Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?

Abstract

Objective: This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness. Methods: Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation between epicardial fat tissue thickness, which was measured by echocardiography and serum paraoxonase 1 level. Also correlation analysis was performed to show correlation between patients' clinical and laboratory findings and the level of serum paraoxonase 1 (PON 1) and the epicardial fat tissue thickness. Pearson and Spearman test were used for correlation analysis. Results: No linear correlation between epicardial fat tissue thickness and serum PON 1 found (correlation coefficient: -0.127, p=0.069). When epicardial fat tissue thickness were grouped as 7 mm and over, and below, and 5 mm and over, and below, serum PON 1 level were significantly lower in ≥7 mm group (PON1 : 168.9 U/L) than <7 mm group (PON 1: 253.9 U/L) (p<0.001). Also hypertension prevalence was increased in ≥7 mm group (p=0.001). Serum triglyceride was found to be higher in ≥7 mm group (p=0.014), body mass index was found higher in ≥5 mm group (p=0.006). Conclusion: Serum PON 1level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness. (Anadolu Kardiyol Derg 2014; 14: 115-20)

The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

“…In other words, the serum PON-1 activity decreases as EATT increases in the patient group with MeS. A recent study by Ertem et al did not establish a significant correlation between EATT and PON-1 in the individuals without any coronary artery disease [ 29 ]. However, they found a negative correlation, as in the present study, between EATT and PON-1 in the subgroup with EATT ≥ 7 mm [ 29 ].…”