Relation of Osteoprotegerin , Visfatin and Ghrelin to Metabolic Syndrome in Type 2 Diabetic Patients

Ahmed, Manal Basyouni; Ismail, Maha Imam Ahmed; Meki, Abdel-Raheim M.A.

doi:10.12816/0024107

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…Visfatin is a ubiquitous adipokine that is produced in adipose tissue, bone marrow, skeletal muscle, and liver with a physiological role not completely understood [ 14 – 16 ]. In the context of metabolic diseases, most studies have focused on increased circulating levels and adipose tissue expression of visfatin [ 17 , 18 ]. Also, it was initially proposed as a clinical marker of atherosclerosis, endothelial dysfunction and vascular damage [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Auguet

Aragonès

Guiu‐Jurado

et al. 2016

BMC Cardiovasc Disord

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BackgroundNovel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery.MethodsWe evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16).ResultsWe found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects.ConclusionsOf all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

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Section: Discussionmentioning

confidence: 99%

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Auguet

Aragonès

Guiu‐Jurado

et al. 2016

BMC Cardiovasc Disord

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“…McLaughlin et al have concluded that ghrelin correlates with MetS mainly based on obesity as well as they identified lower ghrelin levels in patients with MetS and obesity than in non-obese MetS patients [10]. Likewise, many studies confirm the relation between MetS and ghrelin [11][12][13][14][15][16].…”

Section: Ghrelin and Metabolic Syndromementioning

confidence: 99%

“…Ghrelin is inversely correlated with MetS components, and studies confirmed its role in MetS prediction. Also, a positive correlation of ghrelin levels with hypertension, insulin resistance, and obesity has been found [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers in Metabolic Syndrome

Zlibut¹,

Agoşton-Coldea²,

Mocan³

et al. 2019

Ultimate Guide to Insulin

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Nowadays, biomarkers are useful in the early detection and risk stratification of metabolic syndrome (MetS) patients. Studies confirmed the implication of adipokines, neuropeptides, inflammatory cytokines, prothrombotic factors, and others in MetS pathogenesis. Leptin:adiponectin ratio is useful in predicting insulin resistance and MetS severity; leptin is correlated with obesity and waist size and adiponectin is inversely related with MetS components. Ghrelin is inversely correlated with MetS components, and studies confirmed its role in MetS prediction. Regarding the pro-inflammatory cytokines, studies confirmed that interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha are positively correlated with hypertriglyceridemia, hypertension, fasting glucose levels, insulin resistance, and in postmenopausal women with central obesity. Oxidized low-density lipoprotein (LDL) levels could be implicated in insulin resistance. Recent studies also confirmed that novel biomarkers such as pentraxin-3 are positively correlated with MetS severity and the presence of vascular lesions, and it could bring new data on the MetS mechanism. Within this chapter, we review data on the contribution of biomarkers as well as on the stratification of MetS patients, discussing their key contribution for creating a risk assessment algorithm.

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“…Visfatin levels were found to be higher in type 2 diabetic patients (17,18) and also in patients with metabolic syndrome, especially in those with carotid plaques and in patients with polycystic ovary syndrome (19)(20)(21). The Visfatin was strongly correlated with proinflammatory gene expression, including CD68 and the tumor necrosis factor-alpha gene; it was also found to have a proinflammatory effect (22).…”

Section: Discussionmentioning

confidence: 97%

Visfatin levels in hormonally inactive adrenal adenoma and their association with metabolic parameters

Atasoy¹,

Çakır²,

Ahbab³

et al. 2018

Turk J Med Sci

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Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma. Materials and methods: Thirty patients recently diagnosed with adrenal adenoma along with 30 healthy participants were studied in a tertiary healthcare center. Twenty-four-hour ambulatory blood pressure monitoring and carotid artery intima-media thickness (CIMT) measurements were performed. Results: The frequencies of diabetes mellitus and hypertension were found to be statistically higher in the adrenal adenoma group. Although the values of mean fasting glucose, insulin, HOMA-IR levels, and the mean, maximum, minimum, delta systolic, and diastolic blood pressures were established to be higher in the adrenal adenoma group, the differences were not found to be statistically significant. Mean high-sensitive C-reactive protein, visfatin levels, and CIMT were seen to be significantly higher in the adenoma group. Conclusion: Cardiometabolic risk factors as well as the visfatin levels were established to be higher in patients with adrenal adenoma. Elevated visfatin levels might play a role in the development and metabolic process of adrenal adenoma.

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Relation of Osteoprotegerin , Visfatin and Ghrelin to Metabolic Syndrome in Type 2 Diabetic Patients

Abstract: Background: It is now realized that insulin resistance plays a principal role in initiating the pathologic manifestations of the metabolic syndrome (MetS).

Cited by 13 publications

References 38 publications

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Biomarkers in Metabolic Syndrome

Visfatin levels in hormonally inactive adrenal adenoma and their association with metabolic parameters

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