Resting heart rate and incidence of venous thromboembolism

Folsom, Aaron R.; Lutsey, Pamela L.; Pope, Zachary; Fashanu, Oluwaseun E.; Misialek, Jeffrey R.; Cushman, Mary; Michos, Erin D.

doi:10.1002/rth2.12288

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…However, to confirm that the associations we found were not spurious, after completing the above analysis in MESA, we then sought out to confirm whether RHR was associated with VTE in another large prospective cohort, the ARIC study, which notably had adjudicated VTE outcomes. This confirmatory work from our group was recently published and similar associations were found for RHR and incident VTE, with HRs (95% CI) of 1.44 (1.01 to 2.06) comparing RHR of ≥80 bpm to <60 bpm and 1.11 (1.02 to 1.21) per 10 bpm increment in RHR 29…”

Section: Discussionsupporting

confidence: 87%

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Resting heart rate and incident venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis

et al. 2020

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ObjectiveVenous thromboembolism (VTE) is associated with significant morbidity and mortality. Resting heart rate (RHR), which may be modifiable through lifestyle changes, has been shown to be associated with cardiovascular disease risk and with inflammatory markers that have been predictive of VTE incidence.MethodsWe examined whether RHR is also associated with VTE incidence independent of these risk factors. We studied 6479 Multi-Ethnic Study of Atherosclerosis participants free from clinical VTE at baseline who had baseline RHR ascertained by 12-lead ECG. VTE events were recorded from hospital records and death certificates using International Classification of Diseases (ICD)-9 and ICD-10 codes. We categorised RHR as <60, 60–69, 70–79 and ≥80 bpm. We used Cox hazard models to determine the association of incident VTE by RHR.ResultsParticipants had mean (SD) age of 62 (10) years and RHR of 63 (10) bpm. RHR was cross-sectionally correlated with multiple inflammatory and coagulation factors. There were 236 VTE cases after a median follow-up of 14 years. Compared with those with RHR<60 bpm, the HR (95% CI) for incident VTE for RHR≥80 bpm was 2.08 (1.31 to 3.30), after adjusting for demographics, physical activity, smoking, diabetes and use of atrioventricular (AV)-nodal blockers, aspirin and anticoagulants, and remained significant after further adjustment for inflammatory markers (2.05 (1.29 to 3.26)). Results were similar after excluding those taking AV-nodal blocker medications. There was no effect modification of these associations by sex or age.ConclusionElevated RHR was positively associated with VTE incidence after a median of 14 years; this association was independent of several traditional VTE and inflammatory markers.

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Section: Discussionsupporting

confidence: 87%

“…This may have led to some false positives or negatives. However, as noted above, our confirmatory follow-up analysis in the ARIC cohort, which did have validated VTE outcomes, found similar results 29. Second, we made use of RHR at baseline for our primary analysis, which may not be representation of RHR during follow-up.…”

Section: Discussionsupporting

confidence: 53%

Resting heart rate and incident venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis

et al. 2020

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“…Atherosclerosis is a complex systemic, progression and chronic inflammatory disease that affects mainly in large and medium-sized arteries. Several theories have emerged trying to explain the pathogenesis of atherosclerosis, including hyperlipidemia [10], lipid peroxidation [11], thrombosis [12], cell senescence [13], injury response [14], and inflammation [15]. The critical role of senescence on atherosclerosis has gained prominence.…”

Section: Causes Of Cell Senescence In Atherosclerosismentioning

confidence: 99%

The emerging role of cell senescence in atherosclerosis

Zheng

Wang

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

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Cell senescence is a fundamental mechanism of aging and appears to play vital roles in the onset and prognosis of cardiovascular disease, fibrotic pulmonary disease, liver disease and tumor. Moreover, an increasing body of evidence shows that cell senescence plays an indispensable role in the formation and development of atherosclerosis. Multiple senescent cell types are associated with atherosclerosis, senescent human vascular endothelial cells participated in atherosclerosis via regulating the level of endothelin-1 (ET-1), nitric oxide (NO), angiotensin II and monocyte chemoattractant protein-1 (MCP-1), senescent human vascular smooth muscle cells-mediated plaque instability and vascular calcification via regulating the expression level of BMP-2, OPN, Runx-2 and inflammatory molecules, and senescent macrophages impaired cholesterol efflux and promoted the development of senescent-related cardiovascular diseases. This review summarizes the characteristics of cell senescence and updates the molecular mechanisms underlying cell senescence. Moreover, we also discuss the recent advances on the molecular mechanisms that can potentially regulate the development and progression of atherosclerosis.

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“…Cumulative exposure to cannabis was not associated with resting heart rate The American Journal of Medicine, Vol 135, No 7, July 2022 heart rate was also measured with a single resting-ECG reading (10 seconds of recording time of sufficient quality). 34…”

Section: Clinical Significancementioning

confidence: 99%