Abstract:PurposeUveal Melanoma is a rare ocular malignancy; high‐risk monosomy 3 tumors often show an increased density of tumor‐infiltrating lymphocytes and macrophages. Histone deacetylases (HDACs) are a group of epigenetic modifiers, some of which are increased in monosomy 3 UM. We compared HDAC expression in Uveal Melanoma (UM) with the presence of infiltrating leukocytes. We furthermore determined whether expression was modifiable by interferon‐gamma.MethodsThe expression of nine HDACs and CD3E, CD8 and CD68 leuko… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.