Uric acid and cardiovascular disease: A clinical review

Saito, Yuichi; Tanaka, Atsushi; Node, Koichi; Kobayashi, Yoshio

doi:10.1016/j.jjcc.2020.12.013

Cited by 180 publications

(173 citation statements)

References 73 publications

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“…Uric acid is the end-product of purine metabolism in humans, which play crucial roles in developing cardiovascular diseases including CHD [ 47 ]. Hyperuricemia is a potential risk factor for CHD [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

et al. 2021

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Background Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of CYP7B1 polymorphisms on CHD risk. Methods In this case–control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses. Results Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95% CI = 1.07–4.49, p = 0.031), women (OR 3.17, 95% CI = 1.19–8.44, p = 0.021), and non-smokers (3.43, 95% CI = 1.16–10.09, p = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95% CI = 0.24–0.91, p = 0.025). Further analyses based on false-positive report probability validated these significant results. Besides, it was found that rs6472155 polymorphism was associated with uric acid level (p = 0.034). Conclusion Our study indicated that CYP7B1 polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.

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Section: Discussionmentioning

confidence: 99%

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

et al. 2021

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“…We and other groups have previously shown the SUA level as a marker or predictor of systemic endothelial dysfunction in patients with ACS and INOCA [ 6 , 7 , 8 ], and the present study supported the concept in the entire spectrum of IHD. While numerous epidemiological studies have reported the association of the SUA level with cardiovascular disease, including IHD [ 5 ], a therapeutic intervention targeting SUA in IHD has not been fully investigated. Noman et al previously demonstrated that in CCS patients with angiographically confirmed obstructive CAD, allopurinol (600 mg/day) significantly improved exercise capacity in a randomized, placebo-controlled, cross-over setting [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Uric acid, the end-product of purine metabolism in humans, is associated with inflammation, oxidative stress, and endothelial dysfunction, contributing to the development of atherosclerotic diseases including IHD [ 5 ]. Previous studies have indicated that urate lowering therapy had an effect on blood pressure and endothelial function [ 5 ], and we and others have reported that the serum uric acid (SUA) level was a marker or predictor of systemic endothelial dysfunction in patients with ACS and INOCA [ 6 , 7 , 8 ]. However, whether the SUA level is associated with impaired endothelial function in patients with a broad spectrum of IHD is unclear.…”

Section: Introductionmentioning

confidence: 99%

Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease

Hiraga

Saito

Mori

et al. 2021

JCM

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Previous studies indicated that serum uric acid (SUA) level is a marker of endothelial function in subsets of ischemic heart disease (IHD). In the present study, we aimed to evaluate the relation between the SUA level and endothelial function in patients with a broad spectrum of IHD, including obstructive coronary artery disease (CAD) and ischemia with no obstructive CAD (INOCA). Three prospective studies and one retrospective study were pooled, in which the SUA level was measured, and systemic endothelial function was assessed using the reactive hyperemia index (RHI). The primary endpoint of the present study was a correlation of the SUA level with RHI. A total of 181 patients with a broad spectrum of IHD were included, among whom, 46 (25%) had acute coronary syndrome presentation and 15 (8%) had INOCA. Overall, the SUA level was negatively correlated with the RHI (r = −0.22, p = 0.003). Multivariable analysis identified the SUA level and INOCA as significant factors associated with RHI values. In conclusion, in patients with a broad spectrum of IHD, including obstructive epicardial CAD (chronic and acute coronary syndromes) and INOCA, the SUA level was significantly and negatively correlated with systemic endothelial function assessed with the RHI. INOCA, rather than obstructive CAD, was more associated with endothelial dysfunction.

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“…In humans, the final oxidative product of purine catabolism is known as Serum uric acid. Various studies indicate a strong association between atherosclerotic disease and serum uric acid [7][8][9][10][11][12]. Feng et al (2018) [13] studied 564 people in China and suggested that serum uric acid levels are associated with the development and progression of atherosclerotic vascular changes.…”

Section: Introductionmentioning

confidence: 99%

A study on the relationship between serum uric acid and the thickness of intima-mediated carotid

Enhesari¹,

Khatami²,

Gozashti³

et al. 2021

J Adv Pharm Educ Res

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Uric acid and cardiovascular disease: A clinical review

Cited by 180 publications

References 73 publications

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

Impact of Serum Uric Acid Level on Systemic Endothelial Dysfunction in Patients with a Broad Spectrum of Ischemic Heart Disease

A study on the relationship between serum uric acid and the thickness of intima-mediated carotid

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