Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Hu, Chunxiu; Kong, Hongwei; Qu, Fengxue; Li, Yong; Yu, Zhen-Qiu; Gao, Peng; Peng, Shuangqing; Xu, Guowang

doi:10.1039/c1mb05342f

Cited by 57 publications

(49 citation statements)

References 41 publications

(62 reference statements)

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“…187 Application of lipidomics to human plasma has direct utility, with potential to identify novel and predictive biomarkers of disease, [188][189][190][191] including coronary disease progression, 192,193 as well as biomarkers of responsiveness to therapeutic intervention. 194,195 As many specific lipid species are being generated in vivo from dietary precursors, lipidomics is a promising avenue for understanding the complex relationship between dietary lipids and cardiometabolic risk and identifying lipid biomarkers of dietary intake.…”

Section: Lipidomicsmentioning

confidence: 99%

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Ferguson¹,

Allayee²,

Gerszten³

et al. 2016

Circ Cardiovasc Genet

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Abstract-Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention. The interpretation and scope of nutrigenomics may vary, but it can be thought to encompass the spectrum of nutritional genomics research, including classic nutrigenetics studies of gene-diet interactions and molecular nutrition, in vitro and in vivo models, human nutrition studies, and the application of largescale, unbiased studies using high-throughput "omics" techniques to study the effects of nutrients on the body. 6 As the Figure shows, diet and the genome may influence cardiometabolic health through a variety of interconnected intermediates, perturbations in which can be measured through omics technologies, including RNA expression (transcriptome), epigenetic modifications (epigenome), metabolites (metabolome), lipids (lipidome), proteins (proteome), and resident microbial communities (microbiome). Although it is clear that both nutrients and genes play a distinct role in determining health, the complex interactions among genes, diet, and downstream networks are not well understood. The application of nutrigenomics approaches to questions of human health and disease is an important component in understanding the complexities of the interplay between basic metabolic processes and externalThe American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 22, 2016, and the American Heart Association Executive Committee on February 23, 2016. A copy of the document is available at http://professional.heart.org/statements by using either "Search for Guidelines & Statements" or the "Browse by Topic" area. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@ wolterskluwer.com.The...

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Section: Lipidomicsmentioning

confidence: 99%

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Ferguson¹,

Allayee²,

Gerszten³

et al. 2016

Circ Cardiovasc Genet

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“…It was shown recently that total PC and TG are elevated in hypertensive patients and that antihypertensive agents reduce plasma total cholesteryl esters and TG [11]. Obesity leads to increased lipid load in plasma, while IR controlled for body mass index (BMI) has little effects on plasma lipid composition.…”

Section: Introductionmentioning

confidence: 99%

Glycerophospholipid and Sphingolipid Species and Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

Sigrüener¹,

Kleber

Heimerl³

et al. 2014

PLoS ONE

133

110

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Vascular and metabolic diseases cause half of total mortality in Europe. New prognostic markers would provide a valuable tool to improve outcome. First evidence supports the usefulness of plasma lipid species as easily accessible markers for certain diseases. Here we analyzed association of plasma lipid species with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Plasma lipid species were quantified by electrospray ionization tandem mass spectrometry and Cox proportional hazards regression was applied to assess their association with total and cardiovascular mortality. Overall no differences were detected between total and cardiovascular mortality. Highly polyunsaturated phosphatidylcholine species together with lysophosphatidylcholine species and long chain saturated sphingomyelin and ceramide species seem to be associated with a protective effect. The predominantly circulating phosphatidylcholine-based as well as phosphatidylethanolamine-based ether species and phosphatidylethanolamine species were positively associated with total and cardiovascular mortality. Saturated and monounsaturated phosphatidylcholine species, especially phosphatidylcholine 32∶0 (most probably dipalmitoyl-phosphatidylcholine) and palmitate containing sphingomyelin and ceramide species showed together with 24∶1 containing sphingomyelin and ceramide species strongest positive association with mortality. A quotient of the sums of the six most protective species and the six species with the strongest positive mortality association indicated an almost 3-fold increased risk of mortality, which was higher than the hazard ratio for known risk factors in our cohort. Plasma lipid species levels and especially ratios of certain species may be valuable prognostic marker for cardiovascular and total mortality.

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“…Lipid profiling has shown promising results in diabetes mellitus, [41][42][43][44][45][46][47] CVDs, 35,37,38,48-52 metabolic disorders, 40,53,54 dietary habits, and obesity, 47,49,[55][56][57][58][59][60][61] as well as in determining response to drug therapy. [62][63][64][65] Most studies analyzed either blood or tissue samples (ie, diabetic retinopathy, 46 atherosclerotic plaques, 52 muscle, 47 or adipose tissue). 58,59 Predominant methods of choice are LC-MS/MS and shotgun lipidomics.…”

Section: Applications Of Lipidomics To Clinical Cohortsmentioning

confidence: 99%

“…The effect of drugs, such as of antihypertensive agents, 62 recombinant HDL infusion, 63 and statins, 64,65 on lipid profiles has also been assessed. Other important biomarker studies include oxidation of PUFA.…”

Section: Applications Of Lipidomics To Clinical Cohortsmentioning

confidence: 99%

Lipidomics

Hinterwirth

Stegemann

Mayr

2014

Circ Cardiovasc Genet

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Abstract-Lipidomics is the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The huge diversity of native lipids and their modifications make lipidomic analyses challenging. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography. Although shotgun lipidomics allows for high-throughput analysis, low-abundant lipid species are not detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. In this review, we will discuss the potential of lipidomics for cardiovascular research. To date, cardiovascular research predominantly focuses on the role of lipid classes rather than molecular entities. An in-depth knowledge about the molecular lipid species that contribute to the pathophysiology of cardiovascular diseases may provide better biomarkers and novel therapeutic targets for cardiovascular disease. (Circ Cardiovasc Genet. 2014;7:941-954.)

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Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy

Cited by 57 publications

References 41 publications

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment

Glycerophospholipid and Sphingolipid Species and Mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

Lipidomics

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