Relation of Arterial Stiffness Assessed by Brachial-Ankle Pulse Wave Velocity to Complexity of Coronary Artery Disease

Chung, Chang-Min; Yang, Teng-Yao; Lin, Yu‐Sheng; Chang, Shih-Tai; Hsiao, Ju-Feng; Pan, Kuo‐Li; Jang, Sung-Won; Hsu, Jen-Te

doi:10.1097/maj.0000000000000285

Cited by 17 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,19,21 All of these diseases are characterized by high arterial stiffness. [22][23][24] However, this may not constitute a comprehensive explanation, because our multivariable logistic regression analyses show that plasma mimecan levels are an independent predictor of baPWV.…”

Section: Discussionmentioning

confidence: 85%

“…First, high mimecan levels may be linked to arterial stiffness through a close association with CV risk factors: High serum mimecan levels have been shown to be positively correlated with CAD, hyperlipidemia, and cardiac hypertrophy . All of these diseases are characterized by high arterial stiffness . However, this may not constitute a comprehensive explanation, because our multivariable logistic regression analyses show that plasma mimecan levels are an independent predictor of baPWV.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Zhao

Zhu

et al. 2015

JAHA

View full text Add to dashboard Cite

BackgroundMimecan plays an important role in endothelial and vascular smooth muscle cell integrity and may be involved the pathology of arterial stiffness. However, the role of mimecan in arterial stiffness in patients with hypertension is not well defined.Methods and ResultsA total of 116 hypertension patients and 54 healthy controls were enrolled in the investigation. Hypertensive patients were divided into 2 groups: the with arterial stiffness group (brachial-ankle pulse wave velocity [baPWV] ≥1400 cm/s; n=83) and the without arterial stiffness group (baPWV <1400 cm/s; n=33). A noninvasive measure of vascular stiffness was performed using pulse wave velocity (PWV) measurement of baPWV. Hypertensive patients had higher baPWV, mimecan, and endothelin 1 (ET-1) than healthy controls. The arterial stiffness group had higher mimecan and endothelin 1 (ET-1) and lower ankle-brachial pressure index (ABI) than those without stiffness. In hypertensive patients, mimecan was inversely correlated with ABI (P<0.05) and positively correlated with baPWV, ET-1, and total cholesterol. On multivariable logistic regression analysis, diastolic blood pressure, mimecan, ET-1, and creatinine were independent predictors of arterial stiffness in hypertensive patients (P<0.05).ConclusionsMimecan levels are higher in hypertensive patients than in healthy controls. Increased plasma mimecan levels are independently associated with increased arterial stiffness as assessed by baPWV.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 89%

Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Zhao

Zhu

et al. 2015

JAHA

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that there is a significant inverse association between arterial stiffness and further cardiovascular disease [17–19]. A decrease in PWV is considered to correlate with improved hypertension or ideal cardiovascular health [20].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Chang

Tsai

et al. 2017

Oncotarget

View full text Add to dashboard Cite

The aim of this study was to show the effect of KCNJ5 mutational status on arterial stiffness in aldosterone-producing adenomas after adrenalectomy. Between February 2008 and January 2010, we prospectively enrolled 108 aldosterone-producing adenoma patients undergoing adrenalectomy. We conducted repeated measurements of pulse wave velocity at baseline, 6 months, and 12 months after adrenalectomy, grouped by KCNJ5 mutational status. Prognostic factors of arterial stiffness and risk for hypertension at 12 months after adrenalectomy were analyzed after propensity score matching in a 1:1 ratio. After matching for age, sex and body mass index, 88 patients were divided equally into KCNJ5-mutant and non-mutant groups. KCNJ5 mutational status was not an independent variable in either the generalized estimating equation model (p = 0.147) or the percentage change of brachial-ankle pulse wave velocity (p = 0.106). The generalized additive model smoothing plot showed that aldosterone-producing adenoma patients who carried the KCNJ5 mutation and were aged between 37 and 60 may have a hypertension recovery advantage. According to our observations during a 12-month follow-up after adrenalectomy, KCNJ5 mutational status was not associated with improvement in arterial stiffness.

show abstract

“…Stiffening of the large arteries and enhanced wave reflections lead to increased left ventricular afterload, disturbed coronary perfusion, and mechanical fatigue of the arterial wall (23). Based on these findings, the correlation between arterial stiffness and severity and complexity of CAD evaluated by the SS has been recently observed (11,12). Additionally, our study corroborated previous observational studies showing an association between arterial stiffness and severity and complexity of TAK-CAD evaluated by the SS, even when the influencing factors were controlled.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, some studies have demonstrated the correlation between arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) and the complexity of CAD as evaluated by the SS in CAD patients (11,12). Although arterial stiffness and CAD are closely related, the correlation between arterial stiffness and the complexity of CAD in TAK patients has not been examined.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Brachial–Ankle Pulse Wave Velocity in Patients With Takayasu Arteritis With Drug‐Eluting Stent Implantation

Wang

Dang

2015

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. This study investigates the long-term outcomes of drug-eluting stent (DES) implantation in patients with Takayasu arteritis (TAK). Methods. Data on 48 TAK patients and 40 age-, sex-, and severity-matched patients with coronary artery disease (CAD) receiving DES implantation and hospitalized in Fuwai Hospital from February 2004 to March 2014 were assessed. The clinical features, laboratory data, coronary angiographic findings, treatment, and followup outcomes were summarized retrospectively. Major adverse cardiac events (MACE), which include all-cause death, nonfatal myocardial infarction, and nonfatal target vessel revascularization, were recorded. Results. TAK patients exhibited increased mean 6 SD brachial-ankle pulse wave velocity (baPWV) compared with patients with CAD (17.0 6 3.8 versus 13.8 6 3.0 meters/second; P 5 0.002). However, CAD patients had higher levels of lowdensity lipoprotein cholesterol (2.5 6 1.0 versus 2.3 6 0.8 mmoles/liter; P 5 0.04). Multiple linear regression analysis revealed that baPWV was independently associated with the extent of CAD, assessed by the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) score (b 5 0.33, P 5 0.03), in TAK patients. DES implantation was deployed in 73 coronary lesions in 48 TAK patients, and restenosis occurred in 48 lesions after an average of 25.6 months (range 9.0-68.0 months) following intervention. Logistic regression analysis identified that a baPWV of 17.00 meters/second or higher (odds ratio 5.50, 95% confidence interval [95% CI] 2.1-16.6, P 5 0.008) may be considered as an independent predictor of DES restenosis. Moreover, the multivariate Cox proportional hazards model demonstrated that a baPWV of 17.00 meters/second or higher (hazard ratio 3.36, 95% CI 1.51-7.52, P 5 0.003) was significant and may serve as an independent predictor of MACE in TAK patients who underwent DES implantation. Conclusion. DES in-stent restenosis remains a challenge, affecting the long-term outcomes of patients with TAK. Measuring increased arterial stiffness through baPWV, with the addition of inflammation status monitoring during followup, would be of great clinical value to identify TAK patients with DES who have a high risk for in-stent restenosis and MACE.

show abstract

Relation of Arterial Stiffness Assessed by Brachial-Ankle Pulse Wave Velocity to Complexity of Coronary Artery Disease

Cited by 17 publications

References 36 publications

Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Arterial stiffness and blood pressure improvement in aldosterone-producing adenoma harboring KCNJ5 mutations after adrenalectomy

Prognostic Value of Brachial–Ankle Pulse Wave Velocity in Patients With Takayasu Arteritis With Drug‐Eluting Stent Implantation

Contact Info

Product

Resources

About