Relation between lymphatic vessel diameter and clinicopathologic parameters in squamous cell carcinomas of the oral region

Nakayama, Atsushi; Ogawa, Atsushi; Fukuta, Yoshiyasu; Kudo, Keigo

doi:10.1002/(sici)1097-0142(19990715)86:2<200::aid-cncr3>3.0.co;2-#

Cited by 21 publications

(13 citation statements)

References 27 publications

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“…[3233] However, in this study it was 30.0%. In cases of oral squamous cell carcinoma, metastasis in the cervical lymph nodes may occur even in T1 or T2 cases of primary tumor.…”

Section: Discussionmentioning

confidence: 58%

A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis

Akhter

Hossain

Rahman

et al. 2011

J Oral Maxillofac Pathol

117

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Background:Histological grading is an important diagnostic tool to predict the clinical and biological behaviour of cancer. Cervical lymph node metastasis indicate poor prognosis of oral cancer. Considering economical status of a third world country, Anneroth's grading system is less expensive, more informative than TNM staging and Broder's grading system. Anneroth's grading system also shows co-relationship with lymph node metastasis. So we are trying to evaluate the Anneroth's grading as a standard one among these three system.Objective:To study the grading of histological malignancy according to Anneroth's classification of biopsy specimens in relation to metastasis in the cervical lymph nodes and comparing the Anneroth's with the other two recognized classifications.Materials and Methods:Fifty(50) patients with oral squamous cell carcinoma was included in the study. Specimen of 35 non-metastatic tumors were compared with 15 metastatic cases. All of the patients were graded to TNM, Broder's and Anneroth's system. TNM is clinical assessment and Broder's is based on only differentiation of cells. On the other hand, six parameters of Anneroth's gives a detail about the morphology of the tumor, invasion criteria in the host tissue and show its correlation with lymph node metastasis. Scoring system of Annearoth's grading indicates demarcation points of worseness of tumor and signifies the possibility of lymph node metastasis.Results:Both Anneroth's(P=0.002) and Broder's grading(P=0.012) have been significant but Anneroth's one is more significant then Broder's.Conclusion:Anneroth's classification can be taken as a standerd diagnostic factor and predictive factor of lymph node metastasis.

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“…[3233] However, in this study it was 30.0%. In cases of oral squamous cell carcinoma, metastasis in the cervical lymph nodes may occur even in T1 or T2 cases of primary tumor.…”

Section: Discussionmentioning

confidence: 58%

A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis

Akhter

Hossain

Rahman

et al. 2011

J Oral Maxillofac Pathol

117

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“…(18) Several reports have shown that unlike lympha-tic vessels in normal tissue, the average diameter and density of lymphatic vessels (LVD) in OTSCC significantly increased, and statistical analysis demonstrated that higher LVD had a close association with an increased risk of lymphatic dissemination. (6,19,20) Additionally, inhibition of lymphangiogenesisrelated properties of LECs would reduce the risk of lymph node metastasis of cancer cells. (21) These results indicated that cancer-induced lymphangiogenesis may be essential for secondary lymphatic spread.…”

Section: Discussionmentioning

confidence: 99%

Altered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells

Zhang

Pan

et al. 2010

Cancer Science

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The lymphatic endothelial cell (LEC) is an interactive surface for cancer cells. This article aims to explore cancer cell-induced changes of LEC, and study the tumor-lymphatic endothelium interaction. Here, LECs were co-cultured with highly and poorly metastatic tongue cancer cells. The differences in biologic behaviors and gene expression profiles between them were examined. The results showed that LECs induced by highly metastatic cancer cells displayed abnormal biologic behaviors, and could secrete chemokines to promote the migration of cancer cells. Therefore, biologic properties and functional status of LECs in oral tongue squamous cell carcinoma (OTSCC) might be a positive factor in lymphatic dissemination. (Cancer Sci 2010; 101: 686-692) T he lymphatic system plays multiple roles in biologic processes, such as tissue homeostasis, supplemental circulation, and immune surveillance.(1,2) However, lymphatic vessels also act as conduits for metastatic tumor cells to escape from the primary tumor in most carcinomas.(3) Lymphatic spread is much more important in oral tongue squamous cell carcinoma (OTS-CC) than in other cancers, because they preferentially metastasize to roughly 400 lymph nodes in the cervical region, and lymph node metastasis is the strongest prognostic factor for survival of OTSCC patients. (4,5) Until now, the details of the process and molecular mechanisms of lymphatic metastasis have been unclear. Several reports on OTSCC showed that intratumoral and peritumoral lymphatic vessels were closely related to lymphatic metastasis, for they provided additional conduits for the dissemination of cancer cells. (6)(7)(8) Although lymphatic vessels constitute the most important channel of lymphatic spread, the lymphatic endothelium provides an interactive surface for cancer cells, and the ability of cancer cells to interact with the lymphatic endothelial cells (LECs) is a key step in their invasion of the lymphatic system. Recent studies demonstrated that tumor-derived LECs had a remarkable degree of phenotypic plasticity.(9) Our previous study also showed that oral tongue cancer-induced LECs were more proliferative and had enhanced ability to organize capillary-like structures.(10) However, it is unclear whether altered LEC properties are consequences of the increased metastatic potential of tongue cancer cells, and whether these specific phenotypes contribute to the lymphatic dissemination of OTSCC.Tca8113 and LNMTca8113 cells had different potential of metastasis via lymphatic vessels. It was previously demonstrated that lymphangiogenesis in tumors derived from LNMTca8113 cells was promoted compared with that from Tca8113 cells. Moreover, it was confirmed that the number of micro-lymphatic branches in LNMTca8113 conditioned medium (CM) increased more rapidly than that in Tca8113 CM when induced lymphangioma were cultured in tumor conditioned medium (TCM) (accepted by Journal of West China Stamotology).In order to explore cancer cell-induced changes of LEC, and study the tumor-lymphatic endotheliu...

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“…In addition, Nakayama et al. demonstrated that the larger diameter of lymphatic vessels correlated significantly with the mode of invasion (6). By using a double staining and not an immunohistochemical method, they found no correlation between T‐classification and histological differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…In commonly used haematoxylin staining, lymphatic vessels are often not clearly distinguishable from capillaries and post‐capillary venules. We are aware of one study that correlated the diameter of lymphatic vessels in squamous cell cancer of the oral cavity with T‐classification, tumour grading and mode of invasion (6). Most recently, a high intratumoural lymphatic vessel density (LVD) was found to be associated with cervical lymph node metastasis by using the endothelial marker LYVE‐1 (7).…”

mentioning

confidence: 99%

Expression of vascular endothelial growth factor‐C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer

Sedivy

Beck-Mannagetta

Haverkampf

et al. 2003

J Oral Pathology Medicine

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Relation between lymphatic vessel diameter and clinicopathologic parameters in squamous cell carcinomas of the oral region

Cited by 21 publications

References 27 publications

A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis

A study on histological grading of oral squamous cell carcinoma and its co-relationship with regional metastasis

Altered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells

Expression of vascular endothelial growth factor‐C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer

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