Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: Association with the severity of liver disease

Petta, Salvatore; Argano, Christiano; Colomba, Daniela; Cammà, Calogero; Marco, Vito Di; Cabibi, Daniela; Tuttolomondo, Antonino; Marchesini, Giulio; Pinto, Antonio; Licata, Giuseppe; Craxı̀, Antonio

doi:10.1016/j.jhep.2014.11.030

Cited by 157 publications

(120 citation statements)

References 38 publications

(54 reference statements)

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“…On multivariate analysis only early diastolic velocity, assessed on tissue Doppler imaging was found to be associated with NAFLD. This has also been found by other centers [35][36][37][38][39][40][41] . Furthermore this may be an early consequence of NAFLD.…”

Section: Nafld and Left Ventricular Functionsupporting

confidence: 84%

“…The heart rate recovery index is deteriorated in patients with NAFLD Petta et al [41] Anthropometric, biochemical and metabolic of 147 consecutive biopsy-proven NAFLD cases Diastolic posterior-wall thickness, left ventricular mass, relative wall thickness, left atrial volume, as well as ejection fraction, lower lateral TDI e', E/A ratio and epicardial fat linked to severe liver fibrosis Mantovani et al [42] 116 consecutive patients with hypertension and type 2 diabetes. US diagnosed NAFLD, LVH diagnosed by TT echo LVH higher among diabetic patients with NAFLD.…”

Section: Ref Methods Resultsmentioning

confidence: 99%

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Non-alcoholic fatty liver disease - the heart of the matter

Azzam

Malnick

2015

WJH

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease in the Western world. There is a close association with the metabolic syndrome and NAFLD is considered to be the hepatic manifestation of the metabolic syndrome. The components of the metabolic syndrome include hypertension, obesity and insulin resistance which are well established cardiovascular risk factors. The mortality rate of NAFLD patients from myocardial infarction is higher than that in the general United States population and there is also an increased risk of nonfatal cardiovascular events. This article reviews the cardiovascular complications associated with NAFLD. In order to provide comprehensive care of NAFLD patients, physicians need to be aware of, and search for, the cardiac morbidity associated with NAFLD. Core tip: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Due to the overlapping cardiovascular risk factors in the metabolic syndrome, there are cardiovascular consequences linked to the presence of NAFLD in a patient. We review these complications and also a less well appreciated complication of diastolic dysfunction that is intimately associated with NAFLD. Physicians looking after NAFLD patients need to be aware of these complications and actively search for and treat them.Azzam H, Malnick S. Non-alcoholic fatty liver disease -the heart of the matter. World J Hepatol 2015; 7(10):

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Section: Nafld and Left Ventricular Functionsupporting

confidence: 84%

Section: Ref Methods Resultsmentioning

confidence: 99%

Non-alcoholic fatty liver disease - the heart of the matter

Azzam

Malnick

2015

WJH

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“…To date, a number of case-control studies have demonstrated that nondiabetic patients with NAFLD, both adults and children/adolescents, have echocardiographic features of early LVDD compared with their counterparts without NAFLD [9,[31][32][33][34][35][36][37]. These myocardial functional abnormalities appear to be independent of multiple cardio-metabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Mantovani

Pernigo

Bergamini

et al. 2015

Digestive and Liver Disease

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“…For example, epicardial fat thickness is associated with NAFLD and hepatic fibrosis severity, independent of visceral adiposity. [143][144][145][146] The same is true for dorso-cervical fat. 147 The association of NAFLD with other forms of ectopic fat deposition may not only translate into more serious "adiposopathy", but also contribute to the pathogenesis of liver disease.…”

mentioning

confidence: 81%

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Lonardo

Bellentani

Argo

et al. 2015

Digestive and Liver Disease

393

318

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We aimed to illustrate the epidemiology of nonalcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published through May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidemia", "familial heterozygous hypobelipoproteinemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".We found that age, sex and ethnicity are major physiologic modifiers of the risk of nonalcoholic fatty liver disease, along with belonging to "nonalcoholic fatty liver disease families" and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of nonalcoholic fatty liver disease risk. Compared to these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of nonalcoholic fatty liver disease.A better understanding of the epidemiology of nonalcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups.

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Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: Association with the severity of liver disease

Cited by 157 publications

References 38 publications

Non-alcoholic fatty liver disease - the heart of the matter

Non-alcoholic fatty liver disease - the heart of the matter

Nonalcoholic fatty liver disease is independently associated with early left ventricular diastolic dysfunction in patients with type 2 diabetes

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

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