2009
DOI: 10.1021/es9000642
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Relation between Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and Human Semen Quality

Abstract: Most of the general populations are exposed to polycyclic aromatic hydrocarbons (PAHs) at different levels. A limited number of studies have suggested that PAHs exposure may be associated with semen quality. To examine the association of four PAH metabolites, 1-hydroxynapthalene (1-N), 2-hydroxynapthalene (2-N), 1-hydroxypyrene (1-OHP) and 2-hydroxyfluorene (2-OHF) with altered semen quality, 542 subjects were recruited through the clinic following strict eligibility screening. Using LC-MS/MS, individual expos… Show more

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Cited by 57 publications
(36 citation statements)
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“…[32] Urinary 1-OHP levels in our study was 14.2 and 8.3 times higher than those of the men from the study by Han et al and Xie et al [29,32] Also, the type of population for comparison such as an infertile population, coke oven workers, and the general population may contribute to the variations. [7,33] We observed that urinary 1-OHP concentration positively correlated with the levels of 16 PAH compounds in the personal breathing zone. These findings confirmed our previous study and other studies, [14,16] suggesting that urinary 1-OHP is a suitable biomarker for an initial estimate of exposure to PAHs and as estimate for biologically effective doses of PAH exposure.…”
Section: Discussionmentioning
confidence: 76%
See 1 more Smart Citation
“…[32] Urinary 1-OHP levels in our study was 14.2 and 8.3 times higher than those of the men from the study by Han et al and Xie et al [29,32] Also, the type of population for comparison such as an infertile population, coke oven workers, and the general population may contribute to the variations. [7,33] We observed that urinary 1-OHP concentration positively correlated with the levels of 16 PAH compounds in the personal breathing zone. These findings confirmed our previous study and other studies, [14,16] suggesting that urinary 1-OHP is a suitable biomarker for an initial estimate of exposure to PAHs and as estimate for biologically effective doses of PAH exposure.…”
Section: Discussionmentioning
confidence: 76%
“…[3,4] Increasing evidence showed that PAHs have had negative influence on to reproductive health and caused alteration of male sperm quality including semen quality parameters including morphology, concentration, and vitality. [5][6][7][8] PAHs are predominantly metabolized via CYP 450 enzymes and become electrophilic intermediates, such as dihydrodiol derivatives. The reactive intermediates are capable of covalently binding to DNA, potentially initiating a carcinogenic process and/or undergo redox cycling inducing an oxidative stress condition.…”
Section: Introductionmentioning
confidence: 99%
“…In the next study by the same authors i.e. , it was found that the men with higher 1-OHP (assessed as quintiles) are more likely to have below-reference sperm concentration and sperm number per ejaculum [27]. Another study found that the presence of PAH-DNA adducts in sperm is associated with abnormal morphology [25].…”
Section: Discussionmentioning
confidence: 85%
“…However, in the study by Hsu et al (2006) [28] assessing the sperm damage after exposure to polycyclic aromatic hydrocarbons the authors noticed that 1-OHP can be used as a biomarker predicting sperm dysfunction [28]. Most of the studies which examine the association between exposure to PAHs and sperm quality indicate that 1-OHP may affect male semen quality even at non-occupational exposure levels [24,25,27,41]. Also animal studies [44,45] indicate such association.…”
Section: Ijomeh 2013;26(5) 797mentioning
confidence: 99%
“…Polycyclic aromatic hydrocarbons (PAHs) are common toxic compounds generated from coal combustion during steel processing. Several PAH compounds have been reported to impair the reproductive capacity of males, including decreased semen quality in terms of concentration, motility and vitality [1][2][3]. Cellular deoxyribonucleic acid (DNA) has been suggested as a target in the subjects exposed to PAHs.…”
Section: Introductionmentioning
confidence: 99%