Relation of epicardial adipose tissue and carotid intima-media thickness in patients with nonalcoholic fatty liver disease

Abstract

Our findings indicate that EFT and C-IMT were significantly higher in patients with NAFLD compared with the controls and waist circumference and C-IMT are independent predictors for EFT in patients with NAFLD.

Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: Association with the severity of liver disease

“…In the last years growing evidence also suggests that the increase in epicardial fat can be considered a cardiometabolic risk factor [32], being associated with the metabolic syndrome [33], with a diagnosis of NAFLD both by US or MR spectroscopy [14][15][16][17][18], with carotid atherosclerosis [34] and coronary artery disease [35]. Accordingly, we confirmed the association of epicardial fat thickness with older age, visceral obesity, hypertension and statin use, well-known factors associated with an increased cardiovascular risk.…”

“…The complex interplay between liver fat and heart function has been further demonstrated by studies reporting an association between NAFLD and epicardial fat thickness. Epicardial fat thickness, assessed by either magnetic resonance imaging (MRI) [14] or echocardiography [15,16] was higher in NAFLD subjects compared to non-NAFLD, and a correlation was reported between epicardial fat thickness and ALT levels [17], the severity of ultrasonographic (US) [15] or MR spectroscopy [18] steatosis, and the Nonalcoholic Activity Score (NAS) in un-adjusted analyses [16].…”

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

“…For example, epicardial fat thickness is associated with NAFLD and hepatic fibrosis severity, independent of visceral adiposity. [143][144][145][146] The same is true for dorso-cervical fat. 147 The association of NAFLD with other forms of ectopic fat deposition may not only translate into more serious "adiposopathy", but also contribute to the pathogenesis of liver disease.…”

Epicardial Adipose Tissue Thickness, Is It a Reason or a Consequence?

“…1 As Dr Eyüboglu mentioned, EAT has an independent correlation with metabolic syndrome, 2 waist circumference, 3 and nonalcoholic fatty liver disease. 4 In our study, body mass index of patients with impaired flow group was significantly greater than the normal flow group. Other metabolic syndrome risk factors such as smoking, diabetes, and hypertension were more prominent in patients with impaired flow.…”