Relation Between Oscillatory Ventilation at Rest Before Cardiopulmonary Exercise Testing and Prognosis in Patients With Left Ventricular Dysfunction

Koike, Atsushi; Shimizu, Norifumi; Tajima, Akihiko; Aizawa, Tadanori; Fu, Long Tai; Watanabe, Hiroshi

doi:10.1378/chest.123.2.372

Cited by 22 publications

(12 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The corresponding author of a study was contacted if needed to obtain any missing information or data [9,17,[22][23][24]. If authors could not be reached [25] or if the data were no longer available, the trial was not included in this study.…”

Section: Methodsmentioning

confidence: 99%

Prognostic respiratory parameters in heart failure patients with and without exercise oscillatory ventilation — A systematic review and descriptive meta-analysis

Cornelis

Taeymans

Hens

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

The purpose of this review was to describe the occurrence of prognostic variables as derived from cardiopulmonary exercise testing (CPET) in patients with heart failure (HF), presenting exercise oscillatory ventilation (EOV) compared to patients without EOV. The effect of EOV on peak oxygen consumption (VO2), minute ventilation/carbon dioxide production (VE/VCO2) slope, oxygen uptake efficiency slope (OUES), rest and peak pulmonary end-tidal carbon dioxide pressure (PETCO2) was meta-analysed. A systematic search strategy was performed in five databases (Pubmed, Cochrane Library, PEDro, Science Direct and Web of Science) assessing 252 articles for eligibility. Nineteen citations met the inclusion criteria totalling 3032 patients with HF (EOV=1111; non-EOV=1921). The risk of bias was assessed by two researchers. Extracted data were pooled using random or fixed effects meta-analysis, if appropriate. The level of significance was set at p≤0.05. Overall, the presentation of EOV significantly indicated aggravated prognostic markers. Subgroup analysis revealed left ventricular ejection fraction (LVEF) and mode of CPET protocol as independent factors, whereas defining EOV significantly influenced the results. A meta-analysis of studies reporting hazard ratios for cardiovascular events demonstrated that HF patients with EOV run a fourfold risk for an adverse event compared to HF patients without EOV. In general, these findings suggest that the presence of EOV in patients with HF is associated with a deterioration of the prognostic CPET parameters. Furthermore, EOV can occur in HF patients with reduced as well as preserved ejection fraction. Further research on defining and assessing EOV in a more accurate and reproducible way is required.

show abstract

Section: Methodsmentioning

confidence: 99%

Prognostic respiratory parameters in heart failure patients with and without exercise oscillatory ventilation — A systematic review and descriptive meta-analysis

Cornelis

Taeymans

Hens

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…In the previous reports, the definitions were at least 2 consecutive cycles and the amplitude >25% 7 or >30%. 11 No patients with documented lung CAD, coronary artery disease; DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; LVEF, left ventricular ejection fraction; V E, ventilation; V CO2, CO2 output; V O2, O2 uptake. Oscillatory Breathing and Cardiopulmonary Function 1,347.2±1,050.9 pg/ml.…”

Section: Study Patientsmentioning

confidence: 99%

“…In our previous report, 11 we defined oscillatory breathing as at least 2 consecutive cycles and amplitude >30%. However, in the present study, we used more strict criteria (at least 3 consecutive cycles and amplitude >40%), in order to reduce the influence of physiological noise on the delicate calculation of phase difference between the V O2 and V E oscillations.…”

Section: Study Limitationsmentioning

confidence: 99%

Relation Between Oscillatory Breathing and Cardiopulmonary Function During Exercise in Cardiac Patients

Kato

Koike

Hoshimoto-Iwamoto

et al. 2013

Circ J

Self Cite

View full text Add to dashboard Cite

Cardiopulmonary exercise testing (CPX) is a useful clinical tool for evaluating the severity of disease and the limitations of activities of daily life in cardiac patients. 9 As described by the Fick's equation, O2 uptake (V O2) is the product of cardiac output and the arteriovenous O2 difference. Among the parameters obtained from CPX, the peak V O2 is traditionally considered as the gold standard for identifying patients with a poor prognosis and selecting candidates for cardiac transplantation. 10 The slope of the increase in ventilation (V E) to the increase in CO2 output (V CO2) (V E-V CO2 slope) is also an established index reflecting cardiopulmonary dysfunction during exercise. 9 scillatory breathing, alternating between hyperpnea and hypopnea during sleep and commonly referred to as central sleep apnea or Cheyne-Stokes respiration, has long been recognized in cardiac patients. An instability of the ventilatory control system, 1 long circulation time, 2-4 high sensitivity of ventilation to changes in CO2, 5 a decrease in the PaCO2 regulatory set point, 5,6 or fluctuations in the pulmonary blood flow 7,8 have been proposed as possible mechanisms underlying this abnormal breathing. A similar breathing pattern has also been recognized during waking hours in cardiac patients, especially those with heart failure. The mechanisms underlying oscillatory breathing while awake are assumed to overlap, at least in part, with those of central sleep apnea. However, reports on the mechanisms of oscillatory breathing while awake are limited. The relation between the magnitude of oscillatory breathing while awake and the severity of heart failure has not Relation Between Oscillatory Breathing and Cardiopulmonary Function During Exercise in Cardiac PatientsJo Kato, MD; Akira Koike, MD; Masayo Hoshimoto-Iwamoto, PhD; Osamu Nagayama, BSc; Koji Sakurada; Akira Sato, MD; Takeshi Yamashita, MD; Karlman Wasserman, MD, PhD; Kazutaka Aonuma, MD Background: Oscillatory breathing, alternating between hyperpnea and hypopnea, has been recognized in cardiac patients, especially in those with heart failure. We evaluated whether the cycle length and amplitude of oscillatory breathing correlate with impaired cardiopulmonary function during exercise.

show abstract

“…These patients usually present a reduction in the central and peripheral blood flow during exercise, since the increased peripheral vascular conduction is strongly associated to cardiac output response. Thus, after the AMI, the changes in ventricular function that compromise cardiac output may be responsible for the decline in aerobic functional capacity of these patients [35][36][37] . Therefore, the lowest values of VO 2 found in the AMIG, both in the AT and in the peak of the sub-maximal CPET, may be attributed to reduced cardiac output and increased peripheral vascular conductance.…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary exercise testing in the early-phase of myocardial infarction

Kunz

Serra

Borges

et al. 2012

Rev. bras. fisioter.

View full text Add to dashboard Cite

Objective: To evaluate and to compare the cardiorespiratory and metabolic variables at the ventilatory anaerobic threshold level (AT) and at submaximal cardiopulmonary exercise testing (CPET) in both, healthy volunteers and in patients in the early phase after acute myocardial infarction (AMI). Method: Twenty-six volunteers underwent a submaximal or symptom-limited cardiopulmonary exercise testing (CPET) on a cycle ergometer and were divided into AMI group (AMIG=12, 56.33±8.65 years) and healthy group (CG=14, 53.33±3.28 years). The primary outcome measures were the cardiorespiratory and metabolic variables obtained at the peak workload and at the AT of the CPET. precocemente para a avaliação cardiorrespiratória por apresentar alta sensibilidade para detectar alterações de forma segura.Palavras-chave: consumo de oxigênio; infarto do miocárdio; exercício físico; fisioterapia.

show abstract

Relation Between Oscillatory Ventilation at Rest Before Cardiopulmonary Exercise Testing and Prognosis in Patients With Left Ventricular Dysfunction

Cited by 22 publications

References 40 publications

Prognostic respiratory parameters in heart failure patients with and without exercise oscillatory ventilation — A systematic review and descriptive meta-analysis

Prognostic respiratory parameters in heart failure patients with and without exercise oscillatory ventilation — A systematic review and descriptive meta-analysis

Relation Between Oscillatory Breathing and Cardiopulmonary Function During Exercise in Cardiac Patients

Cardiopulmonary exercise testing in the early-phase of myocardial infarction

Contact Info

Product

Resources

About