Relation of Physical Activity, Cardiac Function, Exercise Capacity, and Quality of Life in Patients With a Systemic Right Ventricle

Winter, Michiel M.; Bouma, Berto J.; Dijk, Arie P.J. van; Groenink, Maarten; Nieuwkerk, Pythia T.; Plas, Mart N. van der; Sieswerda, Gertjan T.; Konings, T.C.; Mulder, Barbara J.M.

doi:10.1016/j.amjcard.2008.06.053

Cited by 47 publications

(38 citation statements)

References 21 publications

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“…This is in agreement with Winter et al who reported that physical activity is positively associated with exercise capacity and health status in patients with a systemic right ventricle 13 .…”

Section: Study Limitationssupporting

confidence: 83%

“…Information from previous investigations of the relation between right ventricular function and exercise capacity is conflicting and more research is certainly needed 1,4,5,13,25,26 . Difficulties and differences in the evaluation of right ventricular function, as well as differences in the size and composition of the investigated groups, might be at the origin of this conflicting information.…”

Section: Study Limitationsmentioning

confidence: 99%

“…Some ventilatory limitation during exercise is present in the patient group, which might explain a low sports participation level. Other investigators previously reported low levels of physical activity in d-TGA patients and stated that this is partly caused by lower exercise intensities compared to healthy controls 12,13 .…”

Section: Univariate Predictorsmentioning

confidence: 99%

“…However, most studies do not report on physical activity, although physical activity is well known to improve the aerobic capacity in the general population 10 . Despite a few recent studies, there still is a lack of information on physical activity levels or attitudes towards exercise in this population [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

et al. 2012

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Objective Patients with Mustard/Senning repair for transposition of the great arteries (d-TGA) have an impaired exercise capacity, but information about physical activity levels is scarce. The aim of the study was to come to a better understanding of the interrelationships between determinants of exercise capacity, physical activity and self-perceived health status. Methods and resultsWe studied 39 d-TGA patients who underwent echocardiography and exercise testing, and who completed questionnaires about physical activity and perceived health status. All results were compared with normal values. Stepwise multiple regression analysis was used to assess the determinants of peak VO 2 % and exercise duration. Peak VO 2 averaged 64 ± 14.1% of the predicted normal values, which is signifi cantly lower than expected (P < 0.0001). Physical activity measures as well as perceived general health were signifi cantly lower compared to a reference population (P < 0.05). Peak heart rate and peak oxygen pulse explained together 90% of the variability in exercise duration (model F = 162.72; P < 0.0001). Type of surgery, total energy expenditure and right ventricular contractility were independent predictors of peak VO 2 % explaining 43% of the variability (model F = 8.75; P = 0.0002).Conclusions Impaired peak exercise performance in d-TGA patients results mainly from the inability to increase stroke volume and heart rate at higher exercise intensities. Senning repair and a well-preserved right ventricular function are related to a better peak VO 2 %. Furthermore, an active lifestyle has a positive eff ect on exercise capacity and perceived physical functioning. Therefore it might be indicated to encourage d-TGA patients to adopt a more physically active lifestyle.

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Section: Study Limitationssupporting

confidence: 83%

Section: Study Limitationsmentioning

confidence: 99%

Section: Univariate Predictorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

et al. 2012

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“…O que ocorre com os pacientes da síndrome é que alguns fatores, como a dispnéia e a fadiga precoce, tendem a torná-los menos ativos fisicamente, o que deteriora ainda mais o tecido muscular esquelético, criando um círculo vicioso. 71 Redução do fluxo sanguíneo A redução do fluxo sanguíneo para a musculatura esquelética poderia contribuir para os prejuízos observados nesse tecido devido a uma menor eficiên-cia no transporte de oxigênio, nutrientes, hormônios e metabólitos. Apesar de alguns trabalhos na literatura mostrarem essa redução, 49,72,73 outros estudos não verificaram essa diminuição, [74][75][76][77][78] de modo que fatores ainda não conhecidos podem ser determinantes na redução ou manutenção do fluxo sanguíneo.…”

Section: Redução Na Ingestão Alimentarunclassified

Relevância e tratamento das lesões características da insuficiência cardíaca na musculatura esquelética

Júnior

2009

Medicina (Ribeirão Preto)

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Pacientes com insuficiência cardíaca, a via final das doenças cardiovasculares e a primeira causa de internação em idosos no Brasil, apresentam deterioração do tecido muscular esquelético. Além disso, as lesões na musculatura têm relação direta com a qualidade de vida e a autonomia dos pacientes, por meio do nível de tolerância aos esforços físicos, além de constituírem um preditor independente de mortalidade na síndrome. Ao longo da presente revisão de literatura serão discutidos em relação à insuficiência cardíaca: seu conceito e um breve histórico; a importância da musculatura esquelética; as anormalidades funcionais, estruturais, bioquímicos e moleculares que acometem esse tecido; as potenciais causas dessas alterações (hiperatividade simpática, redução na ingestão alimentar, espécies reativas de oxigênio, citocinas pró-inflamatórias e diminuição do nível de atividade física e do fluxo sanguíneo); e os efeitos da principal terapia direcionada para combater essa disfunção, o treinamento físico aeróbio de intensidade moderada. Reconhecida a importância do tecido muscular esquelético na síndrome, essa é uma área da investigação científica com muitos temas ainda não estudados, como o efeito de terapias farmacológicas utilizadas pelos pacientes, de exercícios físicos aeróbios de maior intensidade e intervalados, de exercícios físicos de força, de intervenções nutricionais e de terapias celulares e gênicas. No futuro, os resultados desses estudos que serão desenvolvidos certamente contribuirão para uma menor degeneração da musculatura esquelética na doença, o que, consequentemente, vai melhorar a ualidade de vida, a autonomia e o prognóstico dos pacientes.

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Cardiac and Exercise Physiology in Adolescence

Müller

Hager

2016

Congenital Heart Disease and Adolescence

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Relation of Physical Activity, Cardiac Function, Exercise Capacity, and Quality of Life in Patients With a Systemic Right Ventricle

Cited by 47 publications

References 21 publications

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

Relevância e tratamento das lesões características da insuficiência cardíaca na musculatura esquelética

Cardiac and Exercise Physiology in Adolescence

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