Relation between antral motility and gastric emptying of solids and liquids in humans

Abstract

Our aim was to test the hypothesis that there is a relation between antral phasic pressure activity and the emptying of solids and liquids from the intact human stomach after a mixed meal. This hypothesis was evaluated in 14 healthy individuals in whom we performed simultaneous antral manometry and radioscintigraphy after ingestion of a meal labeled with [99mTc]sulfur colloid in cooked egg (solid component) and [111In]DTPA (liquid component). Analysis of the data included an in-depth evaluation of different models for expressing both gastric emptying rates and antral pressure activity. We found that gastric emptying was adequately represented by a two-phase model consisting of lag and emptying periods and by a power exponential model for the liquid phase. Distal antral motility was accurately represented by the slope of the cumulative antral motility index. During the lag period for solids, the antral motility was inversely related to the duration of the lag. During the solid-emptying period, there was a positive correlation between emptying of solids and antral motility. No significant relation was found between antral motility and overall emptying of the liquid phase of the meal. However, a relationship was found when antral motility was related to liquid emptying after an initial lag period for solids. These human data are consistent with a role of antral pressure activity in trituration of solid food and a role of the antrum in the subsequent propulsion of solids and liquids from the stomach.

Effects of the 5‐HT3 receptor antagonist ICS 205‐930 on fat‐delayed gastric emptying and antral motor activity.

“…The results of the present study show that 10 mg ICS 205-930 had virtually no effect on gastric emptying, whereas after 20 mg ICS 205-930, (Camilleri et al, 1985;Houghton et al, 1986) but also of liquid (Stemper & Cooke, 1975;Weisbrodt et al, 1969) and semisolid meals (Stacher et al, 1984(Stacher et al, , 1987. The frequency and the propagation velocity of antral contractions were influenced by ICS 205-930 but to a minor degree.…”

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

“…Among them, gastric antral motility is regarded as one of the main regulators of gastric emptying of solid meals [15]. A previous report described that emptying rates for the entire gastric contents are correlated with antral motor activity during the active emptying phase for solids in humans [4]. We adopted the 13 C-octanoic acid breath test as a comparative test because this method correlates with a gold standard of gastric emptying, scintigraphy, in humans [6].…”

Endoscopic Ultrasound-Guided Gastric Botulinum Toxin Injections in Obese Subjects: A Pilot Study

“…Prior studies demonstrated the importance of gastric antral contractility to the normal emptying of solids [19]. Reduced antral motility is associated with retardation of gastric emptying with prolongation of the lag time and gastric emptying half-time (T 1/2 ), and a slower post-lag gastric emptying phase [20].…”