Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries

Sade, Leyla Elif; Eroğlu, Serpil; Bozbaş, Hüseyin; Özbiçer, Süleyman; Hayran, Mutlu; Haberal, A; Müderrisoğlu, Haldun

doi:10.1016/j.atherosclerosis.2008.09.038

Cited by 128 publications

(108 citation statements)

References 30 publications

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“…Lin et al [20] also showed that EAT is significantly independently associated with LVDD in patients undergoing peritoneal dialysis. Although the main limitation of all of the above studies is that the authors did not objectively assess the presence of CAD in their study populations, we well know that the association of CAD with LVDD was studied before, and it was shown that CAD is an independent risk factor for LVDD [21]. Also, LVDD is frequently seen in patients with documented CAD, with subclinical atherosclerosis, and even abnormal coronary artery calcium score as recently demonstrated [22,23].…”

Section: Discussionmentioning

confidence: 99%

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Topuz

Doğan

2017

Kardiol Pol

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A b s t r a c t Background and aim:The aim of this study is to evaluate the effect of epicardial adipose tissue (EAT) thickness on left ventricular diastolic functions in patients with normal coronary arteries (NCA) proven by angiography. Methods:We selected study patients who were referred to coronary angiography due to typical chest pain or atypical chest pain with a positive pre-test result for coronary artery disease (CAD). After coronary angiography, 85 patients with significant coronary lesion (≥ 50% stenosis) served as the CAD group, 82 patients with non-significant coronary lesion (< 50% stenosis) and/or a coronary plaque served as the non-significant CAD group, and 83 patients with NCA served as the NCA group. All patients underwent transthoracic echocardiographic examination to measure EAT thickness and left ventricular diastolic properties.Results: Gensini score, total cholesterol, and C-reactive protein were significantly higher in the CAD group compared to the non-significant CAD group and the NCA group. The average of EAT thickness was 7.3 ± 2.4 mm in all groups. It was 5.8 ± 2.3 mm in the NCA group, 6.4 ± 2.4 mm in the non-significant CAD group, and 7.8 ± 2.2 mm in the CAD group (p < 0.001). In correlation analyses, average EAT thickness was significantly correlated with E/e' ratio in the NCA group. In multivariate analysis, average of EAT thickness was significantly associated with left ventricular diastolic dysfunction in subjects with NCA (OR 1.019, 95% CI 1.012-1.027, p < 0.001).Conclusions: Based on our findings, EAT thickness may have an effect on left ventricular diastolic functions. This independent relationship showed us the clinical importance of measuring of EAT thickness.

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Section: Discussionmentioning

confidence: 99%

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Topuz

Doğan

2017

Kardiol Pol

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“…Determining the amount of visceral adipose tissue helps to the determination of high-risk patient group. As shown in previous studies, metabolic syndrome, EFT thickness, and insulin resistance is associated with subclinical atherosclerosis and CVD (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

Ertem¹,

Erayman²,

Efe³

et al. 2014

Anadolu Kardiyol Derg

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Objective: This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness. Methods: Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation between epicardial fat tissue thickness, which was measured by echocardiography and serum paraoxonase 1 level. Also correlation analysis was performed to show correlation between patients' clinical and laboratory findings and the level of serum paraoxonase 1 (PON 1) and the epicardial fat tissue thickness. Pearson and Spearman test were used for correlation analysis. Results: No linear correlation between epicardial fat tissue thickness and serum PON 1 found (correlation coefficient: -0.127, p=0.069). When epicardial fat tissue thickness were grouped as 7 mm and over, and below, and 5 mm and over, and below, serum PON 1 level were significantly lower in ≥7 mm group (PON1 : 168.9 U/L) than <7 mm group (PON 1: 253.9 U/L) (p<0.001). Also hypertension prevalence was increased in ≥7 mm group (p=0.001). Serum triglyceride was found to be higher in ≥7 mm group (p=0.014), body mass index was found higher in ≥5 mm group (p=0.006). Conclusion: Serum PON 1level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness. (Anadolu Kardiyol Derg 2014; 14: 115-20)

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“…In the literature, some studies have been conducted on the relationships between EAT and endothelial dysfunction in patients with or without renal disease. Sade et al demonstrated a negative association between EAT and the coronary flow reserve in patients with angiographically normal coronary arteries 27) . Atakan et al also demonstrated a negative association between the EAT and the coronary flow reserve in 71 patients on chronic hemodialysis 28) .…”

Section: Discussionmentioning

confidence: 99%

A Low Serum Free Triiodothyronine Level is Associated with Epicardial Adipose Tissue in Peritoneal Dialysis Patients

Koçyiğit

Güngör

Ünal

et al. 2014

JAT

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Aim: Cardiovascular disease is a major cause of mortality in dialysis patients. Epicardial adipose tissue (EAT) has been proposed as a cardiovascular risk marker in this population. Subclinical hypothyroidism and low free triiodothyronine (fT3) levels are associated with EAT in patients without chronic renal failure. The aim of this study was to investigate the relationship between EAT and low free T3 levels in peritoneal dialysis (PD) patients. Methods: A total of 125 prevalent PD patients were enrolled in this cross-sectional study. The epicardial fat thickness (EFT) was measured by echocardiography, and the endothelial function was assessed by flow mediated dilatation (FMD). Thyroid function tests were performed by an enzyme immunoassay. Results: The mean age of the patients was 51±13, and the time on PD was 36 months. The mean EFT was 6.7±2.9 mm. The EFT correlated positively with the patient age, systolic blood pressure (BP), mean BP, high sensitivity C-reactive protein (hs-CRP) level and body mass index (BMI), and negatively with the fT3 level and FMD. The median fT3 value was 2.53, and patients were divided according to their serum fT3 values (within the normal range and below the reference level). Compared with patients in the low fT3 group, the subjects in the normal fT3 group had higher serum albumin levels and FMD, but a lower BMI, plasma fasting glucose level, EFT, TSH level, hs-CRP level, low density lipoprotein (LDL) cholesterol level and mean BP in office measurements, and both the diastolic BP and mean BP by ambulatory blood pressure measurement. A multivariate linear regression analysis showed that the EFT was predicted by the hs-CRP and fT3 levels. Conclusion: Low free T3 levels are associated with the epicardial fat thickness in PD patients. Further studies are needed to evaluate the pathogenesis and to support these findings.

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Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries

Cited by 128 publications

References 30 publications

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

A Low Serum Free Triiodothyronine Level is Associated with Epicardial Adipose Tissue in Peritoneal Dialysis Patients

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