Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

Roy, Debashis; Quiles, Juan; Sharma, Rajan; Sinha, Manas; Avanzas, Pablo; Gaze, David; Kaski, Juan Carlos

doi:10.1373/clinchem.2004.031690

Cited by 102 publications

(63 citation statements)

References 20 publications

(19 reference statements)

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“…Molecular markers that are able to improve diagnosis are required to reduce ACVD mortality. IMA, derived from human serum albumin (HSA), is an important molecular marker in cardiac care due to its association with ischemic events (19). The amino-terminal sequence of HSA, which is unique to humans, is the major binding site of transition metals, including Co, Cu and Ni.…”

Section: Discussionmentioning

confidence: 99%

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

et al. 2012

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Abstract. Acute cerebrovascular disease (ACVD) is associated with high morbidity and mortality rates, however, molecular markers to aid in its early detection are lacking. In this study, we examined the correlation between serum ischemia-modified albumin (IMA), a marker used to identify ischemic events in the heart, and blood lipids in patients with ACVD. Serum IMA levels were determined by enzyme-linked immuno sorbent assay, and total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL) and triglyceride (TG) levels were determined biochemically in 62 patients with cerebral infarction (CI), 40 patients with intracerebral hemorrhage (ICH), 18 patients with subarachnoid hemorrhage (SAH) and 100 healthy individuals (controls). Serum IMA levels were significantly higher in each of the ACVD groups compared to the control group (CI, 80.81±11.97 U/ml; ICH, 80.25±10.91 U/ml; SAH, 74.43±11.39 U/ml and control, 41.08±5.10 U/ml; P<0.05). Additionally, serum TC, LDL and TG levels significantly increased, while serum HDL significantly decreased in the ACVD groups compared to the control group (P<0.05). A positive correlation was found between serum IMA levels and serum TC, LDL and TG levels in the ACVD patients, while serum IMA levels were negatively correlated with serum HDL levels (P<0.05). Thus, serum IMA increased following an ACVD event and was closely correlated with changes in the blood lipid levels. These factors, when combined, may allow the development of molecular markers for an earlier diagnosis of ACVD.

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Section: Discussionmentioning

confidence: 99%

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

et al. 2012

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“…Middleton et al generated similar results in a study conducted in the London marathon in 2004 [16]. Roy et al observed that IMA levels during muscle ischemia caused by exercise decreased below basal levels [17]. Piechota et al [5] detected a reduction in IMA levels after exercise in patients previously diagnosed with coronary atherosclerosis.…”

Section: Ischemia-modified Albumin Levels In Soccer Playersmentioning

confidence: 75%

“…One of the issues debated in this context is lactate interference. It has been reported that lactate levels, which increase due to exercise, reduce IMA values [17,18].…”

Section: Ischemia-modified Albumin Levels In Soccer Playersmentioning

confidence: 99%

Ischemia-modified Albumin Levels In Professional Male Soccer Players Before And After Training

Duman

Çolak

Bamaç

et al. 2013

MMJ

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Objectives:The ischemia-modified albumin (IMA) test is a promising indicator of myocardial ischemia in the early diagnosis of the acute coronary syndrome (ACS). Recent studies examining alterations in IMA levels caused by myocardial ischemia that develops during exercise have shown contradictory results. There has been an increase in severe exercise-related cardiac events in football. We therefore, assessed IMA levels before and after exercise in professional soccer players in order to examine the effect of the exercise on IMA levels.Methods: Blood was collected from professional soccer players before and after exercise. IMA levels were measured by using spectrophotometric methods, and the albumin levels were measured in an autoanalyzer.Results: The average pre-and post exercise IMA levels of 16 soccer players were found to be 0.438±0.071 and 0.386±0.069, respectively. The pre-and post exercise albumin levels of the same group were 4.08±0.20 g/dL and 4.21±0.19 g/dL, respectively. There was a strong negative correlation between post exercise IMA and albumin levels, which was statistically significant (r = -0.535. p = 0.033).Conclusion: IMA levels should be examined not only in noncardiac pathologies, but also in specific serum albumin concentrations and in individuals practicing vigorous sport activities.

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“…Isc he mi a mo di fied al bu min (IMA) me a su re ment re fer red as al bumin co balt bin ding test (ACB) is a new bi o mar ker of car di ac isc he mi a, ske le tal musc le isc he mi a and ce reb ral isc he mi a. [13][14][15] To in ves ti ga te the cli ni cal uti lity of IMA as a se rum mar ker for MTBI, we attemp ted to eva lu a te the ro le of IMA in rats with clo sed he ad MTBI.…”

Section: Ischemia Modified Albumin Levels Following Mild Closed Head mentioning

confidence: 99%

Ischemia Modified Albumin Levels Following Mild Closed Head Trauma in the Rat

Çolak¹,

Duman²,

Bamaç³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Mild tra u ma tic bra in in jury (MTBI) is one of the most fre qu ent ne u ro logi cal da ma ge types in which comp lex physi o lo gi cal and bi oc he mi cal events oc cur in tra u ma ti zed are a. Re gi o nal isc he mi a can oc cur in the acu te pha se af ter tra u ma. Re cently, both cli ni cal and expe ri men tal stu di es ha ve shown that isc he mi a mo di fi ed al bu min (IMA) is one of the most pro mising blo od mar kers of isc he mi a. In this study, whet her se rum IMA va lu es can be used in rats as a mar ker for in trac ra ni al isc he mi a ca u sed by tra u ma is investigated. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Wis taral bi no adult rats we re uti li zed in this study. Rats we re ex po sed to MTBI by using a tra u ma de vice. Fron tal and pa ri e tal bra in tis su es we re ta ken for his to pat ho lo gi cal in ves ti ga ti on. Se rum IMA va lu es of tra u ma ti sed and con trol rats we re me a su red with the ACB (al bu min co balt bin ding) test. R Re e s su ul lt ts s: : Whi le the ab so lu te IMA va lu es we re 0.576 ± 0.048 for tra u ma gro up, it was iden ti fi ed as 0.568 ± 0.055 for con trol gro up. The re was no sta tis ti cally sig ni fi cant dif fe ren ce bet we en tra u ma and con trol gro ups in the me an va lu e of the IMA. In our his to pat ho lo gi cal analy sis, nec ro sis as soci a ted with hypo xi a in the ou ter la yers of bra in cor tex as a re sult of the tra u ma app li ed to rats, and ne u ron da ma ge in the in ner la yers of the cor tex we re ob ser ved. In ad di ti on, red ne u rons we re de tec ted in the bra in cor tex as a re sult of early sta ge ne u ron da ma ge as so ci a ted with isc he mi a. C Co on nc c l lu u s si i o on n: : We fo und that the re is no sig ni fi cant in cre a se in IMA le vels in rats with tra u ma sugges ting that this bi o mar ker wo uld not be use ful in de tec ting early isc he mic chan ges in MTBI.K Ke ey y W Wo or rd ds s: : Rats; cra ni o ce reb ral tra u ma Ö ÖZ ZE ET T A Am ma aç ç: : Ha fif trav ma tik be yin ha sa rı (HTBH) en sık gö rü len nö ro lo jik ha sar lar dan bi ri dir ve trav ma ti ze alan da komp leks fiz yo lo jik ve bi yo kim ya sal olay lar oluş tu rur. Böl ge sel is ke mi trav madan son ra ki akut faz da gö rül mek te dir. Son za man lar da kli nik ve de ney sel ça lış ma lar iske mi mo difi ye al bu min (IMA)'in, is ke mi de en umut ve ri ci kan be lir teç le rin den bi ri ol du ğu nu gös ter miş tir. Ça lış ma da rat lar da se rum IMA de ğer le ri nin trav ma so nu cu olu şan ka fa i çi is ke mi de be lir teç ola rak kul la nı lıp kul la nı la ma ya ca ğı araş tı rıl dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Araş tır ma da Wis tar-al bi no tü rü eriş -kin rat lar kul la nıl dı. Rat lar trav ma dü ze ne ği kul la nı la rak HTBH'a ma ruz bı ra kıl dı. His to pa ta lo jik araş tır ma için fron tal ve pa ri e tal be yin do ku la rı alın dı. Trav ma ti ze ve kon trol rat la rın se rum IMA de ğer le ri al bu min ko balt ...

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Ischemia-Modified Albumin Concentrations in Patients with Peripheral Vascular Disease and Exercise-Induced Skeletal Muscle Ischemia

Cited by 102 publications

References 20 publications

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease

Ischemia-modified Albumin Levels In Professional Male Soccer Players Before And After Training

Ischemia Modified Albumin Levels Following Mild Closed Head Trauma in the Rat

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