Relation of Age, Sex and Infection to Reflux: Data Indicating High Spontaneous Cure Rate in Pediatric Patients

Baker, Roger; Maxted, William C.; Maylath, J; Shuman, Irwin

doi:10.1016/s0022-5347(17)63403-7

Cited by 118 publications

(44 citation statements)

References 25 publications

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“…This con clusion is consistent with the observations of Baker et al [46] who found VUR in 30% of 588 consecutive children and in 5.7% of 210 adult patients with UTI. The impor tant role of maturation of the ureterovesical junction in predisposing to VUR in the presence of UTI also pro vides some understanding of the reversibility of VUR with increasing age, and a basis for conservative, nonsurgical management of the majority of patients with VUR.…”

Section: Roberts and Riopellesupporting

confidence: 93%

Unique Consequences of Kidney Infections in Infants and Children: Pathogenesis, Early Recognition, and Prevention of Scarring

McCurdy

Vernier

1981

Am J Nephrol

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Section: Roberts and Riopellesupporting

confidence: 93%

Unique Consequences of Kidney Infections in Infants and Children: Pathogenesis, Early Recognition, and Prevention of Scarring

McCurdy

Vernier

1981

Am J Nephrol

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“…Primary reflux is thought to be more common before the age of 5 years when the incidence falls considerably, apparently by spontaneous disappearance. Barker et al [1969] reported reflux in 26.4% of children with symptomatic infection but in only 5.2% of adult parents. Primary vesico-ureteric reflux is thought to have several effects: (a) incomplete bladder emptying encourages bladder infection; (b) reflux provides an ascend ing pathway to the kidney by bacteria in the bladder, and (c) the transmission of back pressure from the bladder to the kidney might lead to renal damage.…”

Section: Discussionmentioning

confidence: 98%

Familial Renal Tract Abnormalities and Cortical Scarring

Frye

Patel

Parsons

1974

Nephron

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A family group of first and second degree relatives is presented. Members of the group have vesico-ureteric reflux and/or duplex collecting systems. Renal scars of chronic pyelonephritis are seen. It is considered that because histological features are not always specific and because the relationship of renal scars to infection uncertain, chronic pyelonephritis is a diagnosis made on radiological evidence. It is suggested that the renal scars of this condition may result from vesico-ureteric reflux in infancy. Vesico-ureteric reflux is a congenital abnormality related to the position of the junction on the bladder wall. When double ureters are present, reflux is more common. The possibility that the congenital abnormalities are inherited, is discussed. The abnormalities in the family group presented, suggest that a single gene inheritance is possible, with variable expression and occasional lack of penetrance, and no sex linkage. This genetic basis of the abnormality, suggests that anatomical and physiological disturbances underly the development of renal scarring and are worth looking for more widely in the families of those already presenting with symptoms.

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“…11,14,15,[22][23][24][25] No período de 2 a 38 anos, desaparecimento do refluxo ocorreu em 15% a 80% de crianças ou adolescentes. 9,14,16,22,[24][25][26][27][28] Em nossa casuística a porcentagem de pacientes e do número de ureteres que apresentaram resolução do RVU foi semelhante ao descrito na literatura. 15,16,[25][26][27][28] Em crianças menores de cinco anos no início do…”

Section: Discussionunclassified

“…8 O refluxo associado à infecção urinária é comum em crianças jovens; foi observado em 70% de crianças menores de um ano, 25% das menores de quatro anos, 15% das menores de 12 anos e 5% dos adultos. 9 As complicações do RVU nas crianças são episó-dios recorrentes de pielonefrite e a formação de cicatrizes renais. A avaliação pela cintilografia renal pelo dimercaptosuccinic acid (DMSA) de pacientes com RVU revelou presença de cicatrizes renais na metade dos casos; essa alta incidência pode estar associada ao atraso no diagnóstico.…”

Section: Introductionunclassified

Freqüência de desaparecimento do refluxo vésico-ureteral de graus I a III em pacientes pediátricos

Macedo¹,

Riyuzo²,

Bastos³

2004

Rev. Bras. Saude Mater. Infant.

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Objectives: to evaluate the frequency of disappearance of primary vesicoureteral reflux (VUR) grade I to III in children and correlate with patient's age at diagnosis, sex, grade and laterality.Methods: a retrospective study of 34 children with VUR detected by voiding cystourethrography (VCU). Five patients were boys (median of age: one year and six months) and 29 were girls (median of age: three years). Control exams by VCU or IC were made in performed 12 to 24 months. Kaplan-Meier survival curves were used for analysis.Results: VUR cessation was observed in 52.9% of patients. Comparing age it was not observed statistic difference. VUR cessation occurred in a median of 24 months in boys and 60 months in girls. There was statistic difference between sex (p = 0.02). VUR cessation occurred in 80% of patients with grade I (median: 25.5 months), 66.6% grade II (median: 48 months), 40% grade III (median: 60 months), in 21% of bilateral (median: 48 months) and 75% of unilateral VUR (median: 28.5 months). There was statistic difference between the grade (p = 0.02) and laterality (p = 0.05) of the VUR.Conclusions: VUR cessation occurred in grade I or II and unilateral, in boys, Key words Vesico ureteral reflux, EvoluçãoResumo Objetivos: avaliar a freqüência do desaparecimento do refluxo vésico-ureteral (RVU) primário de graus I a III em crianças e correlacionar com idade no diagnóstico, sexo, grau e lateralidade.Métodos: estudo retrospectivo de 34 crianças com RVU diagnosticado por uretrocistografia miccional (UCM). Cinco pacientes eram meninos (mediana: um ano e seis meses) e 29 meninas (mediana: três anos) O exame controle pela UCM ou cistografia foi realizado em intervalos de 12 a 24 meses. Na análise das variáveis utilizou-se a curva de sobrevida de KaplanMeier.Resultados: o desaparecimento do RVU ocorreu em 52,9% dos pacientes. Comparando faixas etárias não houve diferença estatística. Nos meninos o desaparecimento do RVU ocorreu na mediana de 24 meses e nas meninas, de 60 meses. Houve diferença estatís-tica entre os sexos (p = 0,02). Houve desaparecimento do RVU em 80% dos pacientes com RVU de grau I (mediana: 25,5 meses), 66,6% de grau II (mediana: 48 meses) 40% de grau III (mediana: 60 meses); em 21% no bilateral (mediana: 48 meses) e 75% no unilateral (mediana: 28,5 meses). Houve diferença estatística entre os graus de RVU (0,02) e lateralidade (p = 0,05).Conclusões: o desaparecimento do RVU ocorreu no sexo masculino, nos graus I ou II e unilateral. Refluxo vésico-ureteral, Evolução Palavras-chave

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Relation of Age, Sex and Infection to Reflux: Data Indicating High Spontaneous Cure Rate in Pediatric Patients

Cited by 118 publications

References 25 publications

Unique Consequences of Kidney Infections in Infants and Children: Pathogenesis, Early Recognition, and Prevention of Scarring

Unique Consequences of Kidney Infections in Infants and Children: Pathogenesis, Early Recognition, and Prevention of Scarring

Familial Renal Tract Abnormalities and Cortical Scarring

Freqüência de desaparecimento do refluxo vésico-ureteral de graus I a III em pacientes pediátricos

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