Relation Between Lipoprotein(a), Fibrinogen and Intima-Media Thickness in Hypertensive Patients: PP.23.452

Şerban, Corina; Noveanu, Lavinia; Susan, L.; Pacurari, A.; Caraba, Alexandru; Costea, Camelia; Mateescu, Rodica; Romoşan, I; Cristescu, A

doi:10.1097/01.hjh.0000379378.72016.e9

Cited by 3 publications

(2 citation statements)

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“…1,2 Individuals with hypertension often exhibit abdominal obesity, decreased high density lipoproteincholesterol (HDL-C), hyperglycemia and hyperlipidemia, [3][4][5][6] all of which may contribute to the onset of cardiovascular disease. Because it exerts multiple harmful effects on the human body without showing any symptoms, hypertension is known as a ''silent killer'' and presents a public health concern in modern society.…”

Section: Introductionmentioning

confidence: 99%

Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Kong

et al. 2011

Mol. BioSyst.

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Hypertension is a key risk factor in the progression of cardiovascular disease (CVD). Dyslipidemia, a strong predictor of CVD, frequently coexists with hypertension. Therefore, the control of hypertension and dyslipidemia may help reduce CVD morbidity and mortality. In the present study, the therapeutic effects of antihypertensive agents on blood pressure control and plasma lipid metabolism were evaluated. The plasma lipid profiles of patients with treated (n = 25) or untreated (n = 30) essential hypertension as well as of subjects with normotension (n = 28) were analyzed using liquid chromatography mass spectrometry. Principal component analysis of the lipidomics data revealed distinct clusters among studied subjects across three human populations. Phosphatidylcholines and triacylglycerols (TG) dominated the pattern of hypertension-influenced plasma lipid metabolism. Discriminatory lipid metabolites were analyzed using one-way analysis of variance followed by a post hoc multiple comparison correction. TG lipid class was significantly increased by 49.0% (p o 0.001) in hypertensive vs. normotensive groups while tended to decrease (À21.2%, p = 0.054) in hypertensive patients after treatment. Total cholesteryl esters were significantly decreased by À16.9% (p o 0.001) in hypertensive patients after treatment. In particular, a large number of individual neutral lipid species were significantly elevated in hypertensive subjects but significantly decreased after treatment with antihypertensive agents. The present study applied, for the first time, a systems biology based lipidomics approach to investigate differentiation among plasma lipid metabolism of patients with treated/untreated essential hypertension and subjects with normotension. Our results demonstrate that antihypertensive medications to lower blood pressure of hypertensive patients to target levels produced moderate plasma lipid metabolism improvement of patients with hypertension.

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Section: Introductionmentioning

confidence: 99%

Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Kong

et al. 2011

Mol. BioSyst.

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“…Serban et al found that the levels of Apo B reflected the atherogenic lipids and suggested that Apo B level is a quantitative index of plasma atherogenic lipids in hypertensive patients who presented with dyslipidemia [18]. The postprandial levels of ApoB100 are significantly altered than the corresponding values of fasting levels in both genders.…”

Section: Resultsmentioning

confidence: 99%

Correlation Between the Estimated and the Measured Serum Apolipoprotein –B100 in Kurd Subjects: A Trend to Establish a New Formula

Sami

Hussein

Saeed

et al. 2023

Al-Mustansiriyah Journal of Science

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Apolipoprotein B100 (ApoB100) provides a good assessment of atherogenic lipoproteins (very low, intermediate, and low-density lipoproteins (VLDL, IDL, and LDL)). There is evidence that polymorphism of ApoB100 was observed in many conditions and it links with obesity, diabetes mellitus hypertension, and chronic inflammation, which could be related to the broad field of the atherothrombotic process, and could be one of the leading causes of coronary artery disease (CAD). It can be computed using a formula that makes use of a measurement of non-high-density lipoprotein levels. This study aimed to derive an estimated equation of ApoB100 from the measured ApoB100 levels specific to the healthy subjects of Kurd race/ethnicity in the Kurdistan region of Iraq taking into consideration the gender-based effect and the status of fasting and postprandial effects. A total number of 45 healthy subjects (23 males and 22 females) were enrolled in the study. The following measurements were achieved: anthropometric indices, blood pressure, lipid profile, including ApoB100, and blood sugar. The biochemical measurements were carried out at fasting and postprandial states. Specific equations were derived for calculating the levels of ApoB100. Significant differences in the anthropometric indices, blood pressure, and lipid profile were observed between males and females. The calculated ApoB100 levels were significantly less than the measured ApoB100 levels in both genders and fasting and postprandial states. The estimated equations for ApoB100 for females have differed from that for males at fasting and postprandial states. The levels of ApoB100 can be determined instead of measuring it in the laboratory by using a specific equation for healthy Kurd people. These equations are gender and race/ethnicity based. The established equation of estimated ApoB100 levels in males differed from that in females which is attributed to the cardio-metabolic factors and higher levels of systolic and mean arterial blood pressures among males. Apo B level is a quantitative index of plasma atherogenic lipids in hypertensive patients who presented with dyslipidemia.

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Fragmented QRS complex, highly sensitive CRP, and fibrinogen in early detection of asymptomatic cardiac involvement in systemic lupus erythematosus

Kamal,

Fahmi,

Abdelsalam

et al. 2023

Egypt Rheumatol Rehabil

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Background Patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular illnesses. Asymptomatic affection might exist, so early diagnosis can improve the outcome. Aim The purpose of this study was to determine the importance of highly sensitive C-reactive protein, fragmented QRS, and fibrinogen levels in identifying subclinical cardiac involvement in SLE patients, as well as how these variables relate to disease activity. Results Regarding hs-CRP and fibrinogen, there were significant differences between the SLE and control group, with a higher frequency of fQRS in the lupus group. The lupus group was divided into 2 subgroups: 44 patients with fragmented QRS in ECG (83%) and 9 patients with normal QRS (17%) with a higher mean value of hs-CRP and fibrinogen level (58.76 ± 70.15, 18.54 ± 26.79) and low HDL (53.37 ± 10.37) in those with fQRS ( +). The sensitivity and specificity of hs-CRP at a cut of level (3.5 mg/L) for fQRS in SLE patients were 75.5%, and 71.7%, respectively. Regression analysis showed hs-CRP and were significant predictors for fQRS changes in SLE patients. Conclusions A more thorough evaluation of SLE patients with fQRS complexes with hs-CRP and fibrinogen is important with close follow-up for the detection of subclinical cardiac involvement in SLE. Also, SLE activity is linked to fQRS and fibrinogen. Therefore, we advise using them for additional medical care for lupus.

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Relation Between Lipoprotein(a), Fibrinogen and Intima-Media Thickness in Hypertensive Patients: PP.23.452

Cited by 3 publications

References 0 publications

Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Correlation Between the Estimated and the Measured Serum Apolipoprotein –B100 in Kurd Subjects: A Trend to Establish a New Formula

Fragmented QRS complex, highly sensitive CRP, and fibrinogen in early detection of asymptomatic cardiac involvement in systemic lupus erythematosus

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