Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia

Quiles, Juan; Roy, Debashis; Gaze, David; Garrido, Iris P.; Avanzas, Pablo; Sinha, Manas; Kaski, Juan Carlos

doi:10.1016/s0002-9149(03)00638-6

Cited by 73 publications

(52 citation statements)

References 6 publications

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“…IMA increases in myocardial ischemia, cancers, infections, end-stage renal disease, liver disease, and cerebral ischemia (2)(3)(4)(5)(6)(7)(8)(9)(10)16). This study shows that serum IMA levels increase even in the absence of hypoxia markers in patients undergoing GTC seizures and that serum IMA values are directly proportional to length of seizure.…”

Section: Discussionmentioning

confidence: 99%

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

et al. 2017

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Background/aim: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures. Materials and methods:A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group. The patients' IMA, albumin, and IMA/albumin values at hours 0 and 1 following the episode were compared with control group values.Results: IMA levels in the patient group were significantly higher at hour 1 compared to hour 0, and were also significantly higher than those of the control group levels at hour 1. In addition, the patient group IMA/albumin index value at hour 1 was significantly higher than the baseline value. IMA levels increased significantly with length of seizure. Conclusion:Although there were no markers of hypoxia in patients undergoing GTC seizures in this study, hypoxia was observed to develop, and this caused serum IMA levels to rise in line with seizure duration.

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Section: Discussionmentioning

confidence: 99%

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

et al. 2017

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“…Concentrations of ischemia-modified albumin (IMA), 3 a new marker of myocardial ischemia, are increased after percutaneous coronary intervention (1)(2)(3). Moreover, in the percutaneous coronary intervention model, IMA production is higher in patients without collateral vessels than in those with collateral circulation; thus, IMA possibly reflects a protective effect of collateral vessels against percutaneous coronary intervention-induced myocardial ischemia (4 ).…”

confidence: 99%

Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

Roy¹,

Quiles²,

Sharma³

et al. 2004

Clinical Chemistry

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102

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Background: Ischemia-modified albumin (IMA) is a new marker of myocardial ischemia, there is concern that IMA concentrations may be affected by ischemia occurring in tissues other than the myocardium. Methods: We assessed 23 consecutive patients (15 males; mean age, 67 years) with typical leg claudication and documented peripheral vascular disease (PVD). All patients underwent both treadmill-exercise stress testing to induce leg ischemia and dobutamine stress echocardiography 1 week apart for the assessment of myocardial ischemia. Blood samples for IMA measurements were obtained at baseline, immediately after peak exercise/stress, and 1 h after exercise/stress. Statistical analysis was performed with the ANOVA repeated-measures test. Results: Compared with baseline, mean (SD) IMA was significantly lower after the induction of skeletal muscle ischemia and returned to baseline values at 1 h: baseline, 74.6 (15.6) kilounits/L; peak stress, 69.5 (14.0) kilounits/L (P <0.0001 vs baseline); 1 h after stress, 75.9 (15.7) kilounits/L (P <0.0001 vs peak stress; P ‫؍‬ 0.3 vs baseline). Baseline, peak stress, and 1-h poststress IMA concentrations were inversely correlated with the anklebrachial index after exercise (r ‫؍‬ ؊0.4; P <0.05). None of the patients showed regional wall motion abnormalities during dobutamine stress echocardiography, and IMA concentrations remained unchanged from baseline. There were no differences in baseline [74.6 (15.6) vs 72.7 (11.5) kilounits/L; P ‫؍‬ 0.6], peak stress, or poststress

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“…Elevated IMA levels have been shown in such ischemic events and hypoxemia (13,27,28). Previous studies have shown that IMA reflects the magnitude and duration of ischemia induced during percutaneous coronary intervention and exercise test for coronary syndrome, and that it is a sensitive marker for the identification of acute cardiac ischemia (29)(30)(31)(32). The most important characteristic that differentiates IMA from other cardiac ischemia markers is that it increases in the early phase.…”

Section: Discussionmentioning

confidence: 99%

Effect Of Nasal Continuous Positive Airway Pressure On Global Right Ventricular Myocardial Performance In Patients With Obstructive Sleep Apnea Syndrome

Öztuna¹

2013

Turk J Med Sci

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Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia

Cited by 73 publications

References 6 publications

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?

Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

Effect Of Nasal Continuous Positive Airway Pressure On Global Right Ventricular Myocardial Performance In Patients With Obstructive Sleep Apnea Syndrome

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