Relation of Resting Heart Rate to Risk for All-Cause Mortality by Gender After considering Exercise Capacity (the Henry Ford Exercise Testing Project)

Aladin, Amer I.; Whelton, Seamus P.; Al-Mallah, Mouaz; Blaha, Michael J.; Keteyian, Steven J.; Juraschek, Stephen P.; Rubin, Jonathan; Brawner, Clinton A.; Michos, Erin D.

doi:10.1016/j.amjcard.2014.08.042

Cited by 63 publications

(50 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall population had a normal median body mass index (BMI: 24.0 kg/m 2 [19.2–28.3]) and mean arterial pressure (83 mm Hg [78–90]). Median heart rate (96 bpm [82–108]) was close to the upper limit of the accepted normal range . Most patients were on angiotensin‐converting enzyme inhibitors or angiotensin II receptor blocker therapy (86%) on arrival to the clinic, but only about a third of patients were receiving β‐blockers (37%).…”

Section: Resultsmentioning

confidence: 91%

“…The majority of the population was white (56% white, 33% Hispanic, 7% Asian, and 4% black). All the DMD patients had 27,28 Most patients were on angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker therapy (86%) on arrival to the clinic, but only about a third of patients were receiving b-blockers (37%). Oral steroid therapy was present in just over half of the patients (56%).…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…Five of these patients died suddenly in their sleep, 1 died of heart failure in the hospital, and 2 patients died of sepsis secondary to pneumonia (Table 4). Upon entry into the clinic, the nonsurviving cohort was older as compared with the surviving cohort (median age 24 [22][23][24][25][26][27][28][29] versus 21 [20][21][22] years, nonsurvivors versus survivors, P=0.01). Both cohorts had a similar amount of follow-up time in the clinic (28 [24-42] versus 33 months, nonsurvivors versus survivors, P=0.96).…”

Section: Nonsurvivors Versus Survivorsmentioning

confidence: 99%

See 2 more Smart Citations

Predictors of Death in Adults With Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Cheeran

Khan

Khera

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundDuchenne muscular dystrophy (DMD) is frequently complicated by development of a cardiomyopathy. Despite significant medical advances provided to DMD patients over the past 2 decades, there remains a group of DMD patients who die prematurely. The current study sought to identify a set of prognostic factors that portend a worse outcome among adult DMD patients.Methods and ResultsA retrospective cohort of 43 consecutive patients was followed in the adult UT Southwestern Neuromuscular Cardiomyopathy Clinic. Clinical data were abstracted from the electronic medical record to generate baseline characteristics. The population was stratified by survival to time of analysis and compared with characteristics associated with death. The DMD population was in the early 20s, with median follow‐up times over 2 years. All the patients had developed a cardiomyopathy, with the majority of the patients on angiotensin‐converting enzyme inhibitors (86%) and steroids (56%), but few other guideline‐directed heart failure medications. Comparison between the nonsurviving and surviving cohorts found several poor prognostic factors, including lower body mass index (17.3 [14.8–19.3] versus 25.8 [20.8–29.1] kg/m2, P<0.01), alanine aminotransferase levels (26 [18–42] versus 53 [37–81] units/L, P=0.001), maximum inspiratory pressures (13 [0–30] versus 33 [25–40] cmH2O, P=0.03), and elevated cardiac biomarkers (N‐terminal pro‐brain natriuretic peptide: 288 [72–1632] versus 35 [21–135] pg/mL, P=0.03].ConclusionsThe findings demonstrate a DMD population with a high burden of cardiomyopathy. The nonsurviving cohort was comparatively underweight, and had worse respiratory profiles and elevated cardiac biomarkers. Collectively, these factors highlight a high‐risk cardiovascular population with a worse prognosis.

show abstract

Section: Resultsmentioning

confidence: 91%

Section: Baseline Characteristicsmentioning

confidence: 99%

Section: Nonsurvivors Versus Survivorsmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of Death in Adults With Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Cheeran

Khan

Khera

et al. 2017

JAHA

View full text Add to dashboard Cite

show abstract

“…Aladin et al 32 (W) Legeai et al 30 Reunanen et al 16 (M) Nauman et al 31 1.12 (1.09-1.14) publication bias (p = 0.8). Relative to those with resting heart rate below 60 beats/min, the RR for coronary artery disease was 0.99 (95% CI 0.93-1.04) for those with resting heart rate of 60-70 beats/min, 1.08 (95% CI 1.01-1.16) for those with resting heart rate of 70-80 beats/min and 1.30 (95% CI 1.19-1.43) for those with resting heart rate above 80 beats/min (Table 1).…”

Section: (M)mentioning

confidence: 99%

“…The departure from a linear relation with resting heart rate was not significant for risk of coronary artery disease (15 studies, 13,14,16,21,23,24,26,[28][29][30][31][32]35,36,49 p for nonlinearity = 0.05, Figure 3A), stroke (10 studies, 14,16,23,24,26,28,35,36,50,51 p for nonlinearity > 0.9), noncardiovascular diseases (8 studies, 14,23,30,[42][43][44][45]49 p for nonlinearity = 0.2, Figure 3B), cancer (6 studies, 16,26,42,45,52,53 p for nonlinearity = 0.9), noncardiovascular diseases excluding cancer (3 studies, 16,18,42 p for nonlinearity = 0.4) and sudden death (3 studies, 13,21,23 p for nonlinearity = 0.6). When we used the lowest value in the included s...…”

Section: Dose-response Analysis With Restricted Cubic Spline Functionsmentioning

confidence: 99%

Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: a meta-analysis

Zhang

Wang

2016

CMAJ

View full text Add to dashboard Cite

Background:Resting heart rate is linked to risk of coronary artery disease, stroke, sudden death and noncardiovascular diseases. We conducted a meta-analysis to assess these associations in general populations and in populations of patients with hypertension or diabetes mellitus. Methods:We searched PubMed, Embase and MEDLINE from inception to Mar. 5, 2016. We used a random-effects model to combine studyspecific relative risks (RRs). We used restricted cubic splines to assess the dose-response relation. Results:We included 45 nonrandomized prospective cohort studies in the meta-analysis. The multivariable adjusted RR with an increment of 10 beats/min in resting heart rate was 1.12 (95% confidence interval [CI] 1.09-1.14) for coronary artery disease, 1.05 (95% CI 1.01-1.08) for stroke, 1.12 (95% CI 1.02-1.24) for sudden death, 1.16 (95% CI 1.12-1.21) for noncardiovascular diseases, 1.09 (95% CI 1.06-1.12) for all types of cancer and 1.25 (95% CI 1.17-1.34) for noncardiovascular diseases excluding cancer. All of these relations were linear. In an analysis by category of resting heart rate (< 60 [reference], 60-70, 70-80 and > 80 beats/min), the RRs were 0.99 (95% CI 0.93-1.04), 1.08 (95% CI 1.01-1.16) and 1.30 (95% CI 1.19-1.43), respectively, for coronary artery disease; 1.08 (95% CI 0.98-1.19), 1.11 (95% CI 0.98-1.25) and 1.08 (95% CI 0.93-1.25), respectively, for stroke; and 1.17 (95% CI 0.94-1.46), 1.31 (95% CI 1.12-1.54) and 1.57 (95% CI 1.39-1.77), respectively, for non cardiovascular diseases. After excluding studies involving patients with hypertension or diabetes, we obtained similar results for coronary artery disease, stroke and noncardiovascular diseases, but found no association with sudden death. Interpretation:Resting heart rate was an independent predictor of coronary artery disease, stroke, sudden death and noncardiovascular diseases over all of the studies combined. When the analysis included only studies concerning general populations, resting heart rate was not associated with sudden death. AbstractInfographic available at www.cmaj.ca/lookup/suppl

show abstract

Resting heart rate and incidence of venous thromboembolism

Folsom¹,

Lutsey²,

Pope³

et al. 2020

Research and Practice in Thrombosis and Haemostasis

Self Cite

View full text Add to dashboard Cite

Background/Objectives Higher resting heart rate is a risk factor for arterial cardiovascular diseases. We assessed whether higher heart rate is a risk factor for venous thromboembolism (VTE). Methods In a prospective epidemiologic cohort, the Atherosclerosis Risk in Communities (ARIC) Study, we associated resting heart rate by electrocardiogram with physician‐validated incident hospitalized VTE through 2015. We also examined whether lower heart rate variability (HRV), a marker of cardiac autonomic imbalance, might be a risk factor for VTE. Results Resting heart rate at Visit 1 (1987‐1989), when participants were 45 to 64 years old (mean, 54 years), was not associated with incidence of VTE (n = 882 cases). However, heart rate at Visit 4 (1996‐1998; mean age, 63 years) was associated positively with VTE (n = 557 cases). The adjusted hazard ratios (95% confidence intervals) of VTE across Visit 4 heart rate categories of <60, 60 to 69, 70 to 79, and ≥80 bpm were 1 (reference), 1.22 (1.01‐1.49), 1.39 (1.09‐1.78), and 1.44 (1.01‐2.06), respectively, and when evaluated continuously 1.11 (1.02‐1.21) per 10 bpm greater heart rate. For the most part, HRV indices were not associated with VTE or associations were explained by inverse correlations of HRV indices with heart rate. Conclusion We found a significant positive and independent association of resting heart rate at ARIC Visit 4 with incidence of VTE. The reason why high heart rate is a risk marker for VTE warrants further exploration.

show abstract

Relation of Resting Heart Rate to Risk for All-Cause Mortality by Gender After considering Exercise Capacity (the Henry Ford Exercise Testing Project)

Cited by 63 publications

References 32 publications

Predictors of Death in Adults With Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Predictors of Death in Adults With Duchenne Muscular Dystrophy–Associated Cardiomyopathy

Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: a meta-analysis

Resting heart rate and incidence of venous thromboembolism

Contact Info

Product

Resources

About