Relation of Electrolyte Changes and Adrenocortical Activity to Paralytic Ileus

Streeten, David H. P.; Ward‐McQuaid, J. N.

doi:10.1136/bmj.2.4784.587

Cited by 23 publications

(5 citation statements)

References 12 publications

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“…The study also highlighted the problem of inadequate K ? supplementation in surgery patients, in agreement with previous reports [3][4][5]20]. Hypokalaemia increases the risks of complications such as a prolonged intestinal ileus and cardiac arrhythmias [21,22].…”

Section: Discussionsupporting

confidence: 90%

Hypo‐ and Hypernatraemia in Surgical Patients: Is There Room for Improvement?

et al. 2009

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Section: Discussionsupporting

confidence: 90%

Hypo‐ and Hypernatraemia in Surgical Patients: Is There Room for Improvement?

et al. 2009

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“…The absence of differences between the drug studies and those of the initial ileus procedure indicate that any changes were caused by the operative procedure itself rather than cause or effect of the gut motility changes. They may have been a response to general surgical trauma (Streeten and Ward-McQuaid 1952;Walker and Watt 1967) and/or the loss of fluid and electrolytes from the traumatised intestine (Beard and Blalack 1932;Adel, Abels, Pack and Rhoads 1943).…”

Section: Plasma Biochemistry Resultsmentioning

confidence: 99%

“…In terms of electrolyte imbalances, hypochloraemia is a more likely contributing factor which has received little attention to date. In man, a marked decrease in chloride is similarly present in clinical cases and replacement therapy is necessary for return of gastrointestinal propulsion (Oschner, Gage and Cutting 1933;Levy and Nora 1946;Streeten and Ward-McQuaid 1952). Chloride removal has been shown to inhibit contractions of guinea pig smooth muscle in vitro (Rangachari, Triggle and Daniel 1982).…”

mentioning

confidence: 99%

Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Gerring

Hunt

1986

Equine Veterinary Journal

109

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Summary An experimental model of postoperative ileus was developed in ponies using trauma to, and exposure of, a length of small intestine which gave rise to a reproducible and reversible set of changes in gut activity. This was assessed by recordings of electrical and mechanical activity and by propulsion of spheres from stomach to anus. Activity was depressed, especially in the stomach and colon, and transit was slowed. All drugs given increased electromechanical activity but propranolol was the least effective and did not alter the delayed transit of spheres. Yohimbine was more effective and the addition of bethanechol produced a little extra propulsive action. Metoclopramide had the best effect, virtually returning transit to normal and was the only drug fully restoring coordination of gastric and small intestinal activity which was disrupted by the ileus procedure. Loss of gastroduodenal coordination is probably the central lesion in equine ileus and may be mediated by dopamine.

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“…Postoperative ileus is often fatal (85.7 per cent mortality rate Also, in a survey by Streeten and Ward-McQuaid (1952) of in Cases surveyed); therefore, early diagnosis of the condition humans, the majority of patients with postoperative ileus had and, if possible, of the cause is essential. The clinical course of a blood eosinopenia attributed to adrenocortical hyperactivity, postoperative ileus is similar following both large and small If this was a constant finding in equine idiopathic intestinal surgery cases but tends to be protracted in the postoperative ileus but not other postoperative ileus cases, former.…”

Section: Postoperative Ileusmentioning

confidence: 99%