The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

Demir, Bülent; Demir, Esra; Açıksarı, Gönül; Uygun, Turgut; Utku, Irem Kirac; Gedikbaşı, Asuman; Caglar, Ilker Murat; Pirhan, Osman; Türeli, Hande Oktay; Oflar, Ersan; Ünğan, İsmail; Ciftci, Serkan; Karakaya, Osman

doi:10.1155/2014/954045

Cited by 21 publications

(20 citation statements)

References 33 publications

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“…Our results demonstrated an increase in the lipid peroxidation in the hypercaloric diet group, which could be due to an elevated production of reactive oxygen species (ROS), an important condition for the development of metabolic syndrome and some disorders such obesity, systemic arterial hypertension (SAH), atherosclerosis, and diabetes [53,54]. However, an increase in the plasma TBARS was prevented by the CI extract or simvastatin treatments.…”

Section: Discussionmentioning

confidence: 72%

Effects of Hydroalcoholic Extract of <em>Celtis iguanaea </em>on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Zanchet

Gomes

Corralo

et al. 2017

Preprint

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Abstract:Celtis iguanaea is popularly used in the treatment of diabetes mellitus. However, thorough chemical and pharmacological investigations regarding its activity are lacking. In this study, we investigated the effects of the hydroalcoholic extract from C. iguanaea (CI) on markers of cardiovascular diseases and the glucose metabolism in cholesterol-fed rats. Therefore, hypercholesterolemic rats (1% cholesterol) were orally treated with CI (150, 300, or 600 mg/kg) or simvastatin (4 mg/kg) (n = 6) once a day for 30 days along with a hypercholesterolemic diet. A control group (C) was given saline solution. CI showed significant decreases in serum levels of total cholesterol, LDL-cholesterol, HMG-CoA-reductase, IL-1, IL-6, TNF−α, and IFN−γ when compared to group C (p ˂ 0.05). Hypoglycemic effects were observed along with a decrease of the activity of sucrase (CI 600), maltase (CI 150, CI 300), and an increase in muscle glycogen levels (CI 300). Antioxidant effects were observed in plasma, and the histopathological analysis showed a significant decrease in the liver fat area for CI compared to group C (p < 0.001). Our results suggest that the biological effects of CI could be related to the presence of flavonoids that possibly exert antioxidant, enzymatic inhibitory, and insulin-mimetic effects.

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Section: Discussionmentioning

confidence: 72%

Effects of Hydroalcoholic Extract of <em>Celtis iguanaea </em>on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Zanchet

Gomes

Corralo

et al. 2017

Preprint

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“…Epicardial adiposity has more markers of oxidative stress than subcutaneous fat tissue [30]. In patients with metabolic syndrome EFTT was associated with systemic oxidative stress [31] and is supposed to play a more important role in the stimulation of systemic oxidative stress than subcutaneous fat tissue. Another possible link between GGT activity and EFTT is insulin resistance which has been previously associated with both, higher levels of GGT [32,33] and increased amount of epicardial fat [22].…”

Section: Resultsmentioning

confidence: 99%

Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

Albu¹,

Moldovan²,

Petra³

et al. 2020

Rev. Chim.

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Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

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“…PCOS is a low-grade chronic inflammatory disease. Many studies have shown a relationship between PCOS and inflammation markers [7,8,26]. There is also a relationship between NRG4 and chronic inflammatory state.…”

Section: Discussionmentioning

confidence: 99%

“…In general, insulin resistance and hyperinsulinemia affect 70 percent of women with PCOS. Despite extensive research, the underlying mechanism of insulin resistance in PCOS has not been fully understood [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: A case-control study

Temür

Çalan²,

Akşit³

et al. 2017

Ginekol Pol

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Objectives: Neuregulin 4 (NRG4) is an adipokine that is synthesized in many tissues and has been shown to be associated with the development of obesity and metabolic disorders in animals and humans. The aim of this study is to investigate the relationship between serum NRG4 levels and various metabolic parameters in women with PCOS. Material and methods:This cross-sectional study included 40 women with PCOS and 40 age-and BMI-matched controls without PCOS. NRG4, fasting blood glucose (FBG), insulin, hs-CRP, LDL-C, HDL-C, SHBG, DHEA-SO 4 and total-testosterone levels were measured in all the participants. HOMA-IR was used to calculate the insulin resistance.Results: Serum NRG4 levels were higher in women with PCOS than in healthy women (24.89 ± 9.32 [ng/mL] vs. 18.98 ± 6.40 [ng/mL], p = 0.002). FBG, LDL-C, HDL-C, LH, SHBG, FAI, DHEA-SO4, insulin, hs-CRP, HOMA-IR and total-testosterone levels were significantly higher in women with PCOS than controls. Circulating NRG4 levels were positively correlated with HOMA-IR, insulin and hs-CRP for both groups. There was a positive correlation between NRG4 and FBG in the PCOS group. HOMA-IR and hs-CRP were associated with NRG4. Conclusion:The high concentration of circulating NRG4 in PCOS may be associated with insulin resistance and low-grade chronic inflammation.

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The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach

Cited by 21 publications

References 33 publications

Effects of Hydroalcoholic Extract of <em>Celtis iguanaea </em>on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Effects of Hydroalcoholic Extract of <em>Celtis iguanaea </em>on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: A case-control study

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