Relation between the severity of acanthosis nigricans and metabolic syndrome components

Kamel, Abeer M; Hassan, Marwa; Ibrahim, Mona Y.

doi:10.1097/01.ewx.0000423479.65469.67

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…This is in concordance with the studies conducted by Ayaz et al 3 and Jorwal et al 4 These abnormalities in HDL and/or TG levels can be explained by central obesity and compensatory hyperglycemia (secondary to insulin resistance). On the other hand, some other studies 5 , 8 revealed no association of AN with HDL and TG.…”

Section: Discussionmentioning

confidence: 78%

“…In our study, however, we did not find a statistically significant difference between FPG levels of AN cases and comparative groups. In some of the previous studies 3 , 5 , 8 conducted in India and other countries, a significant association of AN cases with fasting insulin and HOMA-IR was noted, but no association with FPG could be established. This could be explained by the fact that compensatory hyperinsulinemia (due to insulin resistance) in such cases is often able to maintain glucose homeostasis in the initial stages; thus, the blood glucose in these patients generally remains in the normal range and this indicates a prediabetic condition.…”

Section: Discussionmentioning

confidence: 83%

“…This is in accordance with a previous study. 8 In some other studies, AN was found to be significantly associated with either high systolic or diastolic blood pressure. 4 The relationship between AN and hypertension can be explained on the basis of insulin resistance as the common pathomechanism that is known to contribute to both conditions.…”

Section: Discussionmentioning

confidence: 89%

“…Observations from various past studies 3 , 4 , 8 have indicated that AN is associated with high BMI and waist circumference. The present study also shows similar findings.…”

Section: Discussionmentioning

confidence: 99%

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Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Choudhary¹,

Srivastava²,

Saoji³

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 89%

“…Observations from various past studies 3 , 4 , 8 have indicated that AN is associated with high BMI and waist circumference. The present study also shows similar findings.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Choudhary¹,

Srivastava²,

Saoji³

et al. 2023

Anais Brasileiros de Dermatologia

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“…Similarly, Puri 11 reported AN neck affection in (93.3%) of the included patients, followed by the axilla (66.6%) and flexural areas (40%). Moreover, Kamel et al 12 studied the link between AN and MetS and revealed that 100% of their participants had neck affection. The axilla was affected in 76.7%, but the knees, elbows, and knuckles were involved in 26.7%, 43.35%, and 30.0% of their participants, respectively.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum chemerin levels in acanthosis nigricans: A case–control study

Afify

Fathy

Elzawahry

et al. 2022

J of Cosmetic Dermatology

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Background: Acanthosis nigricans (AN) is an asymptomatic skin condition linked to several underlying systemic conditions. Chemerin is an adipokine that increases during inflammatory disorders such as metabolic syndrome (MetS). Aims:This case-control study investigates the link between AN and the underlying MetS and serum levels of chemerin in individuals with obesity.Patients/Methods: Twenty-five adults with AN and obesity (body mass index[BMI] > 30 kg/m 2 ), 25 adults with obesity but no AN, and 25 healthy controls (BMI < 30 kg/m 2 ) had their lipid profiles and serum chemerin concentrations examined. Results:The neck (80.0%) and axilla (68.0%) were the most common sites of AN. In participants with obesity, either alone or with AN, serum chemerin concentrations were significantly higher than in the control group (p < 0.001). Participants with obesity and AN had significantly higher levels of cholesterol, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and serum chemerin levels (p < 0.001), and significantly lower high-density lipoprotein cholesterol (HDL-c) levels (p < 0.001) when compared to participants with obesity alone. All participants with obesity and AN (100%) and 88% of those with obesity alone had MetS. Logistic regression revealed that systolic blood pressure >130 mmHg, diastolic blood pressure >85 mmHg, waist circumference >90 cm, TG >150 mg/dl, HDL-c <45 mg/dl, fasting blood glucose >100 mg/dl, and serum chemerin >300 ng/ml were significant (p < 0.05) risk factors for AN. Conclusions:Acanthosis nigricans is a non-invasive and reliable sign of the underlying MetS and increased serum chemerin levels among individuals with obesity.

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Therapeutic implications of dermoscopic findings in acanthosis nigricans: A clinical and histopathological study

Pardeshi

Khemani

Kamath

et al. 2020

Dermatologic Therapy

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Acanthosis nigricans is associated with numerous systemic disorders. These include endocrinological conditions such as, diabetes, acromegaly, Cushing's syndrome, thyroid dysfunction, as well as metabolic abnormalities like obesity and polycystic ovarian disease. Its association with visceral malignancy is known. Moreover, Acanthosis nigricans is known to be a cutaneous marker of insulin resistance (IR) and hyperinsulinemia. The primary aim of this study was to study clinical and histopathological patterns of acanthosis nigricans and its correlation with dermoscopic patterns and treatment implications. 103 patients clinically diagnosed as acanthosis nigricans were enrolled in the study. Clinical evaluation, dermoscopy, and skin biopsy was done for histopathological evaluation. Consistency was observed in the changes seen on dermoscopy with clinical and histopathological findings. Common dermoscopy findings were Crista Cutis, Sulcus Cutis, Papillary projections, hyperpigmented dots, crypts, and blotching Dermoscopic findings can be correlated with histopathological features. Dermoscopy allows visualization on higher magnification which helps to pick up subtle changes which are not visible to naked eye. Dermoscopy can be a useful tool to distinguish acanthosis nigricans from other pigmentary disorders in patients who are not willing for histopathological examination and helps in treatment making decisions.

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Relation between the severity of acanthosis nigricans and metabolic syndrome components

Cited by 6 publications

References 19 publications

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Association of acanthosis nigricans with metabolic syndrome – An analytic cross-sectional study

Assessment of serum chemerin levels in acanthosis nigricans: A case–control study

Therapeutic implications of dermoscopic findings in acanthosis nigricans: A clinical and histopathological study

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