Relation of nocturnal blood pressure dipping to cellular adhesion, inflammation and hemostasis

Känel, Roland von; Jain, Shamini; Mills, Paul J.; Nelesen, Richard A.; Adler, Karen A.; Hong, Suzi; Perez, Christy J.; Dimsdale, Joel E.

doi:10.1097/00004872-200411000-00009

Cited by 68 publications

(36 citation statements)

References 51 publications

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“…Besides, non-dipping blood pressure profile at night and emotional and mood factors are associated with elevated D-dimer [37,38], and the impact of these aspects has not been systematically evaluated in the majority of the studies.…”

Section: Discussionmentioning

confidence: 99%

High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea

et al. 2015

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Obstructive sleep apnoea is a risk factor for pulmonary embolism. Elevated D-dimer levels and other biomarkers are associated with recurrent pulmonary embolism. The objectives were to compare the frequency of elevated D-dimer levels (>500 ng·mL ) and further coagulation biomarkers after oral anticoagulation withdrawal in pulmonary embolism patients, with and without obstructive sleep apnoea, including two control groups without pulmonary embolism.We performed home respiratory polygraphy. We also measured basic biochemical profile and haemogram, and coagulation biomarkers (D-dimer, prothrombin fragment 1+2, thrombin-antithrombin complex, plasminogen activator inhibitor 1, and soluble P-selectin).64 (74.4%) of the pulmonary embolism cases and 41 (46.11%) of the controls without pulmonary embolism had obstructive sleep apnoea. Plasmatic D-dimer was higher in PE patients with OSA than in those without obstructive sleep apnoea. D-dimer levels were significantly correlated with apnoeahypopnoea index, and nocturnal hypoxia. There were more patients with high D-dimer after stopping anticoagulants in those with pulmonary embolism and obstructive sleep apnoea compared with PE without obstructive sleep apnoea (35.4% versus 19.0%, p=0.003). Apnoea-hypopnoea index was independently associated with high D-dimer.Pulmonary embolism patients with obstructive sleep apnoea had higher rates of elevated D-dimer levels after anticoagulation discontinuation for pulmonary embolism than in patients without obstructive sleep apnoea and, therefore, higher procoagulant state that might increase the risk of pulmonary embolism recurrence. @ERSpublications Pulmonary embolism patients with sleep apnoea are more likely to have elevated postanticoagulation plasma D-dimer

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Section: Discussionmentioning

confidence: 99%

High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea

et al. 2015

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“…Reactive oxygen species formation was signifi cantly increased in extreme dippers [47]. In non-dippers however interruption in hemostastic condition has also been noticed [48], with the increase in D-dimer, plasminogen activator inhibitor-1 and intercellular adhesion molecule-1 concentrations.…”

Section: Mechanism Driving Bpvmentioning

confidence: 84%

Blood pressure variability: Epidemiological and clinical issues

Krzych¹,

Bochenek²

2013

Cardiol J.

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“…19 The presence of more prominent endothelial perturbation in individuals with non-dipping nocturnal BP is also reflected by increased levels of von Willebrand factor, a marker of endothelial damage. 20 Quinaglia et al…”

Section: Endothelial Dysfunction and Bp Controlmentioning

confidence: 99%

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

Shantsila

2011

J Hum Hypertens

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Relation of nocturnal blood pressure dipping to cellular adhesion, inflammation and hemostasis

Abstract: Nocturnal BP non-dipping is associated with elevated levels of molecules related to endothelial dysfunction and atherosclerosis. The finding provides one possible mechanism linking non-dipping with cardiovascular disease.

Cited by 68 publications

References 51 publications

High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea

High D-dimer levels after stopping anticoagulants in pulmonary embolism with sleep apnoea

Blood pressure variability: Epidemiological and clinical issues

Endothelial dysfunction and diurnal variation of blood pressure: night secrets of arterial hypertension?

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