Relation of Helicobacter pylori infection and coronary heart disease.

Abstract

Background-There is evidence suggesting that early life experience may influence adult risk of coronary heart disease (CHD). Chronic bacterial infections have been associated with CHD. Objective-To determine whether Helicobacter pylori, a childhood acquired chronic bacterial infection, is associated with an increased risk of coronary heart disease in later life. We used a case-control comparison to investigate whether H pylori infection was associated with adult CHD. We also studied possible associations of Hpylori infection with cardiovascular risk factors in the control population. Patients and methods PATlENTSWe studied men aged 45-65. The controls came from a single general practice screening clinic and the cases from a series of consecutive patients referred to the cardiology clinic of a local teaching hospital with angiographically confirmed CHD (stenosis >70% in one coronary artery). Potential controls were excluded if they had a firm diagnosis of CHD. METHODSAll subjects completed a questionnaire and 10 ml of serum was drawn and stored at -20°C. Blood pressure was measured in the general practice when the patient was seated. One observer used the same mercury sphygmomanometer throughout the study.We measured H pylori specific IgG antibody titres by an in-house enzyme linked immunoadsorbent assay (ELISA) in duplicate, using a partially purified antigen as described previously. Results were analysed by multiple logistic regression using GLIM7 and multiple regression using the GLM proceedure in SAS. In the logistic regression models, age was grouped into four categories (45-49, 50-54, 55-59, 60-65) and current social class was grouped into six categories according to the Registrar-General's 1980 classification.

Seroepidemiology of Helicobacter pylori infection in a Jamaican community

“…Further, a wealth of clinical evidence has established that H. pylori is causally related to peptic ulcer disease, but is also associated with conditions ranging from intermittent nausea and vomiting to gastric carcinoma/lymphoma and, possibly, ischaemic heart disease (Forman et al 1991;Mendall et al 1994;NIH 1994;Parsonnet et al 1994).…”

The effects of Helicobacter pylori infection on intraocular pressure in anterior uveitis

“…7 Helicobacter pylori (H. pylori) is a common, curved, spiral, Gram-negative bacteria that has been associated with various extradigestive disorders, in addition to its well-known association with gastrointestinal disorders. [8][9][10][11] In the past year, several studies have suggested an association between H. pylori infection and various extradigestive diseases, including cardiovascular and immunological disorders. As the release of large amounts of various proinflammatory and vasoactive substances, such as cytokines, eicosanoids, and acute phase reactant proteins follows gastric colonization by H. pylori, the bacterium may be involved in vascular disorders.…”

Aspects infectieux de l’athérosclérose

“…< [5]. En 1994, une autre série annonçait une association entre maladie coronaire et infection par Helicobacter pylori [6]. Publiés en 1997, deux essais cliniques pilotes [7,8] ont suggéré qu'un traitement antibiotique par macrolide améliore le pronostic de la maladie coronaire.…”

“…Il est donc possible de rechercher des associations entre la signature sérolo-gique d'une infection microbienne et l'existence (études cas-témoins) ou la survenue (études prospectives de cohorte) d'une maladie coronaire. Cette méthode a mené à impliquer C. pneumoniae [4] ou H. pylori [6]. Toutefois, l'épidémiologie établit des associations statistiques où le lien de causalité n'est jamais qu'une interprétation parmi d'autres [1].…”