Assessment of serum chemerin levels in acanthosis nigricans: A case–control study

Afify, A. A.; Fathy, Ghada; Elzawahry, Menna; Taha, Sara

doi:10.1111/jocd.15311

Cited by 3 publications

(3 citation statements)

References 24 publications

(46 reference statements)

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“…The next most common affected site was the underarm, which was seen in 80% of groups A and 60% of groups B. According to Afify et al [18] 's research, the submammary area [4%] was the least common, with the neck [80.0%] and axilla [68.0%] being the most frequent locations of AN.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between Topical Metformin 30% Cream and Topical Adapalene 0.1 % Cream in The Treatment of Acanthosis Nigricans [Clinicodermoscopic Study]

Elkhodary,

Atallah,

Aboelwafa

2023

International Journal of Medical Arts

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Article informationBackground: Acanthosis nigricans [AN] is a common cutaneous disorder with multiple etiologies. For cosmetic purposes, dermatologists usually recommend topical keratolytics, laser treatments, or chemical peels. The treatment of AN with a topical retinoid called adapalene has a high rate of success. Metformin, an insulin sensitizer, was proposed as a therapy option for AN by focusing on the insulin resistance connected to AN. Aim of the work:This study was done to compare the efficacy and safety of topical 30% metformin cream with topical 0.1 adapalene cream.Patients and Methods: There were 40 instances of AN in the most recent study. Two sets of cases, each with 20 patients, were randomly assigned: Group A [the metformin group] and Group B [the adapalene group]. The patients had a thorough dermatological examination along with a general clinical evaluation. The initial assessment included the calculation of HOMA-IR, assessment of disease severity, digital photographs, and dermoscopic assessment. After completion of treatment, clinical response and the degree of improvement were determined in the cases within the two groups. Follow-up was done for 2 months after treatment.Results: All clinical and dermoscopic results evaluated following treatment show statistically significant variance across the tested groups in terms of the degree of improvement. In the adapalene group, the extent of improvement was greater. The mean ANASI score for the metformin group decreased from 32.4 to 27.8 pre-and postoperatively, while for the adapalene group, it decreased from 26.8 to 18.4. The Adapalene group had a larger percent change, although there is no statistically significant distinction between them.Conclusion: Adapalene 0.1% cream was more successful than Metformin 30% cream in treating acanthosis nigricans with minimal and tolerable side effects. There was no difference between the two therapy regimens in terms of the chance of recurrence.

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Section: Discussionmentioning

confidence: 99%

Comparative Study between Topical Metformin 30% Cream and Topical Adapalene 0.1 % Cream in The Treatment of Acanthosis Nigricans [Clinicodermoscopic Study]

Elkhodary,

Atallah,

Aboelwafa

2023

International Journal of Medical Arts

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“…The high plasma levels of chemerin in patients may indicate the involvement of this adipokine in the pathogenesis of MetS and its role as an early VPA-MetS biomarker. Overall, clinical data indicate that circulating chemerin levels are elevated in patients with obesity, diabetes mellitus, and cardiovascular disease [57,76].…”

Section: Chemerinmentioning

confidence: 99%

Valproate-Induced Metabolic Syndrome

Shnayder,

Grechkina,

Trefilova

et al. 2023

Biomedicines

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Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.

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“…Of the patients with AN, 100% met MS criteria, suggesting that AN may serve as a non-invasive marker of MS. This would make AN an easy-to-apply clinical measure that may prove useful in addition to different blood markers of IR or associated inflammation [ 71 ].…”

Section: An and Irmentioning

confidence: 99%

Acanthosis Nigricans: Pointer of Endocrine Entities

et al. 2022

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Acanthosis nigricans (AN) has been reported in relation to insulin resistance (IR). We aim to review AN through an endocrine and metabolic perspective focusing on IR in association with metabolic complications such as obesity, diabetes mellitus (DM), and metabolic syndrome (MS) with/without polycystic ovary syndrome (PCOS). We revised English papers on PubMed covering publications from the last 5 years. The current prevalence of AN varies from 4.5 to 74% (or even 100%, depending on the studied population), with equal distribution among females and males. Despite higher incidence with an age-dependent pattern, an alarming escalation of cases has been noted for obesity and MS in younger populations . Most frequent IR-associated sites are the neck, axilla, and knuckles, but unusual locations such as the face have also been reported. Quantitative scales such as Burke have been used to describe the severity of the dermatosis, particularly in correlation with IR elements. Dermoscopic examination are required, for instance, in cases with sulcus cutis, hyperpigmented spots, crista cutis, and papillary projections. A skin biopsy may be necessary, but it is not the rule. Both IR that clinically manifests with or without obesity/MS correlates with AN; most studies are cross-sectional, with only a few longitudinal. The approach varied from screening during school periodic checkups/protocols/programs to subgroups of individuals who were already known to be at high cardio-metabolic risk. AN was associated with type2DM, as well as type 1DM. Females with PCOS may already display metabolic complications in 60–80% of cases, with AN belonging to the associated skin spectrum. AN management depends on underlying conditions, and specific dermatological therapy is not generally required, unless the patient achieves metabolic control, has severe skin lesions, or desires cosmetic improvement. In IR cases, lifestyle interventions can help, including weight control up to bariatric surgery. In addition, metformin is a key player in the field of oral medication against DM type 2, a drug whose indication is extended to PCOS and even to AN itself, outside the specific panel of glucose anomalies. In terms of cosmetic intervention, limited data have been published on melatonin, urea cream, topical retinoids, vitamin D analogs, or alexandrite laser. In conclusion, awareness of IR and its associated clinical features is essential to provide prompt recognition of underlying conditions. AN represents a useful non-invasive surrogate marker of this spectrum in both children and adults. The pivotal role of this dermatosis could massively improve endocrine and metabolic assessments.

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Assessment of serum chemerin levels in acanthosis nigricans: A case–control study

Cited by 3 publications

References 24 publications

Comparative Study between Topical Metformin 30% Cream and Topical Adapalene 0.1 % Cream in The Treatment of Acanthosis Nigricans [Clinicodermoscopic Study]

Comparative Study between Topical Metformin 30% Cream and Topical Adapalene 0.1 % Cream in The Treatment of Acanthosis Nigricans [Clinicodermoscopic Study]

Valproate-Induced Metabolic Syndrome

Acanthosis Nigricans: Pointer of Endocrine Entities

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