Relation of Obesity to Acute Myocardial Infarction in Japanese Patients  Differences in Gender and Age

Shiraishi, Jun; Kohno, Yoshio; Sawada, Takahisa; Nishizawa, Shinya; Arihara, Masayasu; Hadase, Mitsuyoshi; Hyogo, Masayuki; Yagi, Takakazu; Shima, Takatomo; Nakazawa, Atsuko; Shigeta, Masako; Yamada, Hiroyuki; Tatsumi, Tomohide; Azuma, Akihiro; Matsubara, Hiroaki

doi:10.1253/circj.70.1525

Cited by 34 publications

(24 citation statements)

References 31 publications

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“…Previous studies reported that obesity and low HDL cholesterolemia were independent risk factors among younger male patients [33][34][35] , which is consistent with our findings. In particular, male patients with AMI aged 40 years showed significant increases in BMI and the prevalence of obesity (Fig.…”

Section: Changes In the Prevalence Of Coronary Risk Factors In Ami Pasupporting

confidence: 93%

Trends in Coronary Risk Factors Among Patients with Acute Myocardial Infarction Over the Last Decade: The Yamagata AMI Registry

Nishiyama

Watanabe

Arimoto

et al. 2010

JAT

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Aim:Recently, there has been an increase in the prevalence of coronary risk factors, such as diabetes and dyslipidemia, in Japan; however, it is unclear whether this has resulted in an increased incidence of acute myocardial infarction (AMI). We investigated the relationship between risk factors changes and AMI incidence in a Japanese population. Methods: Trends in AMI incidence (per 100,000 person-years) were examined using data from the Yamagata AMI Registry from 1993 to 2007. We included 6,222 patients with a first-ever AMI ( Results: The age-adjusted incidence of AMI increased significantly in men, but not in women. Younger men particularly showed a significant increase in the incidence of AMI. The prevalence of hypertension and diabetes increased in both genders; however, the prevalence of treatment for risk factors was significantly lower in men than women. Younger men showed significant increases in obesity and hypertriglyceridemia. Consequently, risk factors associated with the metabolic syndrome had accumulated among younger men. We revealed that hypertension, diabetes, hypercholesterolemia and current smoking were independent risk factors for AMI. Conclusions: The incidence rate for AMI increased significantly in men, especially younger men. Preventive care for risk factors associated with metabolic syndrome, in addition to conventional risk factors, may be required in younger men. J Atheroscler Thromb, 2010; 17:989-998.

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Section: Changes In the Prevalence Of Coronary Risk Factors In Ami Pasupporting

confidence: 93%

Trends in Coronary Risk Factors Among Patients with Acute Myocardial Infarction Over the Last Decade: The Yamagata AMI Registry

Nishiyama

Watanabe

Arimoto

et al. 2010

JAT

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“…These findings agree with other studies of Chinese and other Asian populations, documenting linear relations of BMI or waist circumference with cardiovascular disease risk factors. 5,6,10,[13][14][15][16] Moreover, based on the sensitivity, specificity and ROC calculations, our data suggest a BMI of 24 kg/m 2 for both men and women, and a waist circumference of 85 cm for men and 80 cm for women as appropriate cut-off values for the designation of overweight and central adiposity in this population.…”

Section: Discussionmentioning

confidence: 60%

Relationships Between Indices of Obesity and Its Cardiovascular Comorbidities in a Chinese Population

Lü

Jia

et al. 2008

Circ J

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he prevalence of obesity and overweight has increased dramatically in both economically developed countries and developing countries. 1 It is estimated that more than 1 billion adults worldwide are overweight (ie, body mass index (BMI) of 25.0-29.9 kg/m 2 ) and more than 300 million adults worldwide are obese (BMI ≥30.0 kg/m 2 ). 2 Body composition and body fat distribution are 2 important determinants for the risk of cardiovascular disease. Observational epidemiological studies have documented that obesity is associated with cardiovascular risk factors such as diabetes mellitus, hypertension and dyslipidemia. [3][4][5] The current definitions of overweight/obesity and central adiposity recommended by the World Health Organization (WHO) are based on data from Western populations. 2 However, some recent data suggest that these definitions may not be appropriate for the Chinese population, which have a higher percentage of body fat than Whites at any given BMI. 6 In China, the prevalence of overweight is much lower than Circulation Journal Vol.72, June 2008 the Western population; 7 however, obesity comorbidities in the Chinese population have rates much closer to those of Western populations. For example, the prevalence of diabetes has increased to 5.2% in Chinese adults, which is comparable to the rate of 7.8% in Americans. 8 In addition, Chinese adults have a stronger association between BMI and obesity-related disease conditions compared with the US population; 9 a moderate increase in BMI makes a Chinese adult more prone to hypertension, dylispidemia and hyperuricemia. 10 In response to these findings, overweight in the Chinese population is suggested to be defined as a BMI ≥24 kg/m 2 , and waist circumference cut-off values are suggested to be 80 cm for both men and women. 6 However, these recommendations are provisional and require further validation with more epidemiologic study. 11 In the current analysis, our aim was to identify the cut-off values for BMI and waist circumference that are associated with increased risk of cardiovascular disease in a Chinese population in Shanghai, China. Methods Study ParticipantsThe study participants were those who had participated in the Shanghai Type 2 Diabetes Survey. 12 Briefly, the Survey used a stratified sampling method to select a representative sample of the general population aged >15 years in Shanghai, China. A total of 14,351 individuals were randomly selected from 12 primary sampling units (street districts in urban areas or townships in rural areas) and invited to participate. We excluded 534 subjects aged between 15 and 18 years because the standard definitions of cardiovascular comor- Background Current definitions of overweight/obesity and central adiposity guidelines are based on Western populations, and may not be appropriate for the Chinese population. More data among Chinese are needed to address this issue. We aimed to identify cut-offs for body mass index (BMI) and waist circumference that confer increased risk of cardiovascular disease in a Ch...

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“…Hayashi et al recommended an age-specific assessment of VFA when evaluating obesity-related cardiovascular risk factors in females 32) . Other studies have also confirmed increases in cardiovascular events and thr frequency of metabolic risk factors after menopause 33,34) . Taken together, it is possible that the female subjects in the present study were too young to assess the effect of visceral fat on the number of metabolic risk factors.…”

Section: Discussionmentioning

confidence: 76%

Absolute Value of Bioelectrical Impedance Analysis-Measured Visceral Fat Area with Obesity-Related Cardiovascular Risk Factors in Japanese Workers

Okauchi

Kishida

Funahashi

et al. 2010

JAT

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Aim:The accumulation of Visceral fat is known to precede metabolic disorders and atherosclerosis. This study aimed to determine the relationships between body mass index (BMI), waist circumference (WC), estimated visceral fat area (eVFA) measured by bioelectrical impedance analysis (BIA), and obesity-related cardiovascular risk factors. Methods: The study population was 2,870 middle-aged Japanese employees (males/females 2,322/ 548), who had undergone a health check-up. Results: In the receiver operating characteristic (ROC) curve, the cutoff levels yielding maximal sensitivity plus specificity for predicting the prevalence of ≥ 2 risks were, 24.5 kg/m 2 for BMI, 84.6 cm for WC, and 111 cm 2 for eVFA in males, and 23.6 kg/m 2 , 81.5 cm, and 67 cm 2 in females. The average number of risk factors was over 1.0 in those with a BMI ≥ 25 kg/m 2 and with a WC ≥ 85 cm for males, ≥ 28 kg/m 2 and ≥ 95 cm respectively for females, and those with an eVFA ≥ 100 cm 2 for both males and females. In males, it was around 1.0 with cutoff levels of BMI, WC, and eVFA from the ROC curve. However, in females, it was around 0.6, because the prevalence of subjects with obesity and multiple risks was very low. Conclusions: These results suggested that the cutoff level for visceral fat reduction should be set based on an absolute value of risk factors, rather than a calculated value. In regular health check-up, it may be useful to set an absolute cutoff value for eVFA at 100 cm 2 as criteria to screen for multiple obesity-related cardiovascular risk factors.

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Relation of Obesity to Acute Myocardial Infarction in Japanese Patients Differences in Gender and Age

Cited by 34 publications

References 31 publications

Trends in Coronary Risk Factors Among Patients with Acute Myocardial Infarction Over the Last Decade: The Yamagata AMI Registry

Trends in Coronary Risk Factors Among Patients with Acute Myocardial Infarction Over the Last Decade: The Yamagata AMI Registry

Relationships Between Indices of Obesity and Its Cardiovascular Comorbidities in a Chinese Population

Absolute Value of Bioelectrical Impedance Analysis-Measured Visceral Fat Area with Obesity-Related Cardiovascular Risk Factors in Japanese Workers

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