Relation of Hyperuricaemia, Renal Function and Arterial Hypertension in a Large Region of the Eastern Siberia Inhabitants

Гринштейн, Ю. И.; Шабалин, В. В.; Руф, Р. Р.; Петрова, М. М.; Артюхов, И. П.; Шальнова, С. А.

doi:10.15829/1560-4071-2017-6-86-91

Russ J Cardiol

2017

DOI: 10.15829/1560-4071-2017-6-86-91

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Relation of Hyperuricaemia, Renal Function and Arterial Hypertension in a Large Region of the Eastern Siberia Inhabitants

Ю. И. Гринштейн¹,

В. В. Шабалин²,

Р. Р. Руф³

et al.

Abstract: Цель. Изучить распространенность гиперурикемии (гУ) среди городского и сельского населения Красноярского края, а также выявить возможную взаи-мосвязь между гУ и артериальной гипертонией (аг), гУ и функцией почек. Материал и методы. Исследование, проводившееся в рамках эссЕ-РФ, включало 1603 человека 25-64 лет, отобранных путем случайной трехступенча-той стратифицированной выборки. Все включенные подвергались анкетиро-ванию, офисному измерению ад. Уровень мочевой кислоты (МК) определялся уреазным методом на ана… Show more

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Cited by 3 publications

References 12 publications

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The prevalence of metabolic syndrome in the Krasnoyarsk Krai population and the features of its association with hyperuricemia

et al. 2020

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Aim. To study the prevalence of metabolic syndrome (MS) and its components, as well as their relationship with hyperuricemia (HU) in a representative sample of the Krasnoyarsk Krai.Material and methods. As part of a multicenter epidemiological study ESSE-RF, a representative sample of 1603 residents of the Krasnoyarsk Krai aged 25-64 was randomized. All subjects underwent a questionnaire survey, anthropometry, office blood pressure (BP) measurement, determining the levels of blood lipids, plasma glucose and serum uric acid. MS was diagnosed according to the modified NCEP ATP III criteria (2005). Statistical processing was carried out using the software package IBM SPSS v 22.Results. The total prevalence of MS was 26,8%; higher in women than in men (29,4% vs 22,9%). With age, the prevalence of MS significantly increased — from 6,9% in subjects aged 25-34 years to 45,2% in people 55-64 years old. The prevalence of MS was significantly higher among rural residents compared with urban ones (36,8% vs 23,1%). Education level significantly affected prevalence of MS: in people with basic education, MS was found in 35,7%, with secondary — in 30,3%, with higher — in 17,8%. Regression analysis showed that hypertriglyceridemia, blood pressure >130/85 mm Hg and glucose ≥5,6 mmol/l were a significant predictors of HU in all subjects. For men, significant predictors of HU were hypertriglyceridemia and abdominal obesity, and for women — glucose ≥5,6 mmol/l and lipid-lowering therapy.Conclusion. The prevalence of MS in the Krasnoyarsk Krai, according to the modified NCEP ATP III criteria (2005), is 26,8%. MS is more often recorded in women than in men and in rural residents than in urban ones. With an increase in the education level, MS is less common. With age, the prevalence of MS significantly increases. The correlation of HU is not revealed with all the components of MS and has sex differences.

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The prevalence of metabolic syndrome in the Krasnoyarsk Krai population and the features of its association with hyperuricemia

et al. 2020

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Circulating biomarkers for the hypertension development predicting: are there any prospects?

Protasov

2023

Arter. gipertenz.

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The problem of finding reliable predictors of the arterial hypertension (HTN) development in people with initially normal blood pressure level has not been resolved yet. Objective. The purpose of this review was to present and analyze current data on the role and prospects for the use of circulating serum biomarkers in predicting the HTN development. To establish the predictive value of biomarkers and their causal relationships with HTN, the results of prospective and retrospective cohort studies, studies of Mendelian randomization, randomized controlled trials, systematic reviews and meta-analyses on the study of both previously known and relatively new potential risk factors for HTN were analyzed: uric acid, vitamin D, homocysteine, inflammatory biomarkers, soluble ST2, natriuretic peptides, and cardiac troponins. There is evidence of an independent prognostic value of uric acid and inflammatory biomarkers (C-reactive protein) in the HTN development and the possibility of their use as risk markers of HTN. Despite the found relationships of all considered biomarkers with the level of blood pressure in cross-sectional and experimental studies, their causal role in the HTN development in studies of a high level of evidence has not received unambiguous confirmation.

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Polymorphism in folate cycle genes in patients with gout in the Russian population of Trans-Baikal Territory

Kushnarenko

Mishko

Medvedeva

2020

SMJ

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Заключение. В результате проведенного исследования обнаружены значительные различия в распределении частот генотипов и аллелей генов MTHFR С677T и MTR А2756G у больных подагрой по сравнению с контрольной группой. Наличие минорного аллеля T и генотипа T/T гена MTHFR С677T, минорного аллеля G и генотипа А/G гена MTR A2756G ассоциировано с повышенным риском развития подагры, в то время как носительство аллеля С локуса С677Т гена MTHFR, аллеля А и генотипа А/А гена MTR А2756G, вероятно, имеет протективный характер.

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Relation of Hyperuricaemia, Renal Function and Arterial Hypertension in a Large Region of the Eastern Siberia Inhabitants

Cited by 3 publications

References 12 publications

The prevalence of metabolic syndrome in the Krasnoyarsk Krai population and the features of its association with hyperuricemia

The prevalence of metabolic syndrome in the Krasnoyarsk Krai population and the features of its association with hyperuricemia

Circulating biomarkers for the hypertension development predicting: are there any prospects?

Polymorphism in folate cycle genes in patients with gout in the Russian population of Trans-Baikal Territory

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