2018
DOI: 10.3390/biomedicines6030084
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Relapsing Polychondritis: An Updated Review

Abstract: Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the d… Show more

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Cited by 90 publications
(137 citation statements)
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“…Given the rarity of the disease, there are no evidencebased guidelines. Besides the above-mentioned treatment options, less severe cases can be treated with colchicine 0.6 mg PO two to four times a day and nonsteroidal antiinflammatory drugs [3].…”
Section: Dear Editorsmentioning
confidence: 99%
“…Given the rarity of the disease, there are no evidencebased guidelines. Besides the above-mentioned treatment options, less severe cases can be treated with colchicine 0.6 mg PO two to four times a day and nonsteroidal antiinflammatory drugs [3].…”
Section: Dear Editorsmentioning
confidence: 99%
“…Relapsing polychondritis (RP) is a rare autoimmune disorder of unknown etiology that primarily affects cartilaginous tissues [1]. RP is characterized by recurrent episodes of inflammation, that causes progressive anatomical deformation and functional impairment of primarily the auricular cartilage, the nasal cartilage, and the respiratory tract [1,2].…”
Section: Introductionmentioning
confidence: 99%
“…Relapsing polychondritis (RP) is a rare autoimmune disorder of unknown etiology that primarily affects cartilaginous tissues [1]. RP is characterized by recurrent episodes of inflammation, that causes progressive anatomical deformation and functional impairment of primarily the auricular cartilage, the nasal cartilage, and the respiratory tract [1,2]. McAdam et al [3] proposed that RP can be diagnosed when three or more of these features are present, along with a positive biopsy from the affected tissue: (1) recurrent chondritis of both auricles; (2) nonerosive inflammatory polyarthritis; (3) chondritis of nasal cartilage; (4) inflammation of ocular structures, including conjunctivitis, keratitis, scleritis, episcleritis, and uveitis; (5) chondritis in the respiratory tract involving laryngeal and/or tracheal cartilages; and (6) cochlear and/or vestibular damage manifesting as sensorineural hearing loss, tinnitus, or vertigo.…”
Section: Introductionmentioning
confidence: 99%
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“…Neben den oben genannten Therapien können in weniger schweren Fällen noch Colchicin 0,6 mg 2-4-mal täglich p.o. und nichtsteroidale Antirheumatika eingesetzt werden [3].…”
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