Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Abstract

Problem The impact of antibiotic‐cured chronic endometritis (CE) on perinatal outcomes of patients conceived with frozen embryo transfer (FET) was unclear. Method This study was to re‐evaluate the perinatal outcomes of a cohort of infertile patients who had undergone endometrial biopsy for CE detection from February 2018 to December 2019 and successfully delivered babies after FET. The study population was divided into two groups: the non‐CE (NCE) group (0‐4/HPF CD138) and the cured‐CE (CCE) group (CD138+/HPF≥5 and has been cured after one or two rounds of antibiotic treatment). For subgroup analysis, the NCE group was further divided into subgroup 1 (CD138+/HPF = 0), subgroup 2 (CD138+/HPF = 1‐4 with antibiotic treatment), and subgroup 3 (CD138+/HPF = 1‐4 without antibiotic treatment) Results A total of 321 live births, including 210 in the NCE group and 111 in the CCE group were analyzed. The prevalence rates of premature rupture of the membrane and preterm birth were comparable between NCE and CCE (6.2% vs. 7.1% and 10.8% vs. 10.1%, respectively) groups. In addition, no differences were detected in the rates of placenta‐mediated complications, such as preeclampsia, placenta abruption, or low birthweight. Multiple logistic analyses confirmed that CCE was not associated with an increased risk of any adverse perinatal outcomes. Subgroup analysis in NCE failed to find any significant differences in the incidences of obstetrical and neonatal complications. Conclusions CCE might not increase the risks of adverse perinatal outcomes after antibiotic treatment.

Efficacy of Combined Treatment with Clindamycin and Ultrasound in Chronic Pelvic Inflammatory Disease

“…Hence, proactive treatment is imperative in clinical practice [1,2] . Presently, the treatment modalities for chronic PID encompass antibiotic therapy, physiotherapy, and surgical measures [3][4][5][6][7][8] . Classified under the lincosamide class of antibiotics, clindamycin phosphate exerts its antibacterial effects by converting into clindamycin in the body.…”