Relation between blood pressure and pulse wave velocity for human arteries

Ma, Yinji; Choi, Jungil; Hourlier-Fargette, Aurélie; Xue, Yeguang; Chung, Ha Uk; Lee, Jong Yoon; Wang, Xiufeng; Xie, Zhaoqian; Kang, Daeshik; Wang, Heling; Han, Sueng‐Han; Kang, Seung Kyun; Kang, Yisak; Yu, Xinge; Slepian, Marvin J.; Raj, Milan; Model, Jeffrey B.; Feng, Xue; Ghaffari, Roozbeh; Rogers, John A.; Huang, Yonggang

doi:10.1073/pnas.1814392115

Cited by 208 publications

(129 citation statements)

References 32 publications

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“…For example, one can derive the pulse wave velocity by measuring the pulse waves at two points on a vessel, which is a useful indicator of hypertension [2,3], arteriosclerosis [4,5], and diabetes [6,7]. Moreover, previous studies have also demonstrated the relationship between the pulse wave velocity (PWV) and blood pressure [8,9], which indicates the possibility of realizing a wearable cuff-less sensor for continuous measurement of blood pressure by measuring the PWV using two wearable pulse wave sensors.…”

Section: Introductionmentioning

confidence: 99%

MEMS-Based Pulse Wave Sensor Utilizing a Piezoresistive Cantilever

Nguyen

Mizuki

Tsukagoshi

et al. 2020

Sensors

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This paper reports on a microelectromechanical systems (MEMS)-based sensor for pulse wave measurement. The sensor consists of an air chamber with a thin membrane and a 300-nm thick piezoresistive cantilever placed inside the chamber. When the membrane of the chamber is in contact with the skin above a vessel of a subject, the pulse wave of the subject causes the membrane to deform, leading to a change in the chamber pressure. This pressure change results in bending of the cantilever and change in the resistance of the cantilever, hence the pulse wave of the subject can be measured by monitoring the resistance of the cantilever. In this paper, we report the sensor design and fabrication, and demonstrate the measurement of the pulse wave using the fabricated sensor. Finally, measurement of the pulse wave velocity (PWV) is demonstrated by simultaneously measuring pulse waves at two points using the two fabricated sensor devices. Furthermore, the effect of breath holding on PWV is investigated. We showed that the proposed sensor can be used to continuously measure the PWV for each pulse, which indicates the possibility of using the sensor for continuous blood pressure measurement.

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Section: Introductionmentioning

confidence: 99%

MEMS-Based Pulse Wave Sensor Utilizing a Piezoresistive Cantilever

Nguyen

Mizuki

Tsukagoshi

et al. 2020

Sensors

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“…Especially in the biomedical field, electronic devices have to be flexible and/or stretchable in order to intimately integrate with the soft, deformable, and configuration-complicated biological tissue. [25][26][27][28][29][30] Flexibility of the electronic devices can be realized by reducing their thickness, since the bending stiffness decreases at a three orders faster speed with decreasing thickness, while stretchability can be achieved by pre-strain formed wavy configuration, island-bridge structure and serpentine and fractal interconnects design. 23,[31][32][33][34][35][36][37] The main idea in these strategies is to utilize the buckling/post buckling of the delicate patterned inorganic materials to minimize the strain in the functional layer while the whole devices are under large deformation.…”

Section: Introductionmentioning

confidence: 99%

Flexible inorganic bioelectronics

Chen¹,

et al. 2020

Self Cite

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Flexible inorganic bioelectronics represent a newly emerging and rapid developing research area. With its great power in enhancing the acquisition, management and utilization of health information, it is expected that these flexible and stretchable devices could underlie the new solutions to human health problems. Recent advances in this area including materials, devices, integrated systems and their biomedical applications indicate that through conformal and seamless contact with human body, the measurement becomes continuous and convenient with yields of higher quality data. This review covers recent progresses in flexible inorganic bio-electronics for human physiological parameters' monitoring in a wearable and continuous way. Strategies including materials, structures and device design are introduced with highlights toward the ability to solve remaining challenges in the measurement process. Advances in measuring bioelectrical signals, i.e., the electrophysiological signals (including EEG, ECoG, ECG, and EMG), biophysical signals (including body temperature, strain, pressure, and acoustic signals) and biochemical signals (including sweat, glucose, and interstitial fluid) have been summarized. In the end, given the application property of this topic, the future research directions are outlooked.

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“…In fact, the development of wearable devices that can measure pulse wave and respiration rate has been an important research topic, with practical applications in the fields of healthcare, security, and sports [1,2]. Furthermore, continuous pulse wave measurements can be used to develop methods for continuous monitoring of blood pressure [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

MEMS-Based Sensor for Simultaneous Measurement of Pulse Wave and Respiration Rate

Nguyen

Ichiki

2019

Sensors

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The continuous measurements of vital signs (body temperature, blood pressure, pulse wave, and respiration rate) are important in many applications across various fields, including healthcare and sports. To realize such measurements, wearable devices that cause minimal discomfort to the wearers are highly desired. Accordingly, a device that can measure multiple vital signs simultaneously using a single sensing element is important in order to reduce the number of devices attached to the wearer’s body, thereby reducing user discomfort. Thus, in this study, we propose a device with a microelectromechanical systems (MEMS)-based pressure sensor that can simultaneously measure the blood pulse wave and respiration rate using only one sensing element. In particular, in the proposed device, a thin silicone tube, whose inner pressure can be measured via a piezoresistive cantilever, is attached to the nose pad of a pair of eyeglasses. On wearing the eyeglasses, the tube of sensor device is in contact with the area above the angular artery and nasal cavity of the subject, and thus, both pulse wave and breath of the subject cause the tube’s inner pressure to change. We experimentally show that it is possible to extract information related to pulse wave and respiration as the low-frequency and high-frequency components of the sensor signal, respectively.

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Relation between blood pressure and pulse wave velocity for human arteries

Cited by 208 publications

References 32 publications

MEMS-Based Pulse Wave Sensor Utilizing a Piezoresistive Cantilever

MEMS-Based Pulse Wave Sensor Utilizing a Piezoresistive Cantilever

Flexible inorganic bioelectronics

MEMS-Based Sensor for Simultaneous Measurement of Pulse Wave and Respiration Rate

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