1986
DOI: 10.1111/j.2042-3306.1986.tb03618.x
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Pathophysiology of equine postoperative ileus: Effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model

Abstract: Summary An experimental model of postoperative ileus was developed in ponies using trauma to, and exposure of, a length of small intestine which gave rise to a reproducible and reversible set of changes in gut activity. This was assessed by recordings of electrical and mechanical activity and by propulsion of spheres from stomach to anus. Activity was depressed, especially in the stomach and colon, and transit was slowed. All drugs given increased electromechanical activity but propranolol was the least effect… Show more

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Cited by 107 publications
(103 citation statements)
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“…When fresh digesta are offered, the stomach initiates soft peristaltic contractions and most of the old digesta are leaving to the duodenum (Gerring and Hunt, 1986). Nevertheless, the stomach is rarely completely empty.…”
Section: Anatomy and Motility Of The Gastrointestinal Tractmentioning
confidence: 99%
“…When fresh digesta are offered, the stomach initiates soft peristaltic contractions and most of the old digesta are leaving to the duodenum (Gerring and Hunt, 1986). Nevertheless, the stomach is rarely completely empty.…”
Section: Anatomy and Motility Of The Gastrointestinal Tractmentioning
confidence: 99%
“…[1][2][3][4] In horses, ileus is characterized by a loss of gastroduodenal coordination and a failure of intestinal propulsive contractile activity, producing gastric reflux and intestinal distention with fluid, ingesta, and gas. 1 The reported incidence of POI in horses varies from 16 to 43% with a mortality rate as high as 86%. [2][3][4] Factors such as endotoxemia, distention, and inflammation have been implicated in the development of POI.…”
Section: P Ostoperative Ileus (Poi) Is a Common Complicationmentioning
confidence: 99%
“…Horses with alter significantly arterial pressure. However, dopaminergic idiopathic postoperative ileus appear to be in less pain than hyperactivity is probably the pivotal factor in postoperative those with postoperative strangulation obstruction (most ileus (Gerring and Hunt 1986) and its use, therefore, should painful), adhesions or impactions. Animals with necrosis of not be routine.…”
Section: Shockmentioning
confidence: 99%