Relation between deranged antioxidant system and cervical neoplasia

Kim, Y. T.; Kim, Jae Wook; Choi, Jihun; Kim, S. H.; Choi, Eunhee; Cho, Namhoon

doi:10.1111/j.1048-891x.2004.14526.x

Cited by 19 publications

(6 citation statements)

References 11 publications

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“…Moreover, the concentration was significantly lower in women with a more advanced tumor status. Since it is known that β-carotene affects cell division processes and prevents abnormal cell development, an adequate amount of β-carotene is important (6) in maintaining healthy tissue.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Vitamins and Lipid Peroxidation in Patients with Cervical Intraepithelial Neoplasia

et al. 2005

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The purpose of this study was to investigate the implications of dietary intake and the level of plasma antioxidant, lipid peroxidation, and antioxidant capacity in Korean women with cervical intraepithelial neoplasia (CIN). From October 2002 to March 2003, 58 patients diagnosed with CIN (confirmed with colposcopy directed biopsy) and 86 patients without any cervical disease as control group were enrolled in the study at the Department of Gynecology cancer center at Samsung Cheil Hospital. The intake of antioxidant vitamins in both groups exceeded the amount recommended by the Korea RDA, 7th edition. The plasma concentration of Vitamin C was significantly lower in the CIN group (0.36 mg/dL) than in the control group (0.48 mg/dL) (p<0.05). The two groups showed similar plasma concentrations of β-carotene, α-tocopherol, and retinol. The average concentration of malondialdehydes in the CIN group, 7.23 mmol/mL, was significantly higher than in the control group, 5.18 mmol/mL (p<0.01). The total radical trapping antioxidant potential concentration of plasma was significantly higher in the CIN group (1.15 mM) than in the control group (1.25 mM) (p<0.05). These results suggest that there is a possible correlation between cervical intraepithelial neoplastic processes and changes in the plasma antioxidative system.

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Section: Discussionmentioning

confidence: 99%

“…Excessive levels of reactive aldehydes such as malondialdehydes (MDA), a product of lipid peroxidation initiated by ROS, could alter the cellular function and lead to cancer formation (6-12). …”

Section: Introductionmentioning

confidence: 99%

Antioxidant Vitamins and Lipid Peroxidation in Patients with Cervical Intraepithelial Neoplasia

et al. 2005

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“…Dietary antioxidants can, in some cases, supplement the activity of endogenous antioxidants found in normal cells and fortify them against challenges posed by increased levels of ROS. In the case of cervical cancer, studies have shown that several antioxidants, such as reduced glutathione, GPx, glutathione-S-transferase, SOD and antioxidant vitamins (vitamin E, vitamin C, lutein, beta-carotene, lycopene and zeaxanthin), are reduced in the circulation of cervical cancer patients [ 249 , 250 ]. In contrast, the concentration of the lipid peroxidation parameter, malondialdehyde, was significantly higher in women with CIN or invasive cervical cancer [ 250 ].…”

Section: Prevention and Reduction Of Risk Factors For Cancersmentioning

confidence: 99%

“…In the case of cervical cancer, studies have shown that several antioxidants, such as reduced glutathione, GPx, glutathione-S-transferase, SOD and antioxidant vitamins (vitamin E, vitamin C, lutein, beta-carotene, lycopene and zeaxanthin), are reduced in the circulation of cervical cancer patients [ 249 , 250 ]. In contrast, the concentration of the lipid peroxidation parameter, malondialdehyde, was significantly higher in women with CIN or invasive cervical cancer [ 250 ]. That may be due to the increased utilization of the antioxidants to scavenge oxidative stress-induced lipid peroxidation and their sequestration by tumor cells.…”

Section: Prevention and Reduction Of Risk Factors For Cancersmentioning

confidence: 99%

Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

Chen

Williams

Filippova

et al. 2014

Cancers

109

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Viruses are the causative agents of 10%–15% of human cancers worldwide. The most common outcome for virus-induced reprogramming is genomic instability, including accumulation of mutations, aberrations and DNA damage. Although each virus has its own specific mechanism for promoting carcinogenesis, the majority of DNA oncogenic viruses encode oncogenes that transform infected cells, frequently by targeting p53 and pRB. In addition, integration of viral DNA into the human genome can also play an important role in promoting tumor development for several viruses, including HBV and HPV. Because viral integration requires the breakage of both the viral and the host DNA, the integration rate is believed to be linked to the levels of DNA damage. DNA damage can be caused by both endogenous and exogenous factors, including inflammation induced by either the virus itself or by co-infections with other agents, environmental agents and other factors. Typically, cancer develops years to decades following the initial infection. A better understanding of virus-mediated carcinogenesis, the networking of pathways involved in transformation and the relevant risk factors, particularly in those cases where tumorigenesis proceeds by way of virus integration, will help to suggest prophylactic and therapeutic strategies to reduce the risk of virus-mediated cancer.

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“…Lower GSH-Px activity, lower plasma antioxidant vitamin levels and higher MDA concentrations were documented in women suffering from cervical intraepithelial neoplasia or invasive cervical cancer compared to women in the Control Group. 7 Higher MDA levels were also reported in cervical cancer patients compared to controls, 8 along with lower levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and GSH-Px.…”

Section: Introductionmentioning

confidence: 97%

Human papillomavirus infection and cervical cancer precursor lesions in women living by Amazon rivers: investigation of relations with markers of oxidative stress

Borges

Brito

Fuzii

et al. 2018

Einstein (São Paulo)

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Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions.Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels.Results Malondialdehyde, total and oxidized glutathione concentrations did not differ significantly (p>0.05) between women with and without low-grade squamous intraepithelial lesions across communities. Malondialdehyde levels (8.02nmols/mL) were almost five times higher in human papillomavirus-positive compared to human papillomavirus-negative women (1.70nmols/mL) living in Itaituba (statistically significant difference; p<0.05). Malondialdehyde levels did not differ significantly (p>0.05) between human papillomavirus-positive and human papillomavirus-negative women living in remaining communities. Significant (p<0.05) differences in total glutathione levels between human papillomavirus-positive and human papillomavirus-negative women (8.20μg/mL and 1.47μg/mL, respectively) were limited to those living in Bragança.Conclusion Malondialdehyde and total glutathione levels were significantly associated with human papillomavirus infection. However, lack of similar associations with squamous lesions suggest oxidative stress alone does not explain correlations with cervical carcinogenesis. Other factors may therefore be involved.

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Relation between deranged antioxidant system and cervical neoplasia

Cited by 19 publications

References 11 publications

Antioxidant Vitamins and Lipid Peroxidation in Patients with Cervical Intraepithelial Neoplasia

Antioxidant Vitamins and Lipid Peroxidation in Patients with Cervical Intraepithelial Neoplasia

Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration

Human papillomavirus infection and cervical cancer precursor lesions in women living by Amazon rivers: investigation of relations with markers of oxidative stress

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