Relation between chronic endometritis and recurrent miscarriage

Farghali, Mohamed M.; Abdelazim, Ibrahim A.; El-Ghazaly, Tamer E

doi:10.5114/pm.2021.109769

Cited by 5 publications

(23 citation statements)

References 17 publications

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“…Few attentions have been paid on the underlying effect of CE on neonatal outcomes previously. Exposure to chronic inflammatory uterine environmental risk factors may provoke a certain degree of toxicity to embryo development and pregnancy maintenance 19 . As CE is mostly caused by genital tract infections with kinds of pathogens, 20 we supposed CE may play roles in inflammatory complications.…”

Section: Discussionmentioning

confidence: 95%

“…Exposure to chronic inflammatory uterine environmental risk factors may provoke a certain degree of toxicity to embryo development and pregnancy maintenance. 19 As CE is mostly caused by genital tract infections with kinds of pathogens, 20 we supposed CE may play roles in inflammatory complications. Uterine inflammation and microbial proliferation can directly damage the fetal membranes and result in intrauterine infection resulting in PROM.…”

Section: Discussionmentioning

confidence: 99%

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Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Zhang

Yang

Xiong

et al. 2023

American J Rep Immunol

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Problem The impact of antibiotic‐cured chronic endometritis (CE) on perinatal outcomes of patients conceived with frozen embryo transfer (FET) was unclear. Method This study was to re‐evaluate the perinatal outcomes of a cohort of infertile patients who had undergone endometrial biopsy for CE detection from February 2018 to December 2019 and successfully delivered babies after FET. The study population was divided into two groups: the non‐CE (NCE) group (0‐4/HPF CD138) and the cured‐CE (CCE) group (CD138+/HPF≥5 and has been cured after one or two rounds of antibiotic treatment). For subgroup analysis, the NCE group was further divided into subgroup 1 (CD138+/HPF = 0), subgroup 2 (CD138+/HPF = 1‐4 with antibiotic treatment), and subgroup 3 (CD138+/HPF = 1‐4 without antibiotic treatment) Results A total of 321 live births, including 210 in the NCE group and 111 in the CCE group were analyzed. The prevalence rates of premature rupture of the membrane and preterm birth were comparable between NCE and CCE (6.2% vs. 7.1% and 10.8% vs. 10.1%, respectively) groups. In addition, no differences were detected in the rates of placenta‐mediated complications, such as preeclampsia, placenta abruption, or low birthweight. Multiple logistic analyses confirmed that CCE was not associated with an increased risk of any adverse perinatal outcomes. Subgroup analysis in NCE failed to find any significant differences in the incidences of obstetrical and neonatal complications. Conclusions CCE might not increase the risks of adverse perinatal outcomes after antibiotic treatment.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Zhang

Yang

Xiong

et al. 2023

American J Rep Immunol

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“…The sample size was calculated using G Power software version 3.1.9.7 [ 17 ], and χ 2 test. The qualitative variables were analysed using the χ 2 test to detect the menstrual changes after the thromboprophylaxis or anticoagulants used during the COVID-19 infection.…”

Section: Methodsmentioning

confidence: 99%

Menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection

Bakr,

El-Feky,

Abdelazim

et al. 2023

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Introduction To detect the menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection. Material and methods A total of 176 diagnosed with COVID-19 infection, were included in this retrospective study after giving informed consent. Participants were asked to complete an online questionnaire, and the collected participants` data were analysed using the χ 2 test to detect the menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection. Results The number of participants` number who reported menstrual flow for 2 to < 5 days, and menstrual flow > 7 days after the COVID-19 infection [31/176 (17.6%), and 42/176 (23.9%), respectively] was significantly higher compared to the number of participants` who reported menstrual flow for 2 to < 5 days, and menstrual flow > 7 days before the COVID-19 infection [12/176 (6.8%), and 15/176 (8.5%), respectively], ( p = 0.005, and 0.0009, respectively). The use of thrombo-prophylaxis or anticoagulants during the COVID-19 infection was also associated with significant menstrual pattern changes (37.8% increased menstrual flow, 18.5% menstrual flow for 2 to < 5 days, 59.7% menstrual flow > 7 days, 5.9% contact bleeding, and 6.7% abnormal menstrual pattern for one cycle). Conclusions Significant menstrual changes were observed in this study after the COVID-19 infection infection (17.6% reported menstrual flow for 2 to < 5 days, and 23.9% reported menstrual flow > 7 days). The use of thrombo-prophylaxis or anticoagulants during the COVID-19 infection infection was associated with significant menstrual changes (37.8% increased menstrual flow, 18.5% menstrual flow for 2 to < 5 days, 59.7% menstrual flow > 7 days, 5.9% contact bleeding, and 6.7% abnormal menstrual pattern for one cycle).

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“…CE is a persistent inflammation of the endometrial lining, whose estimated incidence in infertile women ranges from 0.2 to 46% [ 4 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Plasma Cells as a Marker of Chronic Endometritis: A Systematic Review and Meta-Analysis

et al. 2023

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Chronic endometritis (CE) is the persistent inflammation of the endometrial lining associated with infertility and various forms of reproductive failures. The diagnosis of CE is based on the histological evidence of stromal plasma cells; however, standardized methods to assess plasma cells are still lacking. In the present paper, we aimed to determine the most appropriate plasma cell threshold to diagnose CE based on pregnancy outcomes. Three electronic databases were searched from their inception to February 2022 for all studies comparing pregnancy outcomes between patients with CE and patients without CE. The relative risk (RR) of pregnancy, miscarriage, and/or live birth rates were calculated and pooled based on the plasma cell threshold adopted. A p-value < 0.05 was considered significant. Nine studies adopting different thresholds (1 to 50 plasma cells/10 HPF) were included. In the meta-analysis, we only found a significant association between miscarriage rate and a plasma cell count ≥ 5/10 HPF (RR = 2.4; p = 0.007). Among studies not suitable for meta-analysis, CE showed an association with worsened pregnancy only when high thresholds (10 and 50/10 HPF) were adopted. In conclusion, our study suggests that the presence of plasma cells at low levels (<5/10 HPF) may not predict worsened pregnancy outcomes. Based on these findings, a threshold of ≥5 plasma cells/10 HPF may be more appropriate to diagnose CE.

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Relation between chronic endometritis and recurrent miscarriage

Cited by 5 publications

References 17 publications

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection

The Role of Plasma Cells as a Marker of Chronic Endometritis: A Systematic Review and Meta-Analysis

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