Relation Between Human T-Lymphotropic Virus Type I and Neurologic Diseases in Panama: 1985-1990

Gracia, Fernando; Castillo, Luís; Larreategui, Mario; Roberts, Brian R.; Cedeño, Victor; Heneine, Walid; Blattner, William; Kaplan, Jonathan E.; Levine, Paul H.

doi:10.1097/00042560-199510020-00013

Cited by 7 publications

(4 citation statements)

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“…High prevalence of 8.3-9% has also been reported among indigenous populations of Panama, all carrying HTLV-2. Although multiple cases of TSP/HAM have been reported, mostly associated with HTLV-1 infection [349][350][351][352][353], only five ATLL cases have been reported in Central American countries, one associated with HTLV-1 infection and the others of an unknown etiology [230,231,234].…”

Section: Htlv Prevalence and Morbidity In Latin Americamentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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Section: Htlv Prevalence and Morbidity In Latin Americamentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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“…In Panama, the first cases of MS were reported in the 1980s, during studies carried out on human T-cell lymphotropic virus [10][11][12] . The prevalence was considered low, but there were no additional studies to confirm this observation.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Incidence of Multiple Sclerosis in Panama (2000–2005)

Gracia

Castillo²,

Benzadón³

et al. 2009

Neuroepidemiology

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Background: The first cases of multiple sclerosis (MS) in Panama were notified in the 1980s and it was considered a low-risk region for this disease. Between 2000 and 2005, a prevalence study was conducted to characterize MS in Panama. Methods: An instrument was developed to gather information from clinical files and interviews with previous informed consent. The diagnosis was confirmed by neurologists applying the Poser and McDonald criteria as per the inclusion period. Results: 178 patients from the public and private health sectors were captured between 1970 and 2005. The prevalence rate was 5.24/100,000 inhabitants, and the incidence was between 0.28 and 0.61/100,000 inhabitants. The disease was predominant among women, the mean age ± SD being 34.76 ± 10.909 years (1st crisis), and the average number of crises was 2.88. The most common clinical findings were motor, optic neuritis, sensitive and cerebellous. 52.4% presented monosymptomatic manifestations, 71.6% were clinically defined according to Poser’s criteria and 55.6% had MS according to McDonald’s criteria. 77.8% had their debut with the relapsing-remitting type and presented an Expanded Disability Status Scale score of 2.7 after the first crisis. Conclusion: MS is in Panama a neurological pathology with a low prevalence and the results of this investigation improved early treatment and diagnosis of this disease.

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“…Los africanos que llegaron a poblar principalmente el Caribe, Centroamérica y Brasil durante los siglos XVI y XVII trajeron consigo las cepas africanas del HTLV-I. 9,12,13 .…”

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Paraparesia espástica progresiva asociada a HTLV-I en Chile: Estudio y seguimiento de 121 pacientes por diez años

2009

Rev. chil. neuro-psiquiatr.

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Revision is made to 121 Chilean patients with progressive adult spastic paraparesis (PSPs) associated to HTLV-I. Epidemiologic, clinical, diagnosis and associated illnesses aspects are analyzed as well as the pathogenesis. The follow-up of patients during several years allowed defining the evolutional profile, establishing the causes of death and studying the virus' behavior. Pathogenetic hypothesis arose from the neuropathological search to define the mechanisms of damage supported on immunohystochemical studies. It was confirmed that the CNS illness is a degenerative process linked to a central axonopathy which expresses flaws in the axoplasmic transport, particularly affecting the corticospinal tracts, although there is a more extended myeloencephalic involvement. Furthermore, the virus is capable of producing a multisystemic illness that may simultaneously involve the nervous system; the haemathological system; the exocrine glands; the hepatic, lung, muscular and bone parenchymas. ARTÍCULO DE REVISIÓNH eran portadores de una paraparesia espástica progresiva 3 .Los estudios epidemiológicos del virus, realizados en Chile en la década del 90, observaron una seroprevalencia de 0,70%, en la población chilena general 4,5 y una seroprevalencia mayor, del 1% al 9% entre los "pueblos originarios" que sugerían una presencia prehispánica del HTLV-I en Chile y en América 6,7 .Presuntamente, este retrovirus habría sido REV CHIL NEURO-PSIQUIAT 2009; 47 (1): 50-66

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Relation Between Human T-Lymphotropic Virus Type I and Neurologic Diseases in Panama: 1985-1990

Cited by 7 publications

References 0 publications

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Prevalence and Incidence of Multiple Sclerosis in Panama (2000–2005)

Paraparesia espástica progresiva asociada a HTLV-I en Chile: Estudio y seguimiento de 121 pacientes por diez años

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