Seroepidemiology of Helicobacter pylori infection in a Jamaican community

Lindo, John; Lyn-Sue, Alicia; Palmer, Carol; Lee, M. G.; Vogel, Philip J.; Robinson, R. D.

doi:10.1046/j.1365-3156.1999.00480.x

Cited by 17 publications

(14 citation statements)

References 29 publications

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“…This is in agreement to that reported in the previous studies done in Ethiopia (56-70%) (17)(18) and in some other developing countries (36-81%) (19)(20), but lower than that reported in recent studies in Ethiopia (69-91%) (10,21). However, there are reports from different parts of the world with lower prevalence of H. pylori infection e.g.…”

Section: Discussionsupporting

confidence: 93%

Serioprevalence of Helicobacter pylori Infection in and its Relationship with ABO Blood Groups

Tadege¹,

Mengistu²,

Desta³

et al. 2005

Ethiopian Journal of Health Development

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Background: Helicobacter pylori infection occurs worldwide, but the prevalence varies greatly among countries and among population groups studied. People with blood group O have been noted to be more susceptible to H. pylori infection. Objectives: To determine the magnitude of H. pylori infection in adult patients with and without dyspeptic symptoms attending Felege Hiwot Hospital, Bahir Dar, North West Ethiopia. We also prospectively examined the relationship between H. pylori infection and ABO blood groups in those subjects to clarify the possible association. Methods: A case-control study was conducted between dyspeptic (n=100) and non-dyspeptic patients (n=100) for the presence of H. pylori infection between mid November 2002 and March 2003 by using serology. Results: Of the total 200 subjects, 128 (64%) were males and 72 (36%) females with mean age of 32.7, range 15-75, years. Of these, 112 (56%) and 66 (33%) were found positive and negative for H. pylori infection, respectively, by EIA. Borderline values were measured in 22/200 (11%). H. pylori infection was detected in 124/200 (62%) of study subjects by immunoblot. The most prevalent blood group was type O (43%), followed by A (23.5%), B (22.5%) and AB (11%). In comparison of the subjects with blood group O and the other blood groups, no statistical significance could be identified in the seroprevalence of H. pylori ( p>0.05). Conclusion:The overall seroprevalence of H. pylori infection in Bahir Dar in this study was between 63% and 70% in dyspeptic patents and 49% and 54% in non-dyspeptic patients by EIA and IB, respectively. There were no statistically significant differences in the frequency of H. pylori seroprevalence between dyspeptic and non-dyspeptic patients. There was no statistically significant association between H. pylori infection and sex, age and ABO blood groups. Thus, further investigations along this line are recommended. [Ethiop.J.Health Dev. 2005;19(1):55-59]

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Section: Discussionsupporting

confidence: 93%

Serioprevalence of Helicobacter pylori Infection in and its Relationship with ABO Blood Groups

Tadege¹,

Mengistu²,

Desta³

et al. 2005

Ethiopian Journal of Health Development

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“…In our series, 18 (60%) of the 30 patients were positive for H. pylori by one or more biopsy-based methods, whereas 21 (70%) of our patients were positive by serologic assay. The seroprevalence of 70% is similar to previously reported values for H. pylori infection in Jamaica and Barbados (2,8,9). Two of the three discordant results of H. pylori infection status determined by serologic and biopsy-based methods were seen in gastric cancer patients with chronic atrophic changes.…”

Section: Pylori Infection In Jamaican Adults 213supporting

confidence: 87%

Characteristics of Helicobacter pylori Infection in Jamaican Adults with Gastrointestinal Symptoms

et al. 2001

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Helicobacter pylori infection is common in Jamaica. Describing its epidemiology in a population-based study depends largely on serology, but serologic assays have not been validated in this population. To address this issue, we examined the presence of H. pylori infection in 30 sequential adult patients with gastroduodenal symptoms by three biopsy-based methods (rapid urease test, histology, and culture) as well as by one research and two commercial enzyme-linked immunosorbent assays (ELISAs). A patient was considered H. pylori positive if the organism was detected by at least one biopsy-based method. Eighteen (60%) of the 30 patients were H. pylori positive by these criteria, whereas 21 (70%) were seropositive for H. pylori immunoglobulin G by our research ELISA. The presence of H. pylori infection in patients with gastric cancer and those with chronic gastritis was missed by biopsy-based methods but was detected by serologic assays. This observation indicates that serologic assays may be better suited for the detection of this infection in a population in which H. pyloriassociated pathology is prevalent. The performance of our research ELISA in detecting biopsy-based H. pyloripositive cases was excellent, with a sensitivity and specificity of 100% and 75%, respectively. Molecular genotyping of the isolates revealed that the predominant H. pylori genotypes in this cohort of Jamaicans were cagA ؉ vacA slb-m1, and iceA2. The validated serologic assay enables us to interpret epidemiologic data from population-based studies in Jamaica by comparison to those from other populations.Helicobacter pylori is a common human gastric pathogen causing chronic gastritis and duodenal ulcers (6, 12). There is strong evidence that H. pylori infection is also associated with gastric cancers and gastric lymphomas (6, 13). Both the prevalence of H. pylori infection and the incidence of gastric cancer are higher in Asia, South America, and the Caribbean than in Europe and the United States. The prevalence of H. pylori infection is also higher among blacks than among caucasians in the United States (10). Because H. pylori infection persists for life in the absence of treatment (6), its clinical sequelae continue to present a major public health burden in areas in which this bacterium is endemic.One of the challenges in epidemiologic studies of H. pylori infection has been the population-specific performance of serologic assays, which has made it difficult to interpret existing data across populations. Variations in bacterial genotype, antigen selections for the immunoassays employed, and host immune responses may affect the performance of serologic assays and their suitability for particular populations.In the present study of Jamaican patients, we evaluated the performance of two commercial enzyme-linked immunosorbent assays (ELISAs) for immunoglobulin G (IgG) antibody to H. pylori and a research ELISA which had been validated in epidemiologic investigations of populations from diverse geographic regions (5, 7, 26). We also describe...

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“…Although there was no significant difference in the seropositivity between dog owners and the other group, contact with dogs was identified as a risk factor for acquiring H. pylori infection in other studies [36,37]. Similar to our findings, in other seroepidemiological studies, the exact relationship between pet ownership and human seropositivity cannot be clearly established [38,39].…”

Section: Discussionsupporting

confidence: 76%

Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

Elhariri

Elhelw

Hamza

et al. 2017

J Infect Dev Ctries

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Introduction: Helicobacter pylori (H. pylori) is one of the most common bacterial infections among humans worldwide. Although many records imply its interfamilial acquisition, the role of animals remains poorly understood. This study was undertaken to investigate the seroprevalence of H. pylori in animals and their human contacts in Cairo and Giza governorates, Egypt. Methodology: Commercial enzyme-linked immunosorbent assay (ELISA) kits were used to detect IgG antibodies to H. pylori in dogs, cattle, and humans. Results: Seropositive dogs (35/94; 37.2%), cattle (24/80; 30%) and humans (40/90; 44.4%) were found. Seroprevalence in animals significantly varied in different areas of sample collection, but there was no association with sex or age. Human seropositivity rates were associated with increasing age; moreover, seropositive dog owners (51.7%; 15/29), had seropositive dogs. However, infection was not associated with subject's sex, occupation, or history of animal contact. Conclusions: Our findings indicate H. pylori is widely distributed in cattle and dogs and their human contacts in Cairo and Giza, Egypt. Further studies to determine infection in other occupational groups are needed. This study provides baseline information on the seroprevalence of H. pylori, which may be required to begin prevention control programs in our area.

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Seroepidemiology of Helicobacter pylori infection in a Jamaican community

Cited by 17 publications

References 29 publications

Serioprevalence of <i>Helicobacter pylori</i> Infection in and its Relationship with ABO Blood Groups

Serioprevalence of <i>Helicobacter pylori</i> Infection in and its Relationship with ABO Blood Groups

Characteristics of Helicobacter pylori Infection in Jamaican Adults with Gastrointestinal Symptoms

Serologic evidence and risk factors for Helicobacter pylori infection in animals and humans

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