Relation of Lesion Location to Verbal and Nonverbal Mood Measures in Stroke Patients

Gainotti, Guido; Azzoni, Antonella; Gasparini, Francesca; Marra, Camillo; Razzano, Carmelina

doi:10.1161/01.str.28.11.2145

Cited by 74 publications

(56 citation statements)

References 17 publications

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“…7 45 Gainotti et al 26 used the DSM-III-R diagnostic criteria with the Visual Analogue Dysphoria Scale to elicit responses from patients suffering from aphasia. The inclusion of a measure to assess depression in patients with aphasia is unfortunately overlooked by many studies.…”

Section: Assessment Of Depressionmentioning

confidence: 99%

“…Primeau 15 noted that because the DSM-III criteria rely heavily on verbal responses, assessment of these patients with the DSM-III criteria may not be feasible, and interpretation of their responses may be incorrect. Gainotti et al 26 noted that when assessment of patients with aphasia took their communication deficit into account, left hemisphere lesions were not a major determinant of PSD.…”

Section: Assessment Of Depressionmentioning

confidence: 99%

“…15,26 For this reason, several studies opted to move away from DSM criteria and based diagnosis of depression on other criteria. Two studies used the Centre for Epidemiological Studies-Depression, 41 A concern with the use of the DSM criteria is that the diagnostic criteria included vegetative symptoms of depression, such as psychomotor retardation, fatigue, and sleep and appetite disturbances, which may be a consequence of the stroke event itself independent of affect.…”

Section: Assessment Of Depressionmentioning

confidence: 99%

“…34,42 One study was noted to have staggered assessment times between the acute and chronic stages of stroke. 26 The time of assessment since stroke onset can potentially influence study outcome. Patients interviewed during the subacute phase may still be adjusting to their stroke experience, and depression in these patients may reflect this transition stage.…”

Section: Timing Of First Interview After Strokementioning

confidence: 99%

“…1,22,30,31,36,41,45,48 Three studies 33,36,40 used a casecontrol design in which patients were sampled according to depressive symptoms. Gainotti et al 26 and Sato et al 47 used a cross-sectional design.…”

Section: Research Design: Cohort Versus Case-control Studymentioning

confidence: 99%

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Lesion location and poststroke depression

Morris

Robinson²,

Raphael³

et al. 1996

JNP

140

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Background-It has been hypothesized that poststroke depression (PSD) results from left hemisphere lesions. However, attempts to systematically review the data investigating lesion location and PSD have yielded conflicting results. We sought to investigate the methodological differences across the literature studying the relationship between lesion location and PSD. Summary of Review-A MEDLINE literature search to retrieve articles investigating the association between PSD and lesion location was performed. Information sought included source population of samples, definition of depression, standardized measurement of stroke and depression, blinding, time since stroke onset, and study design. Odds ratios (ORs) and 95% CIs were calculated with the use of Review Manager and MetaView statistical software. Twenty-six original articles were reviewed. Much of the heterogeneity across studies reflected differences in methodology. The direction of association between left hemisphere lesion location and PSD varied depending on whether patients were sampled as inpatients (OR, 1.36; 95% CI, 1.05 to 1.76) or from the community (OR, 0.60; 95% CI, 0.39 to 0.92). Change in the direction of association was also observed across assessment interval from the acute stroke (OR, 2.14; 95% CI, 1.50 to 3.04) to the chronic stroke (OR, 0.53; 95% CI, 0.30 to 0.93) phase. Differences in the measurement of depression, study design, and presentations of results also may have contributed to the heterogeneity of the findings. Conclusions-Several key initiatives should be addressed before future research is undertaken, including the development of a comprehensive measure of PSD, optimal poststroke assessment intervals, and determination of a representative population reference.

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Section: Assessment Of Depressionmentioning

confidence: 99%

Section: Assessment Of Depressionmentioning

confidence: 99%

Section: Assessment Of Depressionmentioning

confidence: 99%

Section: Timing Of First Interview After Strokementioning

confidence: 99%