Relation of autonomic modulation to recurrence of atrial fibrillation following cardioversion

Kanoupakis, Emmanuel M.; Manios, Emmanuel G.; Mavrakis, Hercules E.; Kaleboubas, Michail D.; Parthenakis, Fragiskos I.; Vardas, Panos

doi:10.1016/s0002-9149(00)01129-2

Cited by 35 publications

(19 citation statements)

References 22 publications

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“…This association has been partially explained by the close positioning of the left atrium and esophagus. Overstimulation of the vagus nerve induced by GERD is another postulated mechanism [14]. In our case the mechanism seems to be the other way around.…”

Section: Contents Lists Available At Sciencedirectsupporting

confidence: 49%

An extremely rare presentation of supraventricular tachycardia: Burping

Yetkın¹

2015

International Journal of Cardiology

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Section: Contents Lists Available At Sciencedirectsupporting

confidence: 49%

An extremely rare presentation of supraventricular tachycardia: Burping

Yetkın¹

2015

International Journal of Cardiology

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“…First, GERD could induce vagal nerve stimulation [29], [30]. Accumulating evidence now suggests that the induction of AF may be related to vagal nerve overstimulation [31], [32] and vagal nerve-mediated parasympathetic stimulation [33]. Therefore, vagal nerve overstimulation, which has been observed in patients with GERD, may be responsible for the association between GERD and an increased risk of AF.…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

et al. 2012

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ObjectivesPrecise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF.Methods and ResultsPatients with GERD were identified from the 1,000,000-person cohort dataset sampled from the Taiwan National Health Insurance database. The study cohort comprised 29,688 newly diagnosed adult GERD patients; 29,597 randomly selected age-, gender-, comobidity-matched subjects comprised the comparison cohort. Cox proportional hazard regressions were performed as a means of comparing the AF-free survival rate for the two cohorts. During a maximum three years of follow-up, a total of 351 patients experienced AF, including 184 (0.62%) patients in the GERD cohort and 167 (0.56%) in the control group. The log-rank test showed that patients with GERD had significantly higher incidence of AF than those without GERD (p = 0.024). After Cox proportional hazard regression model analysis, GERD was independently associated with the increased risk of AF (hazard ratio, 1.31; 95% confidence interval, 1.06–1.61, p = 0.013).ConclusionGERD was independently associated with an increased risk of future AF in a nationwide population-based cohort.

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“…Vagal overstimulation leads to bradycardia and, thus, AF. 3 (3) Inflammatory mediators, such as cytokines or interleukins, affect the cardiac conduction system. (4) The PPI itself could have an antiarrhythmic effect.…”

Section: Treatment Of Esophagitis/vagitis-induced Paroxysmal Atrial Fmentioning

confidence: 99%

Treatment of esophagitis/vagitis-induced paroxysmal atrial fibrillation by proton-pump inhibitors

Stöllberger

Finsterer

2003

Journal of Gastroenterology

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Relation of autonomic modulation to recurrence of atrial fibrillation following cardioversion

Cited by 35 publications

References 22 publications

An extremely rare presentation of supraventricular tachycardia: Burping

An extremely rare presentation of supraventricular tachycardia: Burping

Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

Treatment of esophagitis/vagitis-induced paroxysmal atrial fibrillation by proton-pump inhibitors

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