, and streptococcal antibodies in Maori and European teenagers. Rotorua Lakes study 3.

Stanhope¹,

Prior²

1975

Annals of the Rheumatic Diseases

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“…Recent studies have also confirmed a positive correlation between the serum urate concentration and body weight, both in Caucasians [59,67,75] and in Polynesians, recognized as a group with a tendency towards hyperuricaemia [43]. The normal range of urate production has also been defined in relation to surface area [100], implying thereby that urate production is greater in obese subjects.…”

Section: Obesitymentioning

confidence: 79%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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Abnormalities of renal handling of urate occur in a wide variety of physiological and pathological conditions and are mediated by factors including renal blood flow, glomerular filtration rate, urine flow rate, urinary constituents, metabolites, hormones and drugs. The determination of the aetiological factors in each abnormal situation is complex and the problem is discussed in relation to a variety of conditions including renal tubular disorders and metal intoxications, hypertension, toxaemia of pregnancy, glycogen storage disease, fructose administration, hereditary fructose intolerance, as well as obesity, regular alcohol consumption and hyperlipoproteinaemia. Apart from those diseases, usually genetically determined, which are associated with excessive production of urate, the most common causes of hyperuricaemia act at a renal level and result in a reduction in the net renal excretion of urate.

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“…of height to weight may be expressed by the ponderal index (Evans, Prior, and Harvey, 1968): height in inches…”

Section: Discussionmentioning

confidence: 99%

Uric acid clearance in patients with gout and normal subjects.

Snaith¹,

Scott²

1971

Annals of the Rheumatic Diseases

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Relation of serum uric acid to body bulk, haemoglobin, and alcohol intake in two South Pacific Polynesian populations.

Cited by 38 publications

References 22 publications

Uric acid, joint morbidity, and streptococcal antibodies in Maori and European teenagers. Rotorua Lakes study 3.

Uric acid, joint morbidity, and streptococcal antibodies in Maori and European teenagers. Rotorua Lakes study 3.

Abnormal Renal Urate Homeostasis in Systemic Disorders

Uric acid clearance in patients with gout and normal subjects.

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