Relation between Red Blood Cell Distribution Width and Schizophrenia

Ayyıldız, Hakan

doi:10.14744/ijmb.2017.32042

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Although macrocytosis was not observed in the patient group, increased MCV can be considered indicative of inflammation and immune dysregulation. Consistent with our findings, studies conducted with schizophrenia and depression patients have also reported higher MCV values compared to healthy controls [ 27 , 28 ]. Further research is needed to investigate the relationship between MCV and different inflammatory markers and oxidative stress parameters in TD and other psychiatric disorders.…”

Section: Discussionsupporting

confidence: 92%

“…In the TD group, MCHC levels were significantly lower compared to the controls. In a study that investigated inflammation based on hemogram parameters, MCHC was found to be significantly lower in schizophrenia [ 27 ]. Furthermore, it has been found that low MCHC values predict depression in the long term and, in this regard, may be a better biomarker than hemoglobin [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder?

Kara,

Kul

2023

Cureus

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Objective: Tic disorder (TD) is one of the neurodevelopmental disorders and its etiology has not been fully elucidated. Complete blood count (CBC) values have been used as indicators of a systemic inflammatory response. In our study, we aimed to assess hemogram parameters in drug-naive, comorbidity-free children with TD compared with controls. Methods: This retrospective study included 62 drug-naive children with TD who had undergone CBC within one month prior to the study. A control group of 48 healthy children, matched for age and gender, without any organic or psychiatric disorders, was included. Statistical analysis was performed by using IBM SPSS Statistics for Windows, Version 22.0 (Released 2013; IBM Corp., Armonk, New York, United States). Results: Hematocrit (p = 0.044), mean corpuscular volume (p = 0.002), platelet count (p = 0.011), and plateletcrit (p = 0.031) values were significantly higher in the TD group, whereas mean corpuscular hemoglobin concentration (p = 0.00) was significantly lower in the TD group. Additionally, a significant negative correlation was observed between the duration of illness and platelet (p = 0.05, r=-0.282), plateletcrit (p = 0.038, r = -0.295), and neutrophil count (p = 0.006, r = -0.391), while a positive correlation was found between the duration of illness and eosinophil count (p = 0.018, r = 0.336). Conclusion: The results revealed several significant differences in hemogram parameters between TD patients and the control group. These may suggest the role of inflammation and/or other underlying mechanisms in TD and may inspire new studies. Future studies with larger and more homogeneous samples, including comprehensive inflammatory markers, may contribute to a deeper understanding of the relationship between inflammation and TD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder?

Kara,

Kul

2023

Cureus

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“…Significantly higher mean RDW (indicating the presence of inflammation) were found for the patients in the current results compared with controls, which agree with previous findings. 38 Significantly higher or lower mean MCH concentration and MCHC were found in the patients compared with the same in controls. Finally, significantly lower mean cholesterol and LDL concentrations, and cholesterol:HDL and LDL:HDL ratios were found for patients with SZ compared to the same for the controls.…”

Section: Discussionmentioning

confidence: 85%

Schizophrenia is linked to dyslipidemia with minimal alterations in the inflammatory biomarkers - an experience from Saudi Arabia

Alyoubi

Mahassni

2022

BioMedica

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Background and Objective: Schizophrenia (SZ) is a chronic mental illness that is associated with increased inflammation, adverse effects on the immune system, and abnormal concentrations of biochemical molecules. This study is the first to determine the concentrations of C-reactive protein (CRP) and some  proinflammatory and anti-inflammatory cytokines, the differential complete blood count (CBC), and the lipid profile in Saudi patients with SZ. Methods: Blood samples were collected from 45 randomly chosen male in-patients with chronic SZ and 29 healthy males, with an age range of 28-47 years. The concentrations of CRP, IL-6, IL-4, TNF-α, and IFN-γ; body mass index (BMI); CBC; and the lipid profile were determined through standard guidelines and compared between the patients and controls. Results: The results showed that there were no significant differences in the CRP and cytokines’ concentrations for the patients compared with those of the controls. Patients, however, had significantly higher red blood cell (RBC) distribution width. Additionally, patients had significantly lower BMI, basophil and RBC counts, basophil-lymphocyte and eosinophil-lymphocyte ratios, hemoglobin, cholesterol, and low-density lipoprotein concentrations. Conclusion: In conclusion, patients with SZ in local population showed slight inflammation and the immune system was minimally affected. Additionally, patients had dyslipidemia and were possibly more prone to anemia.

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“…Huang and Hu [43] found decreased levels of MCHC in acute myocardial infarction (AMI) and speculated that similar to RDW, MCHC can be regarded asan inflammatory marker and thus can affect the prognosis after AMI. Ayyildiz et al [41] determined higher MCH and lower MCHC in schizophrenic patients compared to healthy controls.When the literature was reviewed, only one study could be found assessing hematologic differences in schizophrenic patients after ECT. In the same study Asoglu et al [23] reported a significant increase in MCH and no difference in MCHC, MPV and RDW after repetitive ECT in 25 patients diagnosed with schizophrenia, bipolar disorder and unipolar depression.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between inflammation and anemia in some disease is well described and it has been shown that inflammation enforce both direct and indirect effects on erythropoiesis [40]. Ayyildiz et al [41] found higher RDW in 518 schizophrenic patients than healthy controls in their retrospective study and suggested that RDW might be a helpful diagnostic and prognostic marker of schizophrenia with potential utility in risk estimation and treatment monitoring. Another study with a smaller sample comparing MPV, RDW and vitamin B12 levels in schizophrenic patients and healthy controls claimed that higher RDW and MPV is associated with the inflammatory hypothesis of schizophrenia [42].…”

Section: Discussionmentioning

confidence: 99%

The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

Önen

Taymur

2020

The European Research Journal

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Objectives: In recent years there has been an increased interest on the role of inflammation in the pathophysiology of schizophrenia and a search for readily applicable prognostic markers. The impact of electroconvulsive therapy (ECT) on inflammatory function in schizophrenia is still unclear. The aim of this retrospective study is to compare pre-and post-ECT values of red cell distribution width (RDW), mean platelet volume (MPV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) which are considered to be inflammatory markers, and to discuss the findings in context of neuroinflammatory ethiology of schizophrenia. Methods: Inpatient files were reviewed via complete blood count (CBC), sociodemographic and clinical characteristics (e.g. gender, age, Body Mass Index (BMI), type of psychotropic medication). A total of 58 schizophrenic patients who underwent ECT were were compared in terms of pre-and post-ECT values of RDW, MPV, MCH, MCHC, NLR and PLR in association with type of psychotropic medication. Results: It was found that MPV, RDW, MCH and MCHC levels significantly decreased after ECT (p < 0.05), but no significant difference was found in terms of NLR and PLR (p > 0.05). When compared according to the type of psychotropic medication during ECT, MPV and MCHC were decreased after ECT in both typicaland atypical antipsychoticintervention groups (p < 0.05). ECT-related inflammatory marker changes were more likely to be associated with atypical antipsychotic medication use during ECT. Conclusions: Our results indicate that recurrent ECT sessions caused a change in the function of the immune system which might be considered to explain the therapeutic effects of ECT in schizophrenia.

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Relation between Red Blood Cell Distribution Width and Schizophrenia

Cited by 5 publications

References 16 publications

Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder?

Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder?

Schizophrenia is linked to dyslipidemia with minimal alterations in the inflammatory biomarkers - an experience from Saudi Arabia

The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

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