Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics: a framework for tracking neurodegenerative disease

McColgan, Peter; Helbling, Saskia; Vaculciakov, Lenka; Pine, Kerrin; Wagstyl, Konrad; Attar, Fakhereh Movahedian; Edwards, Luke; Papoutsi, Marina; Wei, Yongbin; Heuvel, Martijn P. van den; Tabrizi, Sarah J; Rees, Geraint; Weiskopf, Nikolaus

doi:10.1101/2020.02.05.935080

Cited by 4 publications

References 76 publications

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Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

Zarkali,

Thomas,

Zetterberg

et al. 2024

Nat Commun

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A major challenge in Parkinson’s disease is the variability in symptoms and rates of progression, underpinned by heterogeneity of pathological processes. Biomarkers are urgently needed for accurate diagnosis, patient stratification, monitoring disease progression and precise treatment. These were previously lacking, but recently, novel imaging and fluid biomarkers have been developed. Here, we consider new imaging approaches showing sensitivity to brain tissue composition, and examine novel fluid biomarkers showing specificity for pathological processes, including seed amplification assays and extracellular vesicles. We reflect on these biomarkers in the context of new biological staging systems, and on emerging techniques currently in development.

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Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

Zarkali,

Thomas,

Zetterberg

et al. 2024

Nat Commun

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The human motor cortex microcircuit: insights for neurodegenerative disease

et al. 2020

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The human motor cortex is selectively vulnerable in a number of neurodegenerative diseases. In this review McColgan et al. integrate layer-specific physiology and pathobiology in the motor cortex thereby generating hypotheses that can be tested in humans using ultra-high resolution neuroimaging techniques. Glossary Anti-sense oligonucleotide therapies-These are single stranded DNA molecules, which bind to target pre-mRNA and recruit RNAse H causing degradation of the complex. This approach has already been applied to a number of neurodegenerative disease including Huntington's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Alzheimer's disease. Fusiform-This refers to a spindle shape, which is wide in the middle and tapers at both ends. Piriform-This refers to a pear shape, from the latin from pirum "pear" and forma "shape". 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-This is a compound which can cross the blood brain barrier were it is then converted into 1-methyl-4-phenylpyridinium (MPP+), a neurotoxin, which causes selective and permanent destruction of dopaminergic neurons in the substania nigra. Vibrotactile discrimination-This is an experimental design were stimuli of two different frequencies are applied to the hand and the participant is asked to discriminate between the low and high frequency stimuli. Infragranular layers-These are cortical layers 5 and 6, which are below the granular layer 4 in the neocortex. Supergranular layers-These are cortical layers 1 to 3, which are above the granular layer 4 in the neocortex. Hyperkinetic-This relates to increased or excessive movement, such as tremor in Parkinson's disease or chorea in Huntington's disease Hypokinetic-This relates to reduced or slowed movement, such as reduced fine finger movements and rigidity seen in Parkinson's disease. Magnetic resonance spectroscopy-This technique detects radiofrequency electromagnetic signals that are produced by the atomic nuclei within molecules. It can be used to obtain measures of chemicals in the brain, such as N-acetylasparate, creatine, glutamate and GABA.

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Combining Navigator and Optical Prospective Motion Correction for High-Quality 500 μm Resolution Quantitative Multi-Parameter Mapping at 7T

Vaculčiaková

Podranski

Edwards

et al. 2021

Preprint

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PURPOSEHigh-resolution quantitative multi-parameter mapping shows promise for non-invasively characterizing human brain microstructure but is limited by physiological artifacts. We implemented corrections for rigid head movement and respiration-related B0-fluctuations and evaluated them in healthy volunteers and dementia patients.METHODSCamera-based optical prospective motion correction (PMC) and free-induction decay (FID) navigator correction were implemented in a gradient and RF-spoiled multi-echo 3D gradient echo sequence for mapping proton density (PD), longitudinal relaxation rate (R1) and effective transverse relaxation rate (R2*). We studied their effectiveness separately and in concert in young volunteers and then evaluated the navigator correction (NAVcor) with PMC in a group of elderly volunteers and dementia patients. We used spatial homogeneity within white matter (WM) and gray matter (GM) and scan-rescan measures as quality metrics.RESULTSNAVcor and PMC reduced artifacts and improved the homogeneity and reproducibility of parameter maps. In elderly participants, NAVcor improved scan-rescan reproducibility of parameter maps (coefficient of variation decreased by 14.7% and 11.9% within WM and GM respectively). Spurious inhomogeneities within WM were reduced more in the elderly than in the young cohort (by 9% vs 2%). PMC increased regional GM/WM contrast and was especially important in the elderly cohort, which moved twice as much as the young cohort. We did not find a significant interaction between the two corrections.CONCLUSIONNavigator correction and PMC significantly improved the quality of PD, R1 and R2* maps, particularly in less compliant elderly volunteers and dementia patients.

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Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics: a framework for tracking neurodegenerative disease

Cited by 4 publications

References 76 publications

Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions

The human motor cortex microcircuit: insights for neurodegenerative disease

Combining Navigator and Optical Prospective Motion Correction for High-Quality 500 μm Resolution Quantitative Multi-Parameter Mapping at 7T

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