Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Abstract

The relation of antimullerian hormone (AMH) levels with the clinical and biochemical markers of polycystic ovary syndrome (PCOS) could be different. A total of 463 PCOS patients were evaluated in this cross-sectional study. Groups were constructed according to polycystic ovarian morphology (PCOM) and menstrual cycle-length. The relation of serum AMH with androgenic hormones, menstrual cycle-length and clinical signs of PCOS were investigated. A powerful positive relation was found between the PCOM and AMH levels (odds ratio = 2.49). There was a negative correlation between age and AMH level (p < 0.001, r[correlation coefficent] = -0.155). Positive correlations were found between luteinizing hormone (LH) and AMH (p < 0.001, r = 0.25) and also between cycle length and AMH (p < 0.01, r = 0.27). We found a negative week correlation between AMH and follicle-stimulating hormone (FSH) (p = 0.01, r = -0.19). After controlling main androgenic hormones, AMH was found to be correlated with the Ferriman-Gallway score (p = 0.03, r = 0.18). There was a positive relationship between hirsutism and AMH (odds ratio = 1.43), but no correlation between AMH and other parameters of clinical hyperandrogenism like hair-loss, acne and seborrhea were identified. The strongest relation was presented between the AMH levels and PCOM. Also, cycle-length correlated well with the AMH levels. The relationship between hirsutism and AMH is found to be independent from androgenic hormones.

The role of antimullerian hormone in the hormonal workup of women with persistent acne

“…33 Various studies have found a high sensitivity and specificity of AMH in the diagnosis of PCOS with a cutoff value ranging from 3.34 to 4.7 ng/mL. 26,29,30 In our study, 100.00% sensitivity and 95.83% specificity were seen with a cutoff value of 3.6 ( Table 4) which is similar to another study from India (3.34 ng/mL). 30 AMH has been assessed for diagnosis of PCOS with reference to the major classifications of PCOS.…”

“…It is essential to determine the cutoff points of AMH in various populations and ages as there is an age‐dependent decline in values of AMH . Various studies have found a high sensitivity and specificity of AMH in the diagnosis of PCOS with a cutoff value ranging from 3.34 to 4.7 ng/mL . In our study, 100.00% sensitivity and 95.83% specificity were seen with a cutoff value of 3.6 (Table ) which is similar to another study from India (3.34 ng/mL) …”

“…In addition, AMH is an objective, easily doable, noninvasive test, sensitive and specific in diagnosis of PCOS and gives an estimate of the ovarian reserve. [24][25][26][27][28][29][30][31][32][33] The limitations of our study are in its retrospective nature and small sample size. Future prospectively designed studies with larger populations in persistent acne patients will help in assessing the use of AMH as a tool to diagnose PCOS in acne population.…”

“…4.23.24 AMH is a simple blood test to confirm PCOS and has been studied extensively in nondermatological literature. 4,[24][25][26][27][28][29][30][31][32] Serum AMH levels are significantly higher in women with PCOS as compared to women with normal ovaries and 27 correlate with antral follicle count, ovarian volume, and severity of PCOS. Importantly, it is not affected by the adiposity, time of the cycle and has consistent age-dependent values.…”

Maximizing the clinical utility of antimüllerian hormone testing in women's health

“…As serum AMH correlates well with the polycystic appearance of ovaries on ultrasound, several studies are proposing to set thresholds by AMH as an alternative to ultrasound [44 ▪ ,46 ▪▪ ,48]. Recent evidence in 463 PCOS women suggests that serum AMH may provide insight into the subphenotypes of PCOS with higher serum AMH predicting longer menstrual cycle length, higher luteinizing hormone (LH) levels, and hirsuitism [51 ▪▪ ]. Clearly, markedly elevated age-specific AMH correlates with the clinical diagnosis and severity of PCOS and may eventually be adopted as a diagnostic criteria for PCOS.…”