Relation between<i>Helicobacter pylori</i>infection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in Egypt

Elkhouly, Nabih I; Elkelani, Osama; Elhalaby, Alaa F; Shabana, Ayman

doi:10.1080/01443615.2016.1196169

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…The primary outcomes we focused on were preeclampsia and fetal growth restriction. Sixteen studies with a total of 10 402 women reported the influence of H pylori infection on the risk of preeclampsia. Pooled results suggested an OR of 2.51 (95% CI: 1.88‐3.34; P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

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The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

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Objective To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. Materials and Methods A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed. Results Thirty‐one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88‐3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21‐4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56‐2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05‐2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05‐2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03). Conclusion The present meta‐analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.

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Section: Resultsmentioning

confidence: 99%

“…,26,27,29,[37][38][39][40][42][43][44][46][47][48][49][50] with a total of 10 402 women reported the influence of H pylori infection on the risk of preeclampsia. Pooled results suggested an OR of 2.51 (95% CI: 1.88-3.34; P < 0.001).…”

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confidence: 99%

The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

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“…Then, Mubarak et al (34) detected a high prevalence of Hp infection among pregnant women in Khartoum. Thereafter, Mosbah & Nabiel (35) found the prevalence of Hp infection in PE pregnant women, was 54.4% with statistically significant association to PE and Elkhouly et al (36) reported significantly higher percentage of HPSA positive women among PE cases especially those complicated by IUGR compared to healthy pregnancies (76% vs. 32%) and concluded that Hp infection has a possible role in etiopathogenesis of PE with IUGR.…”

Section: Discussionmentioning

confidence: 99%

Obesity, Helicobacter pylori Infection and Preeclampsia: A triangle of Danger for pregnant women Running title: Helicobacter pylori Infection and Preeclampsia.

Shedid¹,

Mourad

2018

The Egypt. J. of Fert.y of Steri.

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Objectives:To determine the frequency of Helicobacter pylori (Hp) infection among primigravida and its relation to development of preeclampsia (PE). Patients and Methods:This cohort study included 146 primigravida evaluated prior to the 12th week gestational age, women who developed PE were categorized as PE group and a similar number of pregnant women free of hypertensive manifestations as control (No PE) group. All patients were evaluated for age and body mass index (BMI) and underwent Hp diagnosis workup including Urea breath test and Hp stool antigen testing.Results: Twenty-six women developed early and 47 developed late PE and 52 had mild, while 21 had severe PE. Development and severity of PE showed positive significant correlation with BMI. Sixty patients were Hp+; blood pressure measures at time of development of PE were significantly higher in Hp+ than in Hp-patients, irrespective of developing PE. Blood pressure measures and BMI showed positive significant correlation with Hp positivity. Statistical analysis defined high BMI as the significant independent predictor for development of PE. Conclusion:High BMI may underlie the development and severity of PE and is associated with Hp infection.

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“…Moreover, a separate case-control study revealed that a significantly higher percentage of women positive for H. pylori stool antigen (HPSA) (indicative of H. pylori infection) developed preeclampsia (PE) with intrauterine growth restriction (IUGR) compared with HPSA-negative women. It is thought that H. pylori-inducediron deficiency anemia (IDA) plays a role in driving IUGR as well [13,14]. These results thus indicated possible etiopathological connections between maternal H. pylori infection and IUGR.…”

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confidence: 88%

Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

Lai

Sheu

et al. 2019

Preprint

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Background: Helicobacter pylori infection is known to alter growth-related hormones and cause growth faltering in young children. It is still unknown if maternal H. pylori infection has an impact on the levels of cord blood growth-related hormones and can predict intrauterine growth restriction and poor physical and neurodevelopmental outcomes in children. This study aimed to examine the associations between maternal H. pylori infection and pregnancy-related adverse events, fetal growth and early childhood development. Methods: The prospective cohort study recruited singleton pregnant women without major medical illnesses from January 2014 to January 2015. Seropositivity for H. pylori was defined by >12 U/ml of anti- H. pylori IgG in the maternal serum. Demographic data and pregnancy-related medical issues of the cohort were documented. Cord blood levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), insulin, and ghrelin were determined using ELISA test. The growth of eligible neonates was monitored annually for up to 3 years, and cognitive development was assessed using the comprehensive developmental inventory for infants and toddlers (CDIIT) test 3 years after birth. Results: Of the 106 enrolled women, 25 (23.6%) were H. pylori -seropositive. Maternal H. pylori seropositivity was correlated with a higher risk of developing gestational hypertension (GH) (12% vs. 1.2%, p =0.04) and lower cord blood levels of IGF-1 (<35 ng/ml, 70.0% vs. 40.7%, p =0.02) and IGFBP-3 (<1120 ng/ml, 100.0% vs. 76.3%, p =0.02) compared with the seronegative women. No significant impact on birth weight, childhood growth and cognitive development was found to correlate with maternal H. pylori seropositivity during pregnancy. Conclusions: Maternal H. pylori infection during pregnancy was more likely to develop GH, but not correlated with fetal and childhood growth and development. In addition to close monitoring of hypertension, H. pylori eradication can be considered for such H. pylori -infected mothers.

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Relation betweenHelicobacter pyloriinfection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in Egypt

Cited by 11 publications

References 19 publications

The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta‐analysis

The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Obesity, Helicobacter pylori Infection and Preeclampsia: A triangle of Danger for pregnant women Running title: Helicobacter pylori Infection and Preeclampsia.

Maternal H. pylori seropositivity is associated with gestational hypertension but irrelevant to fetal growth and development in early childhood

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