Relation between bone mineral density
and IL-17 serum levels in Serbian patients with
early Rheumatoid arthritis

Pavlović, Voja; Dimić, Aleksandar; Milenković, Saša; Krtinić, Dane; Aleksić, Ivana

doi:10.1515/med-2015-0019

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…All patients involved in the trials met the criteria of the American College of Rheumatology from 2010 as well as other criteria described in the previous study. [1011121314] The patients were divided into two groups: Group I patients - no visible changes in the macula (26 patients) and Group II patients - with visible changes in the macula (30 patients). Patients with glaucoma, ocular hypertension, optic nerve diseases, diabetes, diseases of the retina and the macula, uveitis, chorioretinitis, defects in the visual field, including the central 10 degrees, prior ophthalmic surgery, and larger refractive errors (greater than ± 6D spheres and/or greater than ± 3D cylinder) were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy

Božinović

Stanković-Babić

Petrovič³

et al. 2019

J Res Med Sci

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Background: Chloroquine and hydroxychloroquine are drugs that are primarily used for the treatment of malaria and are also recommended for treating connective tissue disorders, autoimmune diseases, and some dermatological and inflammatory diseases. Treatment with these drugs has potential risk for the development of retinopathy, clinically characterized by bilateral pigment changes in the macula, as one serious ocular complication. The aim of this research was to evaluate the parafoveal and perifoveal macular retinal thickness, as central foveal thickness in adult patients with rheumatoid arthritis (RA) on chloroquine therapy using optical coherence tomography (OCT). Materials and Methods: In this cross-sectional study, 56 RA patients (56 eyes) were included and examined. All patients were treated with chloroquine (tablets resochin or delagil) at a dose of 250 mg/day without treatment with steroids and other immunosuppressive drugs. Patients were divided into two groups, namely, Group I patients - no visible changes in the macula (26 patients) and Group II patients- with visible changes in the macula (30 patients). The central fovea thickness and parafoveal and perifoveal retinal thickness in all quadrants were measured by OCT and compared in both groups. Results: There are a significantly higher number of eyes without thinning of the macula in Group I patients than in Group II ( P < 0.001) patients. There are a higher number of patients with recorded parafoveal thinning in Group II patients, especially in the inferior, nasal, and temporal sectors, respectively ( P < 0.05). Conclusion: Maculopathy is the main side effect of chloroquine therapy in RA patients that can be detected by OCT in the early stages of the macular involvement.

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Section: Methodsmentioning

confidence: 99%

Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy

Božinović

Stanković-Babić

Petrovič³

et al. 2019

J Res Med Sci

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show abstract

“…Both agreeing and conflicting results can be found in the literature. For example, one study reported that IL-17, but not IL-4, was moderately correlated with DAS28ESR and ESR [ 49 ], while another reported that IL-17 did not correlate with either DAS28 [ 50 ] or ESR [ 50 , 51 ]. These discrepancies may have resulted from differences between study populations (e.g., regarding age, disease severity, disease stage, proportion of males and females, genetic background, comorbidities, or medications), technical differences (e.g., regarding medical practices or data collection and analysis), or a combination of both.…”

Section: Discussionmentioning

confidence: 99%

The Fidelity of Rheumatoid Arthritis Multivariate Diagnostic Biomarkers Using Discriminant Analysis and Binary Logistic Regression

Hassan,

Othman,

Daghestani

et al. 2023

Biomolecules

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Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that causes multi-articular synovitis. The illness is characterized by worsening inflammatory synovitis, which causes joint swelling and pain. Synovitis erodes articular cartilage and marginal bone, resulting in joint deterioration. This bone injury is expected to be permanent. Cytokines play a prominent role in the etiology of RA and could be useful as early diagnostic biomarkers. This research was carried out at Riyadh’s King Khalid University Hospital (KKUH). Patients were enrolled from the Rheumatology unit. Seventy-eight RA patients were recruited (67 (85.9%) females and 11 (14.1%) males). Patients were selected for participation by convenience sampling. Demographic data were collected, and disease activity measurements at 28 joints were recorded using the disease activity score (DAS-28). Age- and sex-matched controls from the general population were included in the study. A panel of 27 cytokines, chemokines, and growth factors was determined in patient and control sera. Binary logistic regression (BLR) and discriminant analysis (DA) were used to analyze the data. We show that multiple cytokine biomarker profiles successfully distinguished RA patients from healthy controls. IL-17, IL-4, and RANTES were among the most predictive variables and were the only biomarkers incorporated into both BLR and DA predictive models for pooled participants (men and women). In the women-only models, the significant cytokines incorporated in the model were IL-4, IL-17, MIP-1b, and RANTES for the BLR model and IL-4, IL-1Ra, GM-CSF, IL-17, and eotaxin for the DA model. The BLR and DA men-only models contained one cytokine each, eotaxin for BLR and platelet-derived growth factor-bb (PDGF-BB) for DA. We show that BLR has a higher fidelity in identifying RA patients than DA. We also found that the use of gender-specific models marginally improves detection fidelity, indicating a possible benefit in clinical diagnosis. More research is needed to determine whether this conclusion will hold true in various and larger patient populations.

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“… 165 , 166 Ankylosing spondylitis (AS), like PsA, causes higher levels of IL-17A in patients’ serum and synovial fluid. 164 , 167 Emerging evidence suggests that IL-17F plays a significant role in spondyloarthritis spectrum illness and psoriasis, and dual inhibition of IL-17A and IL-17 may be beneficial, particularly in the skin. 168 IL-17F production in response to inflammatory stimuli can activate the C/EBP protein, which mediates osteoblastogenesis during early fracture repair.…”

Section: Il-17-driven Physiological Responsesmentioning

confidence: 99%

The IL-17 family in diseases: from bench to bedside

Huangfu,

Li,

Huang

et al. 2023

Sig Transduct Target Ther

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The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research interest, and emerging data have gradually improved our understanding of the IL-17 signaling pathway. However, a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the body. This review can aid researchers in better understanding the mechanisms underlying IL-17’s roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and function. This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17’s role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis. In addition, we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.

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Relation between bone mineral density and IL-17 serum levels in Serbian patients with early Rheumatoid arthritis

Cited by 4 publications

References 39 publications

Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy

Role of optical coherence tomography in the early detection of macular thinning in rheumatoid arthritis patients with chloroquine retinopathy

The Fidelity of Rheumatoid Arthritis Multivariate Diagnostic Biomarkers Using Discriminant Analysis and Binary Logistic Regression

The IL-17 family in diseases: from bench to bedside

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