Relapsing cutaneous polyarteritis nodosa associated with streptococcal infections

Ma, Albornoz; Av, Benedetto; Korman, Michael; McFall, S; Cd, Tourtellotte; Ar, Myers

doi:10.1046/j.1365-4362.1998.00493.x

Cited by 39 publications

(14 citation statements)

References 20 publications

(30 reference statements)

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“…Several infectious and noninfectious conditions have been associated both to initiation and relapse of the disease (2, 5, 7). Among them, streptococcal infection has been commonly implicated (6, 8). Although some evidence of streptococcal infection as an initiating factor for CPAN is present, caution must be exercised when interpreting elevations in the serologic markers of streptococcal infection in the absence of an appropriate clinical presentation.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Polyarteritis Nodosa Presented with Digital Gangrene: A Case Report

et al. 2006

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Cutaneous polyarteritis nodosa (CPAN) is an uncommon form of vasculitis involving small and medium sized arteries of unknown etiology. The disease can be differentiated from polyarteritis nodosa by its limitation to the skin and lack of progression to visceral involvement. The characteristic manifestations are subcutaneous nodule, livedo reticularis, and ulceration, mostly localized on the lower extremity. Arthralgia, myalgia, peripheral neuropathy, and constitutional symptoms such as fever and malaise may also be present. We describe a 34-yr-old woman presented with severe ischemic change of the fingertip and subcutaneous nodules without systemic manifestations as an unusual initial manifestation of CPAN. Therapy with corticosteroid and alprostadil induce a moderate improvement of skin lesions. However, necrosis of the finger got worse and the finger was amputated.

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Section: Discussionmentioning

confidence: 99%

“…Various factors have been implicated including drugs, tuberculosis, hepatitis, and streptococcal infections (2, 6, 7). This disorder represents a chronic and benign course that exhibits a tendency towards relapses and remissions (2, 8). …”

Section: Introductionmentioning

confidence: 99%

Cutaneous Polyarteritis Nodosa Presented with Digital Gangrene: A Case Report

et al. 2006

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“…However, the patient had no history of conditions predisposing to atherosclerosis and arterial embolism, such as hypertension, diabetes, hyperlipidaemia or cardiac arrhythmias. Streptococcal infection has been implicated in relapse of CPN, 5 but the patient had no infection before admission. We prescribed minocycline hydrochloride to reduce inflammation in our patient; there are several reports on minocycline‐induced CPN, 6 which are closely associated with the presence of myeloperoxidase ANCA and improved by discontinuation of minocycline.…”

Section: Reportmentioning

confidence: 96%

Revascularization by percutaneous transluminal angioplasty improved abruptly deteriorated ischaemic symptoms in cutaneous polyarteritis nodosa

Osada

Akiyama

Takasaki

et al. 2011

Clinical and Experimental Dermatology

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We report a patient with cutaneous polyarteritis nodosa, who had a 3-year history of recurrent leg and foot ulcers. Symptoms of ischaemia in the left foot, including severe pain, coldness, paraesthesia and violaceous discoloration, deteriorated abruptly, because of complete occlusion of the left anterior tibial artery. The occluded segment was revascularized by percutaneous transluminal angioplasty, resulting in a dramatic improvement in the ischaemic symptoms.

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“…Çe itli enfeksiyöz durumlar hastal n ba lang c nda ve tekrarlar nda sorumlu olabilir. Özellikle streptokoklar patogenezde rol alan enfeksiyöz ajanlard r. Literatürde üst solunum yolu enfeksiyonlar ve Mycobacterium tuberculosis enfeksiyonlar ile birlikteli i bildirilmi tir (1,4,5). Hepatit B ve C virüsleri sistemik PAN patogenezinde suçlan rken nadiren izole kutanöz PAN olgular nda da saptanabilir (6,7).…”

Section: Tart Maunclassified

Cutaneous Polyarteritis Nodosa

Demirel¹,

Utaş²,

Kontaş³

2010

Turk J Dermatol

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ÖzetKutanöz poliarteritis nodoza (PAN), visseral tutulumun olmadığı ve iyi prognozlu poliarteritis nodoza varyantıdır. En sık görülen deri lezyonu bacakların alt kısımlarında lokalize nodüllerdir. İyi seyirli olmasına rağmen relapslar ve ilerleyen yıllarda sistemik tutulum izlenebilir. Burada yaklaşık bir aydır bacakta ağrılı, eritemli nodülleri olan ve selülit tanısı ile defalarca farklı antibiyotikler kullanan bir kutanöz PAN olgusu sunulmaktadır. Hasta sistemik steroid tedavisi ile iyileşmesine rağmen, tedaviden sonraki üçüncü ayda aynı şikayetlerle yeniden başvurmuştur. Hastalığın tekrarlaması nedeniyle daha önce birkaç kez selülit tanısı konulan ve bu şekilde tedavi edilmeye çalışılan olgu, kutanöz PAN'nin ayırıcı tanısının vurgulanması amacıyla sunulmuştur. AbstractCutaneus polyarteritis nodosa is a variant of polyarteritis nodosa (PAN), without visceral involvement and with a more favourable prognosis. The presence of nodules, located in the lower legs are the most frequent cutaneous lesion. The etiology is unknown. Although cutaneous PAN carries a good prognosis, it can show development of systemic disease and relapses after follow-up. In this report, the case of a man with erythematous, painful nodules on his lower leg, who was misdiagnosed as cellulitis is described. The patient had been treated with many systemic antibiotics before coming to us. Although he was treated with systemic corticosteroids, after the third month of treatment, lesions appeared again. In this report, we aimed to emphasize the differential diagnosis of cutaneous PAN because of the recurrence of the disease. (Turk J Dermatol 2010; 4: 97-100)

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Relapsing cutaneous polyarteritis nodosa associated with streptococcal infections

Cited by 39 publications

References 20 publications

Cutaneous Polyarteritis Nodosa Presented with Digital Gangrene: A Case Report

Cutaneous Polyarteritis Nodosa Presented with Digital Gangrene: A Case Report

Revascularization by percutaneous transluminal angioplasty improved abruptly deteriorated ischaemic symptoms in cutaneous polyarteritis nodosa

Cutaneous Polyarteritis Nodosa

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