Relation between high Ankle-Brachial Index and cardiovascular outcomes in the general population and cardiovascular disease: a meta-analysis

Yang, Yu; Liu, Longguang; Sun, Hongxiao; Nie, Fengze; Hu, Xinhua

doi:10.23736/s0392-9590.19.04276-7

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…Prior studies of community populations have shown independent associations of high ABPI with cardiovascular events in some but not all populations [3,5,[7][8][9][10][12][13][14]. In the current study participants were recruited from hospital out-patient clinics and had PAD diagnosed by a vascular specialist.…”

Section: Discussionmentioning

confidence: 99%

“…ABPI which allowed comparison with that high risk group, unlike prior studies which have simply compared to people with normal ABPI [3,5,[7][8][9][10][12][13][14]. Within this PAD population, high ABPI strongly and independently predicted the key clinical events of MACE, MI and death.…”

Section: Plos Onementioning

confidence: 97%

“…Since high ABPI indicates arterial calcification, an established predictor of cardiovascular events, it is likely that its identification has important implications for prognosis and treatment [11]. In previous studies high ABPI has been associated with increased risk of cardiovascular events in some but not all studies [3,[7][8][9][12][13][14]. Mostly these studies have investigated community populations that have a low prevalence of cardiovascular disease [7-9, 12, 13].…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies high ABPI has been associated with increased risk of cardiovascular events in some but not all studies [ 3 , 7 – 9 , 12 – 14 ]. Mostly these studies have investigated community populations that have a low prevalence of cardiovascular disease [ 7 – 9 , 12 , 13 ]. A recent meta-analysis suggested that high ABPI may also be an important prognostic indicator for cardiovascular events in people with established cardiovascular disease [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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High ankle brachial index predicts high risk of cardiovascular events amongst people with peripheral artery disease

et al. 2020

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Ankle-brachial pressure index (ABPI) is commonly measured in people referred to vascular specialists. This study aimed to assess the association of high ABPI (≥ 1.4) with cardiovascular events in people with peripheral artery disease (PAD). 1533 participants with PAD diagnosed by a vascular specialist were prospectively recruited from four out-patient clinics in Australia. ABPI was measured at recruitment and the occurrence of myocardial infarction (MI), stroke or cardiovascular death (major cardiovascular events; MACE) and any amputation were recorded over a median (inter-quartile range) follow-up of 3.3 (1.0–7.1) years. The association of high, compared to normal, low (0.5–0.9) or very low (<0.5), ABPI with clinical events was estimated using Cox proportional hazard analyses, adjusting for traditional risk factors and reported as hazard ratio with 95% confidence intervals. 596 (38.9%), 676 (44.1%), 157 (10.2%) and 104 (6.8%) participants had normal, low, very low and high ABPI, respectively. Participants with high ABPI had increased risk of MACE, MI and death by comparison to those with either normal ABPI [1.69 (1.07, 2.65), 1.93 (1.07, 3.46) and 1.67 (1.09, 2.56)] or either low or very low ABPI [1.51 (1.02, 2.23), 1.92 (1.16, 3.19) and 1.47 (1.02, 2.14)] after adjusting for other risk factors. Findings were similar in a sensitivity analysis excluding people with ABPI only measured in one leg (n = 120). Participants with high ABPI also had an increased risk of MACE and MI compared to those with very low ABPI alone. High ABPI is a strong indicator of excess risk of cardiovascular events amongst people with PAD.

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Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High ankle brachial index predicts high risk of cardiovascular events amongst people with peripheral artery disease

et al. 2020

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“…A medida da PA nos MMII é recomendada para diagnóstico de doença vascular periférica por meio da medida do índice tornozelo-braquial (ITB) (MUNTNER et al, 2019). Outra recomendação sobre esse procedimento é que, em casos de níveis elevados (>140/90 mmHg) e sustentados de PA, a PA deve ser aferida também no membro inferior, e, caso haja uma diferença maior que 10mmHg entre as medidas, o profissional de saúde deve pensar na possibilidade de coarctação de aorta (PENG et al, 2016;YANG et al, 2020).…”

Section: Discussionunclassified

Medida indireta da pressão arterial em membros inferiores: revisão integrativa

Gonçalves¹

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À minha mãe, Cidinha, que não sai da minha cabeça um só minuto, que tanto se orgulha das minhas conquistas e me apoia nos momentos de dificuldade. Todos os dias de trabalho e estudo são dedicados a você que me inspira a ser melhor todos os dias. Obrigada por cada oração, por todas as ligações e por permanecer presente mesmo com toda a distância. Ao meu pai, Nivaldo, por ser exemplo de garra e determinação, que sempre me mostrou o caminho da dedicação aos estudos e me proporcionou as melhores oportunidades. Obrigada pela estrutura familiar em que fui criada e por ter me dado tudo o que precisei para conquistar meus sonhos. À minha irmã e colega de profissão, Laryssa, que compartilha comigo o amor e as dificuldades na Enfermagem, que esteve comigo durante todo o processo do Mestrado e que não me deixou desistir por diversas vezes. Às minhas avós, Clarice e Claudina, que tem por mim um amor imensurável e são exemplos de garra e fé. Obrigada por todas as orações dedicadas aos meus estudos. Ao meu namorado, Alex, que se orgulha a cada conquista e me apoia em todas as escolhas. Obrigada pela companhia e cuidado em cada viagem a Ribeirão Preto, por ser minha alegria e meu refúgio nos momentos difíceis. AGRADECIMENTOS À Deus, por me guiar em todas as escolhas na vida e por me dar forças e luz durante todo o processo de aprendizagem. Á Prof. Dra. Eugenia Velludo Veiga, por ser minha inspiração e por todas as oportunidades que me foram concedidas desde o 1° ano de faculdade, pela amizade, carinho e empenho em me fazer uma enfermeira e mestre de excelência. À Prof. Dra. Ana Carolina Queiroz Godoy Daniel, por todas as valiosas contribuições e pelo incentivo para meu início na área acadêmica. À Prof. Dra. Renata Cristina de Campos Pereira Silveira, pelas contribuições na ocasião do exame de qualificação. A equipe de enfermagem do Hospital de Base e aos pacientes, pelo aprendizado diário, pela confiança e respeito ao meu trabalho e por me ensinarem a arte do cuidar.

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Association of Body Fluid Volumes and Body Fat Distribution with Abnormal Ankle-Brachial Index

et al. 2022

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Background Ankle-brachial index (ABI) is a simple, non-invasive and easy-to-obtain measure for the evaluation of atherosclerotic peripheral arterial disease (PAD). This study aimed to investigate the relationships between body fluid volumes, body composition, body fat distribution and ABI at a population perspective. Results Using the US National Health and Nutrition Examination Survey Data (NHANES) during 1999–2000, 2001–2002, and 2003–2004, adults ≥ 40 years old were eligible for inclusion. Univariate and multivariable linear and logistic regression analyses were performed to determine the associations between ABI, body fluid volume and body composition assessed by bioelectrical impedance analysis (BIA), and body fat distribution assessed by dual-energy X-ray absorptiometry (DEXA). After exclusion, the final analytic sample contained 1535 participants who were representative of totally 28,572,458 subjects in the US. After adjustments for relevant confounders, estimated fat mass was significantly and inversely associated with ABI (beta: − 0.0009, 95% CI = − 0.0015, − 0.0003). Total percent fat (beta: − 0.0024, 95% CI = − 0.0033, − 0.0014), trunk percent fat (beta: − 0.0016, 95% CI = − 0.0023, − 0.0009), and percent fat at the four limbs were also significantly and inversely associated with ABI (p < 0.001). In addition, subjects with higher estimated fat mass, total percent fat, trunk percent fat and higher percent fat at the four limbs were all significantly more likely to have abnormal ABI < 0.9. No significant association between parameters of body fluid volume and abnormal ABI was observed. Conclusions Estimated fat mass, total percent fat, trunk percent fat and percent fat at the four limbs were significantly and inversely associated with ABI. Subjects with abnormal ABI are more likely to have higher total percent fat, trunk percent fat and the limb fat. These findings fill the knowledge gap on the relationships between atherosclerosis and body fat distribution. Further well-designed prospective studies are needed to confirm the present findings.

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Relation between high Ankle-Brachial Index and cardiovascular outcomes in the general population and cardiovascular disease: a meta-analysis

Cited by 7 publications

References 34 publications

High ankle brachial index predicts high risk of cardiovascular events amongst people with peripheral artery disease

High ankle brachial index predicts high risk of cardiovascular events amongst people with peripheral artery disease

Medida indireta da pressão arterial em membros inferiores: revisão integrativa

Association of Body Fluid Volumes and Body Fat Distribution with Abnormal Ankle-Brachial Index

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