Relation of Plasma Xanthine Oxidoreductase Activity to Coronary Lipid Core Plaques Assessed by Near-Infrared Spectroscopy Intravascular Ultrasound in Patients With Stable Coronary Artery Disease

Mori, Naoto; Saito, Yuichi; Saito, Kan; Matsuoka, Taka‐aki; Tateishi, Kazuya; Kadohira, Tadayuki; Kitahara, Hideki; Fujimoto, Yoshihide; Kobayashi, Yoshio

doi:10.1016/j.amjcard.2019.12.043

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…We and other groups previously reported that elevated serum uric acid level was correlated with greater coronary lipid plaques assessed by integrated backscatter-intravascular ultrasound in vivo [ 56 , 57 ], indicating that uric acid is a possible surrogate of having vulnerable plaque in patients with acute coronary syndrome. Beyond the level of serum uric acid, we also recently showed a significant relation of XOR to coronary lipid plaques evaluated by near-infrared spectroscopy in patients with chronic coronary syndrome [58] . Of note, however, no relations between XOR activity and systemic inflammation or endothelial function was found, suggesting that there might be other mechanisms in the development of coronary atherosclerosis with uric acid and XOR beyond endothelial dysfunction and inflammatory reaction [59] .…”

Section: Coronary Artery Diseasementioning

confidence: 80%

Uric acid and cardiovascular disease: A clinical review

Saito

Tanaka

Node

et al. 2021

Journal of Cardiology

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179

139

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Section: Coronary Artery Diseasementioning

confidence: 80%

Uric acid and cardiovascular disease: A clinical review

Saito

Tanaka

Node

et al. 2021

Journal of Cardiology

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179

139

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“…This study was a post-hoc analysis using patient-level pooled data of two prospective studies conducted at Chiba University Hospital [ 8 , 11 ]. A study included 68 patients with a stable CAD undergoing an elective percutaneous coronary intervention (PCI) under near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) guidance to investigate the relation between the XOR activity and coronary lipid plaque [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Although a cause-effect relationship has not been established, hyperuricemia may provoke an endothelial dysfunction via the increases in inflammation and oxidative stress, resulting in coronary atherosclerosis and clinical events [ 2 ]. Beyond the SUA levels, a recent intracoronary imaging study showed that the elevated activity of xanthine oxidoreductase (XOR), a rate-limiting enzyme in purine metabolism, was associated with coronary lipid-rich plaque in patients with a stable CAD [ 8 ]. However, the relation between the endothelial dysfunction and XOR is not fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease

et al. 2022

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Background and Objectives: Although previous studies showed that an activity of xanthine oxidoreductase (XOR), a rate-limiting enzyme in purine metabolism, beyond the serum uric acid level, was associated with the development of coronary artery disease (CAD), the underlying mechanisms are unclear. Because endothelial dysfunction and a greater blood pressure (BP) variability may play a role, we investigated the relations among the endothelial function, XOR, and BP variability. Materials and Methods: This was a post-hoc study using pooled data of patients with a stable CAD from two prospective investigations, in which the systemic endothelial function was assessed with the reactive hyperemia index (RHI) and the XOR activity was measured. The BP variability was evaluated using BP measurements during the three- and four-day hospitalization. Results: A total of 106 patients with a stable CAD undergoing a percutaneous coronary intervention were included. Of the 106 patients, 46 (43.4%) had a systemic endothelial dysfunction (RHI < 1.67). The multivariable analysis identified a higher body mass index (BMI), female gender, and diabetes as factors associated with an endothelial dysfunction. A higher BMI was also related to an elevated XOR activity, in addition to current smoking. No significant correlation was observed between the RHI and XOR activity. Similarly, the in-hospital BP variability was associated with neither the endothelial function nor XOR. Conclusions: Among patients with a stable CAD, several factors were identified as being associated with a systemic endothelial dysfunction or an elevated XOR activity. However, no direct relations between the endothelial function, XOR, and BP variability were found.

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“…After excluding 18 patients who received antihyperuricemic agents, 52 were included in the present analysis (CCS-CABG group). Another CCS cohort included 68 patients undergoing elective PCI procedures under intravascular ultrasound guidance (UMIN000027855) (CCS-PCI group) [ 11 , 12 ]. Patients with ACS ( n = 46) were also included in the present pooled data from a retrospective study (ACS group) [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Systemic endothelial function was assessed with reactive hyperemic index (RHI) using the EndoPAT 2000 device (Itamar Medical Inc., Caesarea, Israel), which is validated to evaluate endothelial function non-invasively, operator-independently, and reproducibly [ 22 ]. RHI was measured as previously described [ 6 , 8 , 9 , 10 , 11 , 12 , 19 ]. Briefly, patients fasted and refrained from taking caffeine, tobacco, and all medications for at least eight hours.…”

Section: Methodsmentioning

confidence: 99%

Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease

Hiraga

Saito

Mori

et al. 2021

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Previous studies indicated that serum uric acid (SUA) level is a marker of endothelial function in subsets of ischemic heart disease (IHD). In the present study, we aimed to evaluate the relation between the SUA level and endothelial function in patients with a broad spectrum of IHD, including obstructive coronary artery disease (CAD) and ischemia with no obstructive CAD (INOCA). Three prospective studies and one retrospective study were pooled, in which the SUA level was measured, and systemic endothelial function was assessed using the reactive hyperemia index (RHI). The primary endpoint of the present study was a correlation of the SUA level with RHI. A total of 181 patients with a broad spectrum of IHD were included, among whom, 46 (25%) had acute coronary syndrome presentation and 15 (8%) had INOCA. Overall, the SUA level was negatively correlated with the RHI (r = −0.22, p = 0.003). Multivariable analysis identified the SUA level and INOCA as significant factors associated with RHI values. In conclusion, in patients with a broad spectrum of IHD, including obstructive epicardial CAD (chronic and acute coronary syndromes) and INOCA, the SUA level was significantly and negatively correlated with systemic endothelial function assessed with the RHI. INOCA, rather than obstructive CAD, was more associated with endothelial dysfunction.

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Relation of Plasma Xanthine Oxidoreductase Activity to Coronary Lipid Core Plaques Assessed by Near-Infrared Spectroscopy Intravascular Ultrasound in Patients With Stable Coronary Artery Disease

Cited by 9 publications

References 21 publications

Uric acid and cardiovascular disease: A clinical review

Uric acid and cardiovascular disease: A clinical review

Systemic Endothelial Function, Plasma Xanthine Oxidoreductase Activity, and Blood Pressure Variability in Patients with Stable Coronary Artery Disease

Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease

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